Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282600216> ?p ?o ?g. }
- W4282600216 endingPage "3946" @default.
- W4282600216 startingPage "3937" @default.
- W4282600216 abstract "Currently, there are no approved medicines available for the treatment of hearing loss. However, research over the past two decades has contributed to a growing understanding of the pathological mechanisms in the cochlea that result in hearing difficulties. The concept that a loss of the synapses connecting inner hair cells with the auditory nerve (cochlear synaptopathy) contributes to hearing loss has gained considerable attention. Both animal and human post-mortem studies support the idea that these synapses (ribbon synapses) are highly vulnerable to noise, ototoxicity, and the aging process. Their degeneration has been suggested as an important factor in the speech-in-noise difficulties commonly experienced by those suffering with hearing loss. Neurotrophins such as brain derived neurotrophic factor (BDNF) have the potential to restore these synapses and provide improved hearing function. OTO-413 is a sustained exposure formulation of BDNF suitable for intratympanic administration that in preclinical models has shown the ability to restore ribbon synapses and provide functional hearing benefit. A phase 1/2 clinical trial with OTO-413 has provided initial proof-of-concept for improved speech-in-noise hearing performance in subjects with hearing loss. Key considerations for the design of this clinical study, including aspects of the speech-in-noise assessments, are discussed." @default.
- W4282600216 created "2022-06-14" @default.
- W4282600216 creator A5014284262 @default.
- W4282600216 creator A5027728332 @default.
- W4282600216 creator A5049259708 @default.
- W4282600216 creator A5056598194 @default.
- W4282600216 creator A5067359836 @default.
- W4282600216 creator A5075831579 @default.
- W4282600216 creator A5076918693 @default.
- W4282600216 date "2022-06-01" @default.
- W4282600216 modified "2023-10-14" @default.
- W4282600216 title "A neurotrophic approach to treating hearing loss: Translation from animal models to clinical proof-of-concept" @default.
- W4282600216 cites W1109970925 @default.
- W4282600216 cites W1423335706 @default.
- W4282600216 cites W1545898285 @default.
- W4282600216 cites W1613493818 @default.
- W4282600216 cites W1747609093 @default.
- W4282600216 cites W1847168837 @default.
- W4282600216 cites W1964357725 @default.
- W4282600216 cites W1969377882 @default.
- W4282600216 cites W1975675577 @default.
- W4282600216 cites W1975935202 @default.
- W4282600216 cites W1978721968 @default.
- W4282600216 cites W1987022414 @default.
- W4282600216 cites W1989932830 @default.
- W4282600216 cites W1992695138 @default.
- W4282600216 cites W1999633987 @default.
- W4282600216 cites W2005605997 @default.
- W4282600216 cites W2013917329 @default.
- W4282600216 cites W2016688531 @default.
- W4282600216 cites W2018938454 @default.
- W4282600216 cites W2029162013 @default.
- W4282600216 cites W2031579006 @default.
- W4282600216 cites W2034040572 @default.
- W4282600216 cites W2036966153 @default.
- W4282600216 cites W2040476517 @default.
- W4282600216 cites W2051513674 @default.
- W4282600216 cites W2051951610 @default.
- W4282600216 cites W2056829537 @default.
- W4282600216 cites W2057725339 @default.
- W4282600216 cites W2070248369 @default.
- W4282600216 cites W2096363656 @default.
- W4282600216 cites W2097498366 @default.
- W4282600216 cites W2103551437 @default.
- W4282600216 cites W2130323061 @default.
- W4282600216 cites W2146287280 @default.
- W4282600216 cites W2152933007 @default.
- W4282600216 cites W2154238392 @default.
- W4282600216 cites W2162804110 @default.
- W4282600216 cites W2169478622 @default.
- W4282600216 cites W2203895492 @default.
- W4282600216 cites W222028059 @default.
- W4282600216 cites W2293983617 @default.
- W4282600216 cites W2317830494 @default.
- W4282600216 cites W2327050732 @default.
- W4282600216 cites W2345177852 @default.
- W4282600216 cites W2412036897 @default.
- W4282600216 cites W2430694437 @default.
- W4282600216 cites W2510415332 @default.
- W4282600216 cites W2520285939 @default.
- W4282600216 cites W2520380456 @default.
- W4282600216 cites W2546970346 @default.
- W4282600216 cites W2567954113 @default.
- W4282600216 cites W2568449460 @default.
- W4282600216 cites W2621648999 @default.
- W4282600216 cites W2730398527 @default.
- W4282600216 cites W2745540351 @default.
- W4282600216 cites W2886113798 @default.
- W4282600216 cites W2886288118 @default.
- W4282600216 cites W2901376813 @default.
- W4282600216 cites W2907062500 @default.
- W4282600216 cites W2921270891 @default.
- W4282600216 cites W2922166354 @default.
- W4282600216 cites W2949892392 @default.
- W4282600216 cites W2964504184 @default.
- W4282600216 cites W2984014483 @default.
- W4282600216 cites W2986837096 @default.
- W4282600216 cites W2998363672 @default.
- W4282600216 cites W3005580638 @default.
- W4282600216 cites W3042659524 @default.
- W4282600216 cites W3089081032 @default.
- W4282600216 cites W3128040373 @default.
- W4282600216 cites W3135605731 @default.
- W4282600216 cites W3154158577 @default.
- W4282600216 cites W3155736297 @default.
- W4282600216 cites W3192725703 @default.
- W4282600216 cites W3197181042 @default.
- W4282600216 doi "https://doi.org/10.1121/10.0011510" @default.
- W4282600216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35778165" @default.
- W4282600216 hasPublicationYear "2022" @default.
- W4282600216 type Work @default.
- W4282600216 citedByCount "7" @default.
- W4282600216 countsByYear W42826002162022 @default.
- W4282600216 countsByYear W42826002162023 @default.
- W4282600216 crossrefType "journal-article" @default.
- W4282600216 hasAuthorship W4282600216A5014284262 @default.
- W4282600216 hasAuthorship W4282600216A5027728332 @default.
- W4282600216 hasAuthorship W4282600216A5049259708 @default.