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- W4282825676 endingPage "2447" @default.
- W4282825676 startingPage "2447" @default.
- W4282825676 abstract "Calcifediol is the prohormone of the vitamin D endocrine system (VDES). It requires hydroxylation to move to 1,25(OH)2D3 or calcitriol, the active form that exerts its functions by activating the vitamin D receptor (VDR) that is expressed in many organs, including the lungs. Due to its rapid oral absorption and because it does not require first hepatic hydroxylation, it is a good option to replace the prevalent deficiency of vitamin D (25 hydroxyvitamin D; 25OHD), to which patients with respiratory pathologies are no strangers. Correcting 25OHD deficiency can decrease the risk of upper respiratory infections and thus improve asthma and COPD control. The same happens with other respiratory pathologies and, in particular, COVID-19. Calcifediol may be a good option for raising 25OHD serum levels quickly because the profile of inflammatory cytokines exhibited by patients with inflammatory respiratory diseases, such as asthma, COPD or COVID-19, can increase the degradation of the active metabolites of the VDES. The aim of this narrative revision is to report the current evidence on the role of calcifediol in main respiratory diseases. In conclusion, good 25OHD status may have beneficial effects on the clinical course of respiratory diseases, including COVID-19. This hypothesis should be confirmed in large, randomized trials. Otherwise, a rapid correction of 25(OH)D deficiency can be useful for patients with respiratory disease." @default.
- W4282825676 created "2022-06-15" @default.
- W4282825676 creator A5013115420 @default.
- W4282825676 creator A5068710948 @default.
- W4282825676 creator A5077693938 @default.
- W4282825676 creator A5090864849 @default.
- W4282825676 date "2022-06-13" @default.
- W4282825676 modified "2023-10-16" @default.
- W4282825676 title "Calcifediol for Use in Treatment of Respiratory Disease" @default.
- W4282825676 cites W1588874156 @default.
- W4282825676 cites W1590458514 @default.
- W4282825676 cites W1599765837 @default.
- W4282825676 cites W1924205224 @default.
- W4282825676 cites W1963871427 @default.
- W4282825676 cites W1967337920 @default.
- W4282825676 cites W1970927010 @default.
- W4282825676 cites W1974327741 @default.
- W4282825676 cites W1976776496 @default.
- W4282825676 cites W1979471324 @default.
- W4282825676 cites W1985073208 @default.
- W4282825676 cites W1988732516 @default.
- W4282825676 cites W1994006843 @default.
- W4282825676 cites W1994698540 @default.
- W4282825676 cites W1998606050 @default.
- W4282825676 cites W2001654461 @default.
- W4282825676 cites W2002613205 @default.
- W4282825676 cites W2003057279 @default.
- W4282825676 cites W2012029286 @default.
- W4282825676 cites W2016939538 @default.
- W4282825676 cites W2029625174 @default.
- W4282825676 cites W2032945790 @default.
- W4282825676 cites W2036589635 @default.
- W4282825676 cites W2045279683 @default.
- W4282825676 cites W2047688409 @default.
- W4282825676 cites W2050040365 @default.
- W4282825676 cites W2050237494 @default.
- W4282825676 cites W2059014306 @default.
- W4282825676 cites W2060343427 @default.
- W4282825676 cites W2069316257 @default.
- W4282825676 cites W2088340450 @default.
- W4282825676 cites W2089123479 @default.
- W4282825676 cites W2096771737 @default.
- W4282825676 cites W2098204477 @default.
- W4282825676 cites W2103010959 @default.
- W4282825676 cites W2114301704 @default.
- W4282825676 cites W2116296059 @default.
- W4282825676 cites W2118889444 @default.
- W4282825676 cites W2122003737 @default.
- W4282825676 cites W2122515787 @default.
- W4282825676 cites W2124070987 @default.
- W4282825676 cites W2124580054 @default.
- W4282825676 cites W2133566780 @default.
- W4282825676 cites W2134744881 @default.
- W4282825676 cites W2136083733 @default.
- W4282825676 cites W2144422991 @default.
- W4282825676 cites W2146523219 @default.
- W4282825676 cites W2152905836 @default.
- W4282825676 cites W2158391515 @default.
- W4282825676 cites W2158729369 @default.
- W4282825676 cites W2162895883 @default.
- W4282825676 cites W2163507707 @default.
- W4282825676 cites W2168924121 @default.
- W4282825676 cites W2170390325 @default.
- W4282825676 cites W2400119305 @default.
- W4282825676 cites W2536477161 @default.
- W4282825676 cites W2581417895 @default.
- W4282825676 cites W2588906490 @default.
- W4282825676 cites W2590576911 @default.
- W4282825676 cites W2604521268 @default.
- W4282825676 cites W2607896389 @default.
- W4282825676 cites W2737961213 @default.
- W4282825676 cites W2753866383 @default.
- W4282825676 cites W2754519281 @default.
- W4282825676 cites W2761444033 @default.
- W4282825676 cites W2763472604 @default.
- W4282825676 cites W2765289238 @default.
- W4282825676 cites W2802139175 @default.
- W4282825676 cites W2802788160 @default.
- W4282825676 cites W2808737659 @default.
- W4282825676 cites W2808823912 @default.
- W4282825676 cites W2883473185 @default.
- W4282825676 cites W2890211704 @default.
- W4282825676 cites W2891859264 @default.
- W4282825676 cites W2896178057 @default.
- W4282825676 cites W2901751456 @default.
- W4282825676 cites W2909497687 @default.
- W4282825676 cites W2912546399 @default.
- W4282825676 cites W2917559279 @default.
- W4282825676 cites W2922650826 @default.
- W4282825676 cites W2942508685 @default.
- W4282825676 cites W3011155184 @default.
- W4282825676 cites W3013463190 @default.
- W4282825676 cites W3014849016 @default.
- W4282825676 cites W3022264226 @default.
- W4282825676 cites W3022354617 @default.
- W4282825676 cites W3031629421 @default.
- W4282825676 cites W3035236769 @default.
- W4282825676 cites W3035473263 @default.