Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282592954> ?p ?o ?g. }
- W4282592954 endingPage "655" @default.
- W4282592954 startingPage "646" @default.
- W4282592954 abstract "Hundreds of leucine-rich repeat receptor kinases (LRR-RKs) have evolved to control diverse processes of growth, development and immunity in plants, but the mechanisms that link LRR-RKs to distinct cellular responses are not understood. Here we show that two LRR-RKs, the brassinosteroid hormone receptor BRASSINOSTEROID INSENSITIVE 1 (BRI1) and the flagellin receptor FLAGELLIN SENSING 2 (FLS2), regulate downstream glycogen synthase kinase 3 (GSK3) and mitogen-activated protein (MAP) kinases, respectively, through phosphocoding of the BRI1-SUPPRESSOR1 (BSU1) phosphatase. BSU1 was previously identified as a component that inactivates GSK3s in the BRI1 pathway. We surprisingly found that the loss of the BSU1 family phosphatases activates effector-triggered immunity and impairs flagellin-triggered MAP kinase activation and immunity. The flagellin-activated BOTRYTIS-INDUCED KINASE 1 (BIK1) phosphorylates BSU1 at serine 251. Mutation of serine 251 reduces BSU1’s ability to mediate flagellin-induced MAP kinase activation and immunity, but not its abilities to suppress effector-triggered immunity and interact with GSK3, which is enhanced through the phosphorylation of BSU1 at serine 764 upon brassinosteroid signalling. These results demonstrate that BSU1 plays an essential role in immunity and transduces brassinosteroid–BRI1 and flagellin–FLS2 signals using different phosphorylation sites. Our study illustrates that phosphocoding in shared downstream components provides signalling specificities for diverse plant receptor kinases. How pathogen signals perceived by receptor kinases activate plant immunity is not fully understood. Here the authors show that phosphocoding of a shared phosphatase ensures signalling from growth and immune receptors to specific cellular responses." @default.
- W4282592954 created "2022-06-14" @default.
- W4282592954 creator A5000677749 @default.
- W4282592954 creator A5004445063 @default.
- W4282592954 creator A5007255120 @default.
- W4282592954 creator A5011176089 @default.
- W4282592954 creator A5015215703 @default.
- W4282592954 creator A5029449556 @default.
- W4282592954 creator A5030674465 @default.
- W4282592954 creator A5035975002 @default.
- W4282592954 creator A5048646837 @default.
- W4282592954 creator A5048774361 @default.
- W4282592954 creator A5053970026 @default.
- W4282592954 creator A5068865174 @default.
- W4282592954 creator A5084714769 @default.
- W4282592954 date "2022-06-13" @default.
- W4282592954 modified "2023-10-16" @default.
- W4282592954 title "Deconvoluting signals downstream of growth and immune receptor kinases by phosphocodes of the BSU1 family phosphatases" @default.
- W4282592954 cites W1964846007 @default.
- W4282592954 cites W1971615018 @default.
- W4282592954 cites W1978179863 @default.
- W4282592954 cites W1979369744 @default.
- W4282592954 cites W1994481770 @default.
- W4282592954 cites W1994602890 @default.
- W4282592954 cites W2000350495 @default.
- W4282592954 cites W2003589345 @default.
- W4282592954 cites W2007619416 @default.
- W4282592954 cites W2012009287 @default.
- W4282592954 cites W2043215109 @default.
- W4282592954 cites W2058255168 @default.
- W4282592954 cites W2059336476 @default.
- W4282592954 cites W2065462380 @default.
- W4282592954 cites W2082628255 @default.
- W4282592954 cites W2089833124 @default.
- W4282592954 cites W2090950329 @default.
- W4282592954 cites W2098106646 @default.
- W4282592954 cites W2106488895 @default.
- W4282592954 cites W2120746999 @default.
- W4282592954 cites W2123844599 @default.
- W4282592954 cites W2132801043 @default.
- W4282592954 cites W2135956678 @default.
- W4282592954 cites W2141091417 @default.
- W4282592954 cites W2141429272 @default.
- W4282592954 cites W2143406588 @default.
- W4282592954 cites W2143964569 @default.
- W4282592954 cites W2143983383 @default.
- W4282592954 cites W2147863419 @default.
- W4282592954 cites W2157519119 @default.
- W4282592954 cites W2163448850 @default.
- W4282592954 cites W2164945218 @default.
- W4282592954 cites W2208832531 @default.
- W4282592954 cites W2611604995 @default.
- W4282592954 cites W2806969111 @default.
- W4282592954 cites W2916704383 @default.
- W4282592954 cites W3092946627 @default.
- W4282592954 cites W3113293229 @default.
- W4282592954 cites W3135339687 @default.
- W4282592954 cites W3135815505 @default.
- W4282592954 cites W3159763520 @default.
- W4282592954 cites W3195620775 @default.
- W4282592954 cites W4200113921 @default.
- W4282592954 cites W45534775 @default.
- W4282592954 doi "https://doi.org/10.1038/s41477-022-01167-1" @default.
- W4282592954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35697730" @default.
- W4282592954 hasPublicationYear "2022" @default.
- W4282592954 type Work @default.
- W4282592954 citedByCount "8" @default.
- W4282592954 countsByYear W42825929542022 @default.
- W4282592954 countsByYear W42825929542023 @default.
- W4282592954 crossrefType "journal-article" @default.
- W4282592954 hasAuthorship W4282592954A5000677749 @default.
- W4282592954 hasAuthorship W4282592954A5004445063 @default.
- W4282592954 hasAuthorship W4282592954A5007255120 @default.
- W4282592954 hasAuthorship W4282592954A5011176089 @default.
- W4282592954 hasAuthorship W4282592954A5015215703 @default.
- W4282592954 hasAuthorship W4282592954A5029449556 @default.
- W4282592954 hasAuthorship W4282592954A5030674465 @default.
- W4282592954 hasAuthorship W4282592954A5035975002 @default.
- W4282592954 hasAuthorship W4282592954A5048646837 @default.
- W4282592954 hasAuthorship W4282592954A5048774361 @default.
- W4282592954 hasAuthorship W4282592954A5053970026 @default.
- W4282592954 hasAuthorship W4282592954A5068865174 @default.
- W4282592954 hasAuthorship W4282592954A5084714769 @default.
- W4282592954 hasBestOaLocation W42825929542 @default.
- W4282592954 hasConcept C104317684 @default.
- W4282592954 hasConcept C11960822 @default.
- W4282592954 hasConcept C132149769 @default.
- W4282592954 hasConcept C143065580 @default.
- W4282592954 hasConcept C170493617 @default.
- W4282592954 hasConcept C178666793 @default.
- W4282592954 hasConcept C184235292 @default.
- W4282592954 hasConcept C2778778573 @default.
- W4282592954 hasConcept C2779491563 @default.
- W4282592954 hasConcept C2910050888 @default.
- W4282592954 hasConcept C38117629 @default.
- W4282592954 hasConcept C51785407 @default.
- W4282592954 hasConcept C55493867 @default.
- W4282592954 hasConcept C62478195 @default.