Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282549516> ?p ?o ?g. }
- W4282549516 endingPage "803" @default.
- W4282549516 startingPage "792" @default.
- W4282549516 abstract "Congenital heart diseases often involve maldevelopment of the evolutionarily recent right heart chamber. To gain insight into right heart structure and function, we fine-tuned deep learning models to recognize the right atrium, right ventricle and pulmonary artery, measuring right heart structures in 40,000 individuals from the UK Biobank with magnetic resonance imaging. Genome-wide association studies identified 130 distinct loci associated with at least one right heart measurement, of which 72 were not associated with left heart structures. Loci were found near genes previously linked with congenital heart disease, including NKX2-5, TBX5/TBX3, WNT9B and GATA4. A genome-wide polygenic predictor of right ventricular ejection fraction was associated with incident dilated cardiomyopathy (hazard ratio, 1.33 per standard deviation; P = 7.1 × 10-13) and remained significant after accounting for a left ventricular polygenic score. Harnessing deep learning to perform large-scale cardiac phenotyping, our results yield insights into the genetic determinants of right heart structure and function." @default.
- W4282549516 created "2022-06-14" @default.
- W4282549516 creator A5000262222 @default.
- W4282549516 creator A5004356613 @default.
- W4282549516 creator A5005068404 @default.
- W4282549516 creator A5005297730 @default.
- W4282549516 creator A5008444707 @default.
- W4282549516 creator A5009692222 @default.
- W4282549516 creator A5010690225 @default.
- W4282549516 creator A5011341854 @default.
- W4282549516 creator A5011453870 @default.
- W4282549516 creator A5014525847 @default.
- W4282549516 creator A5018161559 @default.
- W4282549516 creator A5018714380 @default.
- W4282549516 creator A5019972830 @default.
- W4282549516 creator A5024590816 @default.
- W4282549516 creator A5024641774 @default.
- W4282549516 creator A5026281541 @default.
- W4282549516 creator A5030590605 @default.
- W4282549516 creator A5030828714 @default.
- W4282549516 creator A5032156090 @default.
- W4282549516 creator A5033755499 @default.
- W4282549516 creator A5035379848 @default.
- W4282549516 creator A5037242040 @default.
- W4282549516 creator A5038862421 @default.
- W4282549516 creator A5041028758 @default.
- W4282549516 creator A5042984133 @default.
- W4282549516 creator A5043724877 @default.
- W4282549516 creator A5047884631 @default.
- W4282549516 creator A5048066616 @default.
- W4282549516 creator A5052881041 @default.
- W4282549516 creator A5054621091 @default.
- W4282549516 creator A5054879244 @default.
- W4282549516 creator A5056051352 @default.
- W4282549516 creator A5057781163 @default.
- W4282549516 creator A5064309113 @default.
- W4282549516 creator A5066782777 @default.
- W4282549516 creator A5067029985 @default.
- W4282549516 creator A5069822855 @default.
- W4282549516 creator A5070430680 @default.
- W4282549516 creator A5071770530 @default.
- W4282549516 creator A5072404313 @default.
- W4282549516 creator A5073041790 @default.
- W4282549516 creator A5076968285 @default.
- W4282549516 creator A5078716241 @default.
- W4282549516 creator A5079980365 @default.
- W4282549516 creator A5080846170 @default.
- W4282549516 creator A5080980467 @default.
- W4282549516 creator A5084721457 @default.
- W4282549516 creator A5086799592 @default.
- W4282549516 creator A5091367654 @default.
- W4282549516 creator A5091782480 @default.
- W4282549516 date "2022-06-01" @default.
- W4282549516 modified "2023-10-17" @default.
- W4282549516 title "Genetic analysis of right heart structure and function in 40,000 people" @default.
- W4282549516 cites W1488372279 @default.
- W4282549516 cites W1570622790 @default.
- W4282549516 cites W1844405070 @default.
- W4282549516 cites W1965271063 @default.
- W4282549516 cites W1966775465 @default.
- W4282549516 cites W1970771731 @default.
- W4282549516 cites W1980141913 @default.
- W4282549516 cites W1987869189 @default.
- W4282549516 cites W1989883444 @default.
- W4282549516 cites W1994728175 @default.
- W4282549516 cites W1997415972 @default.
- W4282549516 cites W2000779896 @default.
- W4282549516 cites W2003438163 @default.
- W4282549516 cites W2010457001 @default.
- W4282549516 cites W2014795299 @default.
- W4282549516 cites W2018838463 @default.
- W4282549516 cites W2025218263 @default.
- W4282549516 cites W2028261742 @default.
- W4282549516 cites W2030160331 @default.
- W4282549516 cites W2031211185 @default.
- W4282549516 cites W2031635700 @default.
- W4282549516 cites W2063172243 @default.
- W4282549516 cites W2068320219 @default.
- W4282549516 cites W2069040148 @default.
- W4282549516 cites W2070175168 @default.
- W4282549516 cites W2075011348 @default.
- W4282549516 cites W2081872599 @default.
- W4282549516 cites W2082704080 @default.
- W4282549516 cites W2083347345 @default.
- W4282549516 cites W2085121027 @default.
- W4282549516 cites W2088204183 @default.
- W4282549516 cites W2098597314 @default.
- W4282549516 cites W2099085143 @default.
- W4282549516 cites W2102450596 @default.
- W4282549516 cites W2102927207 @default.
- W4282549516 cites W2104382557 @default.
- W4282549516 cites W2104549677 @default.
- W4282549516 cites W2108598243 @default.
- W4282549516 cites W2113897048 @default.
- W4282549516 cites W2116948892 @default.
- W4282549516 cites W2128034717 @default.
- W4282549516 cites W2130410032 @default.
- W4282549516 cites W2131810639 @default.