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- W4282590217 abstract "SecA, an ATPase known to posttranslationally translocate secretory proteins across the bacterial plasma membrane, also binds ribosomes, but the role of SecA's ribosome interaction has been unclear. Here, we used a combination of ribosome profiling methods to investigate the cotranslational actions of SecA. Our data reveal the widespread accumulation of large periplasmic loops of inner membrane proteins in the cytoplasm during their cotranslational translocation, which are specifically recognized and resolved by SecA in coordination with the proton motive force (PMF). Furthermore, SecA associates with 25% of secretory proteins with highly hydrophobic signal sequences at an early stage of translation and mediates their cotranslational transport. In contrast, the chaperone trigger factor (TF) delays SecA engagement on secretory proteins with weakly hydrophobic signal sequences, thus enforcing a posttranslational mode of their translocation. Our results elucidate the principles of SecA-driven cotranslational protein translocation and reveal a hierarchical network of protein export pathways in bacteria." @default.
- W4282590217 created "2022-06-14" @default.
- W4282590217 creator A5000584662 @default.
- W4282590217 creator A5033632264 @default.
- W4282590217 creator A5067259889 @default.
- W4282590217 date "2022-06-13" @default.
- W4282590217 modified "2023-10-16" @default.
- W4282590217 title "Ribosome profiling reveals multiple roles of SecA in cotranslational protein export" @default.
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- W4282590217 doi "https://doi.org/10.1038/s41467-022-31061-5" @default.
- W4282590217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35697696" @default.
- W4282590217 hasPublicationYear "2022" @default.
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