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• W4282053600 abstract "Autophagy is a homeostatic process responsible for the self-digestion of intracellular components and antimicrobial defense by inducing the degradation of pathogens into autophagolysosomes. Recent findings suggest an involvement of this process in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, the role of autophagy in the immunological mechanisms of coronavirus disease 2019 (COVID-19) pathogenesis remains largely unexplored. This study reveals the presence of autophagy defects in peripheral immune cells from COVID-19 patients. The impairment of the autophagy process resulted in a higher percentage of lymphocytes undergoing apoptosis in COVID-19 patients. Moreover, the inverse correlation between autophagy markers levels and peripheral lymphocyte counts in COVID-19 patients confirms how a defect in autophagy might contribute to lymphopenia, causing a reduction in the activation of viral defense. These results provided intriguing data that could help in understanding the cellular underlying mechanisms in COVID-19 infection, especially in severe forms." @default.
• W4282053600 created "2022-06-13" @default.
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• W4282053600 date "2022-05-30" @default.
• W4282053600 modified "2023-09-27" @default.
• W4282053600 title "Autophagy Hijacking in PBMC From COVID-19 Patients Results in Lymphopenia" @default.
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• W4282053600 doi "https://doi.org/10.3389/fimmu.2022.903498" @default.
• W4282053600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35711451" @default.
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