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• W4282048531 startingPage "140" @default.
• W4282048531 abstract "We investigate therapeutic effects of monotherapy of oncolytic viruses, of adopted cell transfer, as well as the two combined therapies over a short time treatment period by applying optimal control techniques. The goal is to minimize the number of susceptible tumor cells and the costs associated with the therapy over the treatment period. We verify that there exists an optimal control pair and derive the necessary conditions. The optimality system is solved numerically to provide optimal protocols under different scenarios with respect to initial tumor sizes and parameter values. Although the two types of therapy do not work synergistically when the viral killing rate by immune cells is large, a small anti-viral killing can improve therapy success of either monotherapy of oncolytic viruses or combined therapy of oncolytic viruses and adopted T cell transfer. This finding can be accomplished either by manipulating certain genes of viruses via genetic engineering or by chemical modification of viral coat proteins to avoid detection by the immune cells." @default.
• W4282048531 created "2022-06-13" @default.
• W4282048531 creator A5050922328 @default.
• W4282048531 creator A5062390089 @default.
• W4282048531 date "2022-06-07" @default.
• W4282048531 modified "2023-10-05" @default.
• W4282048531 title "Optimal Immunotherapy of Oncolytic Viruses and Adopted Cell Transfer in Cancer Treatment" @default.
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• W4282048531 doi "https://doi.org/10.37394/23208.2022.19.15" @default.
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