Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282036701> ?p ?o ?g. }
- W4282036701 endingPage "661" @default.
- W4282036701 startingPage "644" @default.
- W4282036701 abstract "Ophthalmic neurodegenerative diseases encompass a wide array of molecular pathologies unified by calpain dysregulation. Calpains are calcium-dependent proteases that perpetuate cellular death and inflammation when hyperactivated. Calpain inhibition trials in other organs have faced pharmacological challenges, but the eye offers many advantages for the development and testing of targeted molecular therapeutics, including small molecules, peptides, engineered proteins, drug implants, and gene-based therapies. This review highlights structural mechanisms underlying calpain activation, distinct cellular expression patterns, and in vivo models that link calpain hyperactivity to human retinal and developmental disease. Optimizing therapeutic approaches for calpain-mediated eye diseases can help accelerate clinically feasible strategies for treating calpain dysregulation in other diseased tissues." @default.
- W4282036701 created "2022-06-13" @default.
- W4282036701 creator A5003705103 @default.
- W4282036701 creator A5008395344 @default.
- W4282036701 creator A5008872960 @default.
- W4282036701 creator A5012657407 @default.
- W4282036701 creator A5031270506 @default.
- W4282036701 creator A5042402986 @default.
- W4282036701 creator A5053933172 @default.
- W4282036701 creator A5077563153 @default.
- W4282036701 date "2022-08-01" @default.
- W4282036701 modified "2023-10-16" @default.
- W4282036701 title "Calpains as mechanistic drivers and therapeutic targets for ocular disease" @default.
- W4282036701 cites W1461949916 @default.
- W4282036701 cites W1484399489 @default.
- W4282036701 cites W1518056982 @default.
- W4282036701 cites W1580653784 @default.
- W4282036701 cites W1694830366 @default.
- W4282036701 cites W1797659822 @default.
- W4282036701 cites W1896100809 @default.
- W4282036701 cites W1965185652 @default.
- W4282036701 cites W1965566484 @default.
- W4282036701 cites W1966407054 @default.
- W4282036701 cites W1972855577 @default.
- W4282036701 cites W1974513867 @default.
- W4282036701 cites W1975299720 @default.
- W4282036701 cites W1976818148 @default.
- W4282036701 cites W1980360074 @default.
- W4282036701 cites W1988274581 @default.
- W4282036701 cites W1990523450 @default.
- W4282036701 cites W1993009807 @default.
- W4282036701 cites W1993253390 @default.
- W4282036701 cites W1997151018 @default.
- W4282036701 cites W1999729097 @default.
- W4282036701 cites W2000325866 @default.
- W4282036701 cites W2005626802 @default.
- W4282036701 cites W2008495749 @default.
- W4282036701 cites W2010627829 @default.
- W4282036701 cites W2011087950 @default.
- W4282036701 cites W2013221728 @default.
- W4282036701 cites W2014769314 @default.
- W4282036701 cites W2015130230 @default.
- W4282036701 cites W2018848701 @default.
- W4282036701 cites W2026929555 @default.
- W4282036701 cites W2027955542 @default.
- W4282036701 cites W2029207164 @default.
- W4282036701 cites W2029955024 @default.
- W4282036701 cites W2030666693 @default.
- W4282036701 cites W2032686544 @default.
- W4282036701 cites W2033783426 @default.
- W4282036701 cites W2038767061 @default.
- W4282036701 cites W2039385604 @default.
- W4282036701 cites W2040698692 @default.
- W4282036701 cites W2044487484 @default.
- W4282036701 cites W2046370723 @default.
- W4282036701 cites W2047716158 @default.
- W4282036701 cites W2048788638 @default.
- W4282036701 cites W2049178118 @default.
- W4282036701 cites W2049265939 @default.
- W4282036701 cites W2051025707 @default.
- W4282036701 cites W2055231692 @default.
- W4282036701 cites W2057266151 @default.
- W4282036701 cites W2057708757 @default.
- W4282036701 cites W2061331516 @default.
- W4282036701 cites W2063214948 @default.
- W4282036701 cites W2069661739 @default.
- W4282036701 cites W2071606495 @default.
- W4282036701 cites W2074317235 @default.
- W4282036701 cites W2076198218 @default.
- W4282036701 cites W2076748222 @default.
- W4282036701 cites W2078616123 @default.
- W4282036701 cites W2084491272 @default.
- W4282036701 cites W2089625101 @default.
- W4282036701 cites W2092398508 @default.
- W4282036701 cites W2094933016 @default.
- W4282036701 cites W2102350508 @default.
- W4282036701 cites W2105336210 @default.
- W4282036701 cites W2111540139 @default.
- W4282036701 cites W2126497498 @default.
- W4282036701 cites W2127812965 @default.
- W4282036701 cites W2129020329 @default.
- W4282036701 cites W2133893126 @default.
- W4282036701 cites W2134158036 @default.
- W4282036701 cites W2136920201 @default.
- W4282036701 cites W2138480916 @default.
- W4282036701 cites W2141269860 @default.
- W4282036701 cites W2141814195 @default.
- W4282036701 cites W2142520482 @default.
- W4282036701 cites W2142603050 @default.
- W4282036701 cites W2143512531 @default.
- W4282036701 cites W2144900838 @default.
- W4282036701 cites W2150519492 @default.
- W4282036701 cites W2151115143 @default.
- W4282036701 cites W2154331071 @default.
- W4282036701 cites W2156292021 @default.
- W4282036701 cites W2161381121 @default.
- W4282036701 cites W2164571708 @default.
- W4282036701 cites W2169436026 @default.