Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282586887> ?p ?o ?g. }
- W4282586887 endingPage "114679" @default.
- W4282586887 startingPage "114679" @default.
- W4282586887 abstract "Deciphering the genetic relationships between autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) may uncover underlining shared pathophysiology as well as inform treatment. The summary results of genome-wide association studies on ADHD, ASD, and extraversion were utilized for the analyzes. Genetic correlations between ADHD, ASD, and extraversion were tested using linkage disequilibrium score regression. Causal relationships between ADHD, ASD, and extraversion were investigated using Mendelian randomization (MR) analysis. Novel pleiotropic genomic loci shared by ADHD and ASD were identified using a cross-trait meta-analysis. Extraversion was positively correlated with ADHD (rg = 0.205) and negatively correlated with ASD (rg = −0.193). The MR analysis showed that ADHD confers a causal effect on ASD (OR: 1.35, 95% confidence interval (CI):1.20–1.52) and vice versa (1.46, 1.38–1.55). Extraversion exerts a causal effect on ADHD only (1.19, 1.05–1.33). The cross-trait meta-analysis identified three novel pleiotropic genomic loci for ADHD and ASD, involving two pleiotropic genes, LINC00461 and KIZ. Our study provides new insights into the shared genetics of ADHD and ASD and their connections with extraversion." @default.
- W4282586887 created "2022-06-14" @default.
- W4282586887 creator A5004917901 @default.
- W4282586887 creator A5019716362 @default.
- W4282586887 creator A5020544737 @default.
- W4282586887 creator A5036232375 @default.
- W4282586887 creator A5039896971 @default.
- W4282586887 creator A5045591391 @default.
- W4282586887 creator A5053111614 @default.
- W4282586887 creator A5065313978 @default.
- W4282586887 creator A5065986636 @default.
- W4282586887 creator A5069826909 @default.
- W4282586887 creator A5079946688 @default.
- W4282586887 creator A5063347038 @default.
- W4282586887 date "2022-08-01" @default.
- W4282586887 modified "2023-10-09" @default.
- W4282586887 title "Shared genetics between autism spectrum disorder and attention-deficit/hyperactivity disorder and their association with extraversion" @default.
- W4282586887 cites W1855058198 @default.
- W4282586887 cites W1949064740 @default.
- W4282586887 cites W1964395620 @default.
- W4282586887 cites W1997958982 @default.
- W4282586887 cites W2005387753 @default.
- W4282586887 cites W2018684776 @default.
- W4282586887 cites W2038531472 @default.
- W4282586887 cites W2061188104 @default.
- W4282586887 cites W2079257314 @default.
- W4282586887 cites W2104549677 @default.
- W4282586887 cites W2139360040 @default.
- W4282586887 cites W2139852368 @default.
- W4282586887 cites W2148175113 @default.
- W4282586887 cites W2153860431 @default.
- W4282586887 cites W2195783463 @default.
- W4282586887 cites W2340656051 @default.
- W4282586887 cites W2345662338 @default.
- W4282586887 cites W2462634178 @default.
- W4282586887 cites W2534955677 @default.
- W4282586887 cites W2605164917 @default.
- W4282586887 cites W2626162123 @default.
- W4282586887 cites W2754290562 @default.
- W4282586887 cites W2770092353 @default.
- W4282586887 cites W2802637558 @default.
- W4282586887 cites W2802815532 @default.
- W4282586887 cites W2802987572 @default.
- W4282586887 cites W2808011097 @default.
- W4282586887 cites W2891530254 @default.
- W4282586887 cites W2914482125 @default.
- W4282586887 cites W2949543964 @default.
- W4282586887 cites W2962392267 @default.
- W4282586887 cites W2993353518 @default.
- W4282586887 cites W2994566096 @default.
- W4282586887 cites W3037717637 @default.
- W4282586887 cites W3038944827 @default.
- W4282586887 cites W3042400174 @default.
- W4282586887 cites W3116613908 @default.
- W4282586887 cites W3118854417 @default.
- W4282586887 cites W3155779431 @default.
- W4282586887 cites W3161994384 @default.
- W4282586887 cites W3175888462 @default.
- W4282586887 cites W3184586053 @default.
- W4282586887 cites W3190522036 @default.
- W4282586887 cites W3196599268 @default.
- W4282586887 cites W3213824126 @default.
- W4282586887 cites W4206196226 @default.
- W4282586887 cites W4206405722 @default.
- W4282586887 cites W4210386368 @default.
- W4282586887 cites W4213387635 @default.
- W4282586887 cites W4226277149 @default.
- W4282586887 doi "https://doi.org/10.1016/j.psychres.2022.114679" @default.
- W4282586887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35717853" @default.
- W4282586887 hasPublicationYear "2022" @default.
- W4282586887 type Work @default.
- W4282586887 citedByCount "17" @default.
- W4282586887 countsByYear W42825868872022 @default.
- W4282586887 countsByYear W42825868872023 @default.
- W4282586887 crossrefType "journal-article" @default.
- W4282586887 hasAuthorship W4282586887A5004917901 @default.
- W4282586887 hasAuthorship W4282586887A5019716362 @default.
- W4282586887 hasAuthorship W4282586887A5020544737 @default.
- W4282586887 hasAuthorship W4282586887A5036232375 @default.
- W4282586887 hasAuthorship W4282586887A5039896971 @default.
- W4282586887 hasAuthorship W4282586887A5045591391 @default.
- W4282586887 hasAuthorship W4282586887A5053111614 @default.
- W4282586887 hasAuthorship W4282586887A5063347038 @default.
- W4282586887 hasAuthorship W4282586887A5065313978 @default.
- W4282586887 hasAuthorship W4282586887A5065986636 @default.
- W4282586887 hasAuthorship W4282586887A5069826909 @default.
- W4282586887 hasAuthorship W4282586887A5079946688 @default.
- W4282586887 hasConcept C104317684 @default.
- W4282586887 hasConcept C106208931 @default.
- W4282586887 hasConcept C127816348 @default.
- W4282586887 hasConcept C135763542 @default.
- W4282586887 hasConcept C138496976 @default.
- W4282586887 hasConcept C153209595 @default.
- W4282586887 hasConcept C15744967 @default.
- W4282586887 hasConcept C186413461 @default.
- W4282586887 hasConcept C187288502 @default.
- W4282586887 hasConcept C205778803 @default.
- W4282586887 hasConcept C2778538070 @default.