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• W4282542467 abstract "Ratiometric biosensor is among the promising strategies for the advanced analysis; its applicability in multiple scenarios, however, is seriously limited for the fixed analytical feature. Here, we reported ratiometric electrochemical biosensors with programmable analytical feature by alternating the binding site of ferrocene (Fc) to DNA duplex for the detection of aflatoxin B1 (AFB1). DNA duplex was synthesized with AFB1 aptamer and its complementary DNA (cDNA) with Fc molecular tagged on aptamer or cDNA. For analysis, aptamer-AFB1 complex stripped from the electrode, and free cDNA triggered hybridization chain reaction to produce double-stranded DNA for methylene blue (MB) absorption. In this way, redox currents of Fc (IFc) and absorbed MB (IMB) at the electrode were collected to produce the ratiometric signal of IMB/IFc as a yardstick for AFB1. When Fc was tagged on aptamer, IFc decreased with higher concentration of AFB1 (cAFB1), the resultant biosensor allowed detection with an On/Off (IMB/IFc) mode; when Fc was tagged on cDNA, IFc kept constant as cAFB1 varying, offering an On/Constant (IMB/IFc) mode for the detection. Consequently, biosensor with On/Off mode showed a linear range of 0.1−100 pg mL-1 with a limit of detection (LOD) of 0.0650 pg mL-1, while biosensor with On/Constant mode offered a wider linear rang of 1−10000 pg mL-1 but a relatively poor LOD of 0.330 pg mL-1. Our work revealed the vital importance of binding site of probes to DNA, and this principle can endow ratiometric biosensor with programmable analytical feature (e.g., linear range, LOD), allowing detections in various scenarios. This article is protected by copyright. All rights reserved." @default.
• W4282542467 created "2022-06-14" @default.
• W4282542467 creator A5033112242 @default.
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• W4282542467 date "2022-07-14" @default.
• W4282542467 modified "2023-09-26" @default.
• W4282542467 title "Programmable Analytical Feature of Ratiometric Electrochemical Biosensor by Alternating the Binding Site of Ferrocene to <scp>DNA</scp> Duplex for the Detection of Aflatoxin <scp>B1</scp> ^†" @default.
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• W4282542467 doi "https://doi.org/10.1002/cjoc.202200155" @default.
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