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- W4282825603 abstract "Since the identification of sickle cell trait as a heritable form of resistance to malaria, candidate gene studies, linkage analysis paired with sequencing, and genome-wide association (GWA) studies have revealed many examples of genetic resistance and susceptibility to infectious diseases. GWA studies enabled the identification of many common variants associated with small shifts in susceptibility to infectious diseases. This is exemplified by multiple loci associated with leprosy, malaria, HIV, tuberculosis, and coronavirus disease 2019 (COVID-19), which illuminate genetic architecture and implicate pathways underlying pathophysiology. Despite these successes, most of the heritability of infectious diseases remains to be explained. As the field advances, current limitations may be overcome by applying methodological innovations such as cellular GWA studies and phenome-wide association (PheWA) studies as well as by improving methodological rigor with more precise case definitions, deeper phenotyping, increased cohort diversity, and functional validation of candidate loci in the laboratory or human challenge studies." @default.
- W4282825603 created "2022-06-15" @default.
- W4282825603 creator A5065085690 @default.
- W4282825603 creator A5085654664 @default.
- W4282825603 creator A5088338768 @default.
- W4282825603 date "2022-11-30" @default.
- W4282825603 modified "2023-09-26" @default.
- W4282825603 title "The Awesome Power of Human Genetics of Infectious Disease" @default.
- W4282825603 cites W1501734645 @default.
- W4282825603 cites W1515527087 @default.
- W4282825603 cites W1533942137 @default.
- W4282825603 cites W1559389386 @default.
- W4282825603 cites W1602670622 @default.
- W4282825603 cites W1856196215 @default.
- W4282825603 cites W1965019797 @default.
- W4282825603 cites W1973806732 @default.
- W4282825603 cites W1974397205 @default.
- W4282825603 cites W1977853360 @default.
- W4282825603 cites W1978297432 @default.
- W4282825603 cites W1981440980 @default.
- W4282825603 cites W1981644527 @default.
- W4282825603 cites W1986574361 @default.
- W4282825603 cites W1992455678 @default.
- W4282825603 cites W1992890129 @default.
- W4282825603 cites W1994367842 @default.
- W4282825603 cites W1996183144 @default.
- W4282825603 cites W1997072127 @default.
- W4282825603 cites W2000189931 @default.
- W4282825603 cites W2007021820 @default.
- W4282825603 cites W2009178411 @default.
- W4282825603 cites W2012697072 @default.
- W4282825603 cites W2014415815 @default.
- W4282825603 cites W2015177444 @default.
- W4282825603 cites W2024412831 @default.
- W4282825603 cites W2025733005 @default.
- W4282825603 cites W2025943989 @default.
- W4282825603 cites W2026014108 @default.
- W4282825603 cites W2026444780 @default.
- W4282825603 cites W2036182565 @default.
- W4282825603 cites W2043901802 @default.
- W4282825603 cites W2045921037 @default.
- W4282825603 cites W2046414350 @default.
- W4282825603 cites W2055186636 @default.
- W4282825603 cites W2058454627 @default.
- W4282825603 cites W2063285149 @default.
- W4282825603 cites W2066609936 @default.
- W4282825603 cites W2068115215 @default.
- W4282825603 cites W2073204194 @default.
- W4282825603 cites W2077418900 @default.
- W4282825603 cites W2080896009 @default.
- W4282825603 cites W2088380202 @default.
- W4282825603 cites W2090630729 @default.
- W4282825603 cites W2091229884 @default.
- W4282825603 cites W2099198339 @default.
- W4282825603 cites W2101429325 @default.
- W4282825603 cites W2101939625 @default.
- W4282825603 cites W2105753511 @default.
- W4282825603 cites W2112087830 @default.
- W4282825603 cites W2113784410 @default.
- W4282825603 cites W2122515336 @default.
- W4282825603 cites W2125524975 @default.
- W4282825603 cites W2128718394 @default.
- W4282825603 cites W2131376910 @default.
- W4282825603 cites W2135254713 @default.
- W4282825603 cites W2135424108 @default.
- W4282825603 cites W2136078375 @default.
- W4282825603 cites W2136369890 @default.
- W4282825603 cites W2138362866 @default.
- W4282825603 cites W2146099217 @default.
- W4282825603 cites W2146130945 @default.
- W4282825603 cites W2147786362 @default.
- W4282825603 cites W2150285359 @default.
- W4282825603 cites W2150527785 @default.
- W4282825603 cites W2154218327 @default.
- W4282825603 cites W2157376708 @default.
- W4282825603 cites W2157752701 @default.
- W4282825603 cites W2159367931 @default.
- W4282825603 cites W2165959932 @default.
- W4282825603 cites W2167654243 @default.
- W4282825603 cites W2168945881 @default.
- W4282825603 cites W2169759536 @default.
- W4282825603 cites W2217809488 @default.
- W4282825603 cites W2300810117 @default.
- W4282825603 cites W2313820419 @default.
- W4282825603 cites W2341817708 @default.
- W4282825603 cites W2381299150 @default.
- W4282825603 cites W2532435486 @default.
- W4282825603 cites W2538361155 @default.
- W4282825603 cites W2547161721 @default.
- W4282825603 cites W2547580314 @default.
- W4282825603 cites W2566747786 @default.
- W4282825603 cites W2584757174 @default.
- W4282825603 cites W2613064815 @default.
- W4282825603 cites W2626195186 @default.
- W4282825603 cites W2626606138 @default.
- W4282825603 cites W2747041325 @default.
- W4282825603 cites W2757215294 @default.
- W4282825603 cites W2757687594 @default.