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- W4282829655 abstract "Immune checkpoint inhibitors (ICIs) have dramatically transformed oncology by prolonging overall survival and yielding better patient tolerance compared to other chemotherapeutic agents. However, numerous questions remain unanswered about the toxicity profile of ICIs, its relationship with the treatment response, and causes underlying the excellent treatment response in some patients, while recalcitrance in others. Research groups have continued to seek biomarkers that may permit the identification of treatment responders and predict toxicity to facilitate cessation of immunotherapy before the development of severe toxicity. However, some studies have found associations between serious adverse events and longer survivorship. The research question entailed determining whether a biomarker is needed to predict severe immune-related adverse events prior to their development or whether providing early treatment for toxicity would inhibit the immune system from attaining a long-lasting anti-tumor effect. Therefore, this review conducted an in-depth analysis into the molecular basis of these observations." @default.
- W4282829655 created "2022-06-15" @default.
- W4282829655 creator A5001820544 @default.
- W4282829655 creator A5019060309 @default.
- W4282829655 date "2022-06-14" @default.
- W4282829655 modified "2023-10-01" @default.
- W4282829655 title "Predictive Biomarkers of Severe Immune-Related Adverse Events With Immune Checkpoint Inhibitors: Prevention, Underlying Causes, Intensity, and Consequences" @default.
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- W4282829655 doi "https://doi.org/10.3389/fmed.2022.908752" @default.
- W4282829655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35774996" @default.
- W4282829655 hasPublicationYear "2022" @default.
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