Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282552020> ?p ?o ?g. }
- W4282552020 abstract "Abstract Multi‐component carbonylation of olefins, a reaction that installs both a carbon–carbon(heteroatom) bond and a carbonyl group across the double bond, is an attractive strategy for alkene functionalization. Herein, we developed a novel nickel‐catalyzed four‐component carbonylation of olefins with ethers under low CO gas pressure. Using alcohols and amines as the reaction partner, diverse γ ‐oxy‐substituted esters and amides were produced in good yields with excellent functional group tolerance. Notably, Naftidrofuryl, a medicine for the treatment of cerebrovascular disease (CVD), can be synthesized by this process straightforwardly." @default.
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- W4282552020 date "2022-07-05" @default.
- W4282552020 modified "2023-10-18" @default.
- W4282552020 title "Nickel‐Catalyzed Four‐Component Carbonylation of Ethers and Olefins: Direct Access to <i>γ</i>‐Oxy Esters and Amides" @default.
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- W4282552020 doi "https://doi.org/10.1002/anie.202207970" @default.
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