FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282582692> ?p ?o ?g. }

• W4282582692 abstract "Early-life stress (ELS) leads to increased vulnerability for mental and metabolic disorders. We have previously shown that a low dietary ω-6/ω-3 polyunsaturated fatty acid (PUFA) ratio protects against ELS-induced cognitive impairments. Due to the importance of the gut microbiota as a determinant of long-term health, we here study the impact of ELS and dietary PUFAs on the gut microbiota and how this relates to the previously described cognitive, metabolic, and fatty acid profiles. Male mice were exposed to ELS via the limited bedding and nesting paradigm (postnatal day (P)2 to P9 and to an early diet (P2 to P42) with an either high (15) or low (1) ω-6 linoleic acid to ω-3 alpha-linolenic acid ratio. 16S rRNA was sequenced and analyzed from fecal samples at P21, P42, and P180. Age impacted α- and β-diversity. ELS and diet together predicted variance in microbiota composition and affected the relative abundance of bacterial groups at several taxonomic levels in the short and long term. For example, age increased the abundance of the phyla Bacteroidetes, while it decreased Actinobacteria and Verrucomicrobia; ELS reduced the genera RC9 gut group and Rikenella, and the low ω-6/ω-3 diet reduced the abundance of the Firmicutes Erysipelotrichia. At P42, species abundance correlated with body fat mass and circulating leptin (e.g., Bacteroidetes and Proteobacteria taxa) and fatty acid profiles (e.g., Firmicutes taxa). This study gives novel insights into the impact of age, ELS, and dietary PUFAs on microbiota composition, providing potential targets for noninvasive (nutritional) modulation of ELS-induced deficits. IMPORTANCE Early-life stress (ELS) leads to increased vulnerability to develop mental and metabolic disorders; however, the biological mechanisms leading to such programming are not fully clear. Increased attention has been given to the importance of the gut microbiota as a determinant of long-term health and as a potential target for noninvasive nutritional strategies to protect against the negative impact of ELS. Here, we give novel insights into the complex interaction between ELS, early dietary ω-3 availability, and the gut microbiota across ages and provide new potential targets for (nutritional) modulation of the long-term effects of the early-life environment via the microbiota." @default.
• W4282582692 created "2022-06-14" @default.
• W4282582692 creator A5017791828 @default.
• W4282582692 creator A5035542643 @default.
• W4282582692 creator A5043459829 @default.
• W4282582692 creator A5066849637 @default.
• W4282582692 creator A5067535218 @default.
• W4282582692 creator A5076907548 @default.
• W4282582692 creator A5080587024 @default.
• W4282582692 creator A5085392818 @default.
• W4282582692 date "2022-06-28" @default.
• W4282582692 modified "2023-09-26" @default.
• W4282582692 title "The Role of the Gut Microbiota in the Effects of Early-Life Stress and Dietary Fatty Acids on Later-Life Central and Metabolic Outcomes in Mice" @default.
• W4282582692 cites W1515023627 @default.
• W4282582692 cites W1620047260 @default.
• W4282582692 cites W1831301545 @default.
• W4282582692 cites W1921871707 @default.
• W4282582692 cites W1964244234 @default.
• W4282582692 cites W1968105193 @default.
• W4282582692 cites W1968721722 @default.
• W4282582692 cites W1977804070 @default.
• W4282582692 cites W1979080859 @default.
• W4282582692 cites W1987636018 @default.
• W4282582692 cites W1988125482 @default.
• W4282582692 cites W1995250682 @default.
• W4282582692 cites W1995417833 @default.
• W4282582692 cites W1997579399 @default.
• W4282582692 cites W1999149427 @default.
• W4282582692 cites W2010055058 @default.
• W4282582692 cites W2011914193 @default.
• W4282582692 cites W2031611770 @default.
• W4282582692 cites W2035555128 @default.
• W4282582692 cites W2038133823 @default.
• W4282582692 cites W2051615340 @default.
• W4282582692 cites W2052028140 @default.
• W4282582692 cites W2053477452 @default.
• W4282582692 cites W2055544117 @default.
• W4282582692 cites W2058029859 @default.
• W4282582692 cites W2063527523 @default.
• W4282582692 cites W2072970694 @default.
• W4282582692 cites W2087292184 @default.
• W4282582692 cites W2091922579 @default.
• W4282582692 cites W2095014164 @default.
• W4282582692 cites W2097478615 @default.
• W4282582692 cites W2098503261 @default.
• W4282582692 cites W2098762803 @default.
• W4282582692 cites W2099664199 @default.
• W4282582692 cites W2101120467 @default.
• W4282582692 cites W2104037158 @default.
• W4282582692 cites W2105381419 @default.
• W4282582692 cites W2105841516 @default.
• W4282582692 cites W2107155323 @default.
• W4282582692 cites W2114214305 @default.
• W4282582692 cites W2115701239 @default.
• W4282582692 cites W2116846792 @default.
• W4282582692 cites W2117994717 @default.
• W4282582692 cites W2124351063 @default.
• W4282582692 cites W2128623683 @default.
• W4282582692 cites W2130721477 @default.
• W4282582692 cites W2142305968 @default.
• W4282582692 cites W2148103005 @default.
• W4282582692 cites W2151158825 @default.
• W4282582692 cites W2152995125 @default.
• W4282582692 cites W2155066423 @default.
• W4282582692 cites W2158630697 @default.
• W4282582692 cites W2162088497 @default.
• W4282582692 cites W2166171121 @default.
• W4282582692 cites W2166562121 @default.
• W4282582692 cites W2167062509 @default.
• W4282582692 cites W2231115651 @default.
• W4282582692 cites W2290190425 @default.
• W4282582692 cites W2336330109 @default.
• W4282582692 cites W2337509055 @default.
• W4282582692 cites W2347021123 @default.
• W4282582692 cites W2462715376 @default.
• W4282582692 cites W2470154003 @default.
• W4282582692 cites W2470512478 @default.
• W4282582692 cites W2517796697 @default.
• W4282582692 cites W2537252495 @default.
• W4282582692 cites W2550084345 @default.
• W4282582692 cites W2556627287 @default.
• W4282582692 cites W2559826890 @default.
• W4282582692 cites W2562701561 @default.
• W4282582692 cites W2585159410 @default.
• W4282582692 cites W2592627283 @default.
• W4282582692 cites W2624151437 @default.
• W4282582692 cites W2625629260 @default.
• W4282582692 cites W2734661842 @default.
• W4282582692 cites W2749743535 @default.
• W4282582692 cites W2751139765 @default.
• W4282582692 cites W2755288394 @default.
• W4282582692 cites W2758490346 @default.
• W4282582692 cites W2768044583 @default.
• W4282582692 cites W2772974937 @default.
• W4282582692 cites W2782568522 @default.
• W4282582692 cites W2789258876 @default.
• W4282582692 cites W2790762997 @default.
• W4282582692 cites W2802890706 @default.
• W4282582692 cites W2810733185 @default.
• W4282582692 cites W2863269164 @default.

• next