FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282822450> ?p ?o ?g. }

• W4282822450 endingPage "R40" @default.
• W4282822450 startingPage "R27" @default.
• W4282822450 abstract "Adrenocortical carcinoma (ACC) accounts for a minority of all malignant tumors in adults. Surgery remains the most important therapeutic option for non-metastatic ACC. Whether a subset of patients with small ACC may benefit from minimally invasive surgery remains a debated issue, but we believe that surgeon’s expertise is more important than surgical technique to determine outcome. However, even a state-of-the-art surgery cannot prevent disease recurrence that is determined mainly by specific tumor characteristics. We consider that the concomitant presence of the following features characterizes a cohort of patients at low risk of recurrence, (i) R0 resection (microscopically free margin), (ii) localized disease (stage I-II ACC), and (iii) low-grade tumor (ki-67 <10%). After the ADIUVO study, we do not recommend adjuvant mitotane as a routine measure for such patients, who can be managed with active surveillance thus sparing a toxic treatment. Patients at average risk of recurrence should be treated with adjuvant mitotane. For patients at very high risk of recurrence, defined as the presence of at least one of the following: Ki67 >30%, large venous tumor thrombus, R1 resection or stage IV ACC, we increasingly recommend to combine mitotane with four cycles of platinum-based chemotherapy. However, patients at moderate-to-high risk of recurrence should be ideally enrolled in the ongoing ADIUVO2 trial. We do not use adjuvant radiotherapy of the tumor bed frequently at our institutions, and we select patients with incomplete resection, either microscopically or macroscopically, for this treatment. In the long-term, prospective multicenter trials are required to improve patient care." @default.
• W4282822450 created "2022-06-15" @default.
• W4282822450 creator A5003946700 @default.
• W4282822450 creator A5016606339 @default.
• W4282822450 date "2022-09-01" @default.
• W4282822450 modified "2023-10-15" @default.
• W4282822450 title "ENDOCRINE TUMOURS: Our experience with the management of patients with non-metastatic adrenocortical carcinoma" @default.
• W4282822450 cites W1964619217 @default.
• W4282822450 cites W1976454566 @default.
• W4282822450 cites W1994325777 @default.
• W4282822450 cites W1995124360 @default.
• W4282822450 cites W2003894552 @default.
• W4282822450 cites W2007474279 @default.
• W4282822450 cites W2009667972 @default.
• W4282822450 cites W2010908714 @default.
• W4282822450 cites W2034712686 @default.
• W4282822450 cites W2042271589 @default.
• W4282822450 cites W2048059530 @default.
• W4282822450 cites W2056952305 @default.
• W4282822450 cites W2080838501 @default.
• W4282822450 cites W2082740411 @default.
• W4282822450 cites W2085986924 @default.
• W4282822450 cites W2096051245 @default.
• W4282822450 cites W2096859456 @default.
• W4282822450 cites W2097666366 @default.
• W4282822450 cites W2098622295 @default.
• W4282822450 cites W2102885350 @default.
• W4282822450 cites W2106037975 @default.
• W4282822450 cites W2114210346 @default.
• W4282822450 cites W2122095127 @default.
• W4282822450 cites W2138814076 @default.
• W4282822450 cites W2140991656 @default.
• W4282822450 cites W2142931016 @default.
• W4282822450 cites W2145168501 @default.
• W4282822450 cites W2147453254 @default.
• W4282822450 cites W2164015349 @default.
• W4282822450 cites W2166261257 @default.
• W4282822450 cites W2175623323 @default.
• W4282822450 cites W2197568043 @default.
• W4282822450 cites W2254146042 @default.
• W4282822450 cites W2274958028 @default.
• W4282822450 cites W2311264853 @default.
• W4282822450 cites W2313404117 @default.
• W4282822450 cites W2346239022 @default.
• W4282822450 cites W2469640494 @default.
• W4282822450 cites W2730992908 @default.
• W4282822450 cites W2770128445 @default.
• W4282822450 cites W2774408706 @default.
• W4282822450 cites W2793971568 @default.
• W4282822450 cites W2797227515 @default.
• W4282822450 cites W2808884452 @default.
• W4282822450 cites W2883682970 @default.
• W4282822450 cites W2900476842 @default.
• W4282822450 cites W2911939639 @default.
• W4282822450 cites W2937296959 @default.
• W4282822450 cites W2939345169 @default.
• W4282822450 cites W2956797276 @default.
• W4282822450 cites W2993074022 @default.
• W4282822450 cites W3015595266 @default.
• W4282822450 cites W3031343722 @default.
• W4282822450 cites W3081691533 @default.
• W4282822450 cites W3091239067 @default.
• W4282822450 cites W3091939690 @default.
• W4282822450 cites W3135174548 @default.
• W4282822450 cites W3142784366 @default.
• W4282822450 cites W3177631313 @default.
• W4282822450 cites W3195278897 @default.
• W4282822450 cites W3211317389 @default.
• W4282822450 cites W4200224477 @default.
• W4282822450 cites W4205850912 @default.
• W4282822450 cites W4210321982 @default.
• W4282822450 doi "https://doi.org/10.1530/eje-22-0260" @default.
• W4282822450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35695575" @default.
• W4282822450 hasPublicationYear "2022" @default.
• W4282822450 type Work @default.
• W4282822450 citedByCount "9" @default.
• W4282822450 countsByYear W42828224502022 @default.
• W4282822450 countsByYear W42828224502023 @default.
• W4282822450 crossrefType "journal-article" @default.
• W4282822450 hasAuthorship W4282822450A5003946700 @default.
• W4282822450 hasAuthorship W4282822450A5016606339 @default.
• W4282822450 hasBestOaLocation W42828224501 @default.
• W4282822450 hasConcept C126322002 @default.
• W4282822450 hasConcept C141071460 @default.
• W4282822450 hasConcept C143998085 @default.
• W4282822450 hasConcept C146357865 @default.
• W4282822450 hasConcept C151730666 @default.
• W4282822450 hasConcept C2776694085 @default.
• W4282822450 hasConcept C2776735609 @default.
• W4282822450 hasConcept C2777863537 @default.
• W4282822450 hasConcept C2779134260 @default.
• W4282822450 hasConcept C2779384505 @default.
• W4282822450 hasConcept C2781399356 @default.
• W4282822450 hasConcept C509974204 @default.
• W4282822450 hasConcept C71924100 @default.
• W4282822450 hasConcept C72563966 @default.
• W4282822450 hasConcept C86803240 @default.
• W4282822450 hasConceptScore W4282822450C126322002 @default.

• next