Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282040256> ?p ?o ?g. }
- W4282040256 abstract "Ribitol phosphate modifications to the core M3 O-mannosyl glycan are important for the functional maturation of α-dystroglycan. Three sequentially extended partial structures of the core M3 O-mannosyl glycan including a tandem ribitol phosphate were regio- and stereo-selectively synthesized: Rbo5P-3GalNAcβ, Rbo5P-1Rbo5P-3GalNAcβ, and Xylβ1-4Rbo5P-1Rbo5P-3GalNAcβ (Rbo5P, d-ribitol-5-phosphate; GalNAc, N-acetyl-d-galactosamine; Xyl, d-xylose). Rbo5P-3GalNAcβ with p-nitrophenyl at the aglycon part served as a substrate for ribitol phosphate transferase (FKRP, fukutin-related protein), and its product was glycosylated by the actions of a series of glycosyltransferases, namely, ribitol xylosyltransferase 1 (RXYLT1), β1,4-glucuronyltransferase 1 (B4GAT1), and like-acetyl-glucosaminyltransferase (LARGE). Rbo5P-3GalNAcβ equipped with an alkyne-type aglycon was also active for FKRP. The molecular information obtained on FKRP suggests that Rbo5P-3GalNAcβ derivatives are the minimal units required as the acceptor glycan for Rbo5P transfer and may serve as a precursor for the elongation of the core M3 O-mannosyl glycan." @default.
- W4282040256 created "2022-06-13" @default.
- W4282040256 creator A5001724582 @default.
- W4282040256 creator A5011203970 @default.
- W4282040256 creator A5012542791 @default.
- W4282040256 creator A5023016790 @default.
- W4282040256 creator A5025593969 @default.
- W4282040256 creator A5034316497 @default.
- W4282040256 creator A5034709025 @default.
- W4282040256 creator A5043126305 @default.
- W4282040256 creator A5044498036 @default.
- W4282040256 creator A5052716791 @default.
- W4282040256 creator A5059157846 @default.
- W4282040256 creator A5062685178 @default.
- W4282040256 date "2022-06-06" @default.
- W4282040256 modified "2023-10-18" @default.
- W4282040256 title "Chemical and Chemo-Enzymatic Syntheses of Glycans Containing Ribitol Phosphate Scaffolding of Matriglycan" @default.
- W4282040256 cites W1528429662 @default.
- W4282040256 cites W1968643212 @default.
- W4282040256 cites W1972695095 @default.
- W4282040256 cites W2005319779 @default.
- W4282040256 cites W2029657985 @default.
- W4282040256 cites W2035526680 @default.
- W4282040256 cites W2044546343 @default.
- W4282040256 cites W2047850625 @default.
- W4282040256 cites W2061078665 @default.
- W4282040256 cites W2088740181 @default.
- W4282040256 cites W2115929911 @default.
- W4282040256 cites W2125981696 @default.
- W4282040256 cites W2132521116 @default.
- W4282040256 cites W2134377460 @default.
- W4282040256 cites W2167005352 @default.
- W4282040256 cites W2279197238 @default.
- W4282040256 cites W2469583314 @default.
- W4282040256 cites W2504491446 @default.
- W4282040256 cites W2530711020 @default.
- W4282040256 cites W2593808123 @default.
- W4282040256 cites W2736256022 @default.
- W4282040256 cites W2766321377 @default.
- W4282040256 cites W2908133755 @default.
- W4282040256 cites W2910768884 @default.
- W4282040256 cites W2999553950 @default.
- W4282040256 cites W3087358858 @default.
- W4282040256 doi "https://doi.org/10.1021/acschembio.2c00181" @default.
- W4282040256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35670527" @default.
- W4282040256 hasPublicationYear "2022" @default.
- W4282040256 type Work @default.
- W4282040256 citedByCount "0" @default.
- W4282040256 crossrefType "journal-article" @default.
- W4282040256 hasAuthorship W4282040256A5001724582 @default.
- W4282040256 hasAuthorship W4282040256A5011203970 @default.
- W4282040256 hasAuthorship W4282040256A5012542791 @default.
- W4282040256 hasAuthorship W4282040256A5023016790 @default.
- W4282040256 hasAuthorship W4282040256A5025593969 @default.
- W4282040256 hasAuthorship W4282040256A5034316497 @default.
- W4282040256 hasAuthorship W4282040256A5034709025 @default.
- W4282040256 hasAuthorship W4282040256A5043126305 @default.
- W4282040256 hasAuthorship W4282040256A5044498036 @default.
- W4282040256 hasAuthorship W4282040256A5052716791 @default.
- W4282040256 hasAuthorship W4282040256A5059157846 @default.
- W4282040256 hasAuthorship W4282040256A5062685178 @default.
- W4282040256 hasConcept C100817775 @default.
- W4282040256 hasConcept C108625454 @default.
- W4282040256 hasConcept C161019410 @default.
- W4282040256 hasConcept C181199279 @default.
- W4282040256 hasConcept C185592680 @default.
- W4282040256 hasConcept C206212055 @default.
- W4282040256 hasConcept C2776376580 @default.
- W4282040256 hasConcept C2780301084 @default.
- W4282040256 hasConcept C55493867 @default.
- W4282040256 hasConcept C71240020 @default.
- W4282040256 hasConcept C79156339 @default.
- W4282040256 hasConceptScore W4282040256C100817775 @default.
- W4282040256 hasConceptScore W4282040256C108625454 @default.
- W4282040256 hasConceptScore W4282040256C161019410 @default.
- W4282040256 hasConceptScore W4282040256C181199279 @default.
- W4282040256 hasConceptScore W4282040256C185592680 @default.
- W4282040256 hasConceptScore W4282040256C206212055 @default.
- W4282040256 hasConceptScore W4282040256C2776376580 @default.
- W4282040256 hasConceptScore W4282040256C2780301084 @default.
- W4282040256 hasConceptScore W4282040256C55493867 @default.
- W4282040256 hasConceptScore W4282040256C71240020 @default.
- W4282040256 hasConceptScore W4282040256C79156339 @default.
- W4282040256 hasFunder F4320334764 @default.
- W4282040256 hasLocation W42820402561 @default.
- W4282040256 hasLocation W42820402562 @default.
- W4282040256 hasOpenAccess W4282040256 @default.
- W4282040256 hasPrimaryLocation W42820402561 @default.
- W4282040256 hasRelatedWork W1963596436 @default.
- W4282040256 hasRelatedWork W2115402909 @default.
- W4282040256 hasRelatedWork W2141939877 @default.
- W4282040256 hasRelatedWork W2332522024 @default.
- W4282040256 hasRelatedWork W2410730792 @default.
- W4282040256 hasRelatedWork W2591459560 @default.
- W4282040256 hasRelatedWork W2950327806 @default.
- W4282040256 hasRelatedWork W3015981762 @default.
- W4282040256 hasRelatedWork W4224243767 @default.
- W4282040256 hasRelatedWork W4282040256 @default.
- W4282040256 isParatext "false" @default.
- W4282040256 isRetracted "false" @default.