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• W4282830110 endingPage "1255" @default.
• W4282830110 startingPage "1255" @default.
• W4282830110 abstract "Daily administration of multiple injections can cause inconvenience and reduce compliance in diabetic patients; thus, microneedle (MN) administration is favored due to its various advantages. Accordingly, the two-layer sustained-release MNs (TS-MNs) were fabricated by encapsulating exenatide (EXT) in calcium alginate (CA) gel in this work. The TS-MNs were composed of a sodium alginate (SA) tip and a water-soluble matrix-containing calcium chloride (CaCl2). Subsequently, the calcium ion (Ca2+) contained in the matrix layer penetrated the tip layer for cross-linking, leaving the drug in the cross-linked network. The patches have adequate mechanical strength to pierce the skin; then, the matrix layer is dissolved, leaving the tip layer to achieve sustained release. Additionally, the TS-MNs encapsulating EXT retained high activity during long-term storage at room temperature. The pharmacokinetic results indicated that the plasma concentrations of EXT were sustained for 48 h in the EXT MN group, which agreed with the in vitro release test. Furthermore, they had high relative bioavailability (83.04%). Moreover, the hypoglycemic effect was observed to last for approximately 24 h after a single administration and remained effective after multiple administrations without drug resistance. These results suggest that the TS-MNs are a promising depot for the sustained delivery of encapsulated EXT." @default.
• W4282830110 created "2022-06-15" @default.
• W4282830110 creator A5020083561 @default.
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• W4282830110 date "2022-06-13" @default.
• W4282830110 modified "2023-09-25" @default.
• W4282830110 title "Two-Layer Sustained-Release Microneedles Encapsulating Exenatide for Type 2 Diabetes Treatment" @default.
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• W4282830110 doi "https://doi.org/10.3390/pharmaceutics14061255" @default.
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