Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282831080> ?p ?o ?g. }
- W4282831080 endingPage "1247" @default.
- W4282831080 startingPage "1247" @default.
- W4282831080 abstract "Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. SARS-CoV-2 is characterized by an important capacity to circumvent the innate immune response. The early interferon (IFN) response is necessary to establish a robust antiviral state. However, this response is weak and delayed in COVID-19 patients, along with massive pro-inflammatory cytokine production. This dysregulated innate immune response contributes to pathogenicity and in some individuals leads to a critical state. Characterizing the interplay between viral factors and host innate immunity is crucial to better understand how to manage the disease. Moreover, the constant emergence of new SARS-CoV-2 variants challenges the efficacy of existing vaccines. Thus, to control this virus and readjust the antiviral therapy currently used to treat COVID-19, studies should constantly be re-evaluated to further decipher the mechanisms leading to SARS-CoV-2 pathogenesis. Regarding the role of the IFN response in SARS-CoV-2 infection, in this review we summarize the mechanisms by which SARS-CoV-2 evades innate immune recognition. More specifically, we explain how this virus inhibits IFN signaling pathways (IFN-I/IFN-III) and controls interferon-stimulated gene (ISG) expression. We also discuss the development and use of IFNs and potential drugs controlling the innate immune response to SARS-CoV-2, helping to clear the infection." @default.
- W4282831080 created "2022-06-15" @default.
- W4282831080 creator A5021426765 @default.
- W4282831080 creator A5033183601 @default.
- W4282831080 creator A5033930684 @default.
- W4282831080 creator A5069063356 @default.
- W4282831080 date "2022-06-08" @default.
- W4282831080 modified "2023-10-05" @default.
- W4282831080 title "Characterization of SARS-CoV-2 Evasion: Interferon Pathway and Therapeutic Options" @default.
- W4282831080 cites W1970232220 @default.
- W4282831080 cites W1972381161 @default.
- W4282831080 cites W1973646620 @default.
- W4282831080 cites W1980969179 @default.
- W4282831080 cites W1991082528 @default.
- W4282831080 cites W2002117801 @default.
- W4282831080 cites W2009769910 @default.
- W4282831080 cites W2046310800 @default.
- W4282831080 cites W2063310200 @default.
- W4282831080 cites W2066680385 @default.
- W4282831080 cites W2082632613 @default.
- W4282831080 cites W2089077517 @default.
- W4282831080 cites W2099866950 @default.
- W4282831080 cites W2115617484 @default.
- W4282831080 cites W2133402546 @default.
- W4282831080 cites W2209458064 @default.
- W4282831080 cites W2261043905 @default.
- W4282831080 cites W2274721624 @default.
- W4282831080 cites W2517547699 @default.
- W4282831080 cites W2616524644 @default.
- W4282831080 cites W2745352569 @default.
- W4282831080 cites W2798242933 @default.
- W4282831080 cites W2917493275 @default.
- W4282831080 cites W2931678155 @default.
- W4282831080 cites W2936804536 @default.
- W4282831080 cites W2938754657 @default.
- W4282831080 cites W2959449984 @default.
- W4282831080 cites W2970141704 @default.
- W4282831080 cites W3001118548 @default.
- W4282831080 cites W3003217347 @default.
- W4282831080 cites W3004280078 @default.
- W4282831080 cites W3005838342 @default.
- W4282831080 cites W3009885589 @default.
- W4282831080 cites W3011134208 @default.
- W4282831080 cites W3016467573 @default.
- W4282831080 cites W3016489853 @default.
- W4282831080 cites W3016636971 @default.
- W4282831080 cites W3017680297 @default.
- W4282831080 cites W3018221920 @default.
- W4282831080 cites W3021565497 @default.
- W4282831080 cites W3023475091 @default.
- W4282831080 cites W3023606094 @default.
- W4282831080 cites W3025395896 @default.
- W4282831080 cites W3034927885 @default.
- W4282831080 cites W3036784522 @default.
- W4282831080 cites W3036912690 @default.
- W4282831080 cites W3037578804 @default.
- W4282831080 cites W3041278562 @default.
- W4282831080 cites W3041960835 @default.
- W4282831080 cites W3042482358 @default.
- W4282831080 cites W3042943159 @default.
- W4282831080 cites W3043391491 @default.
- W4282831080 cites W3043399375 @default.
- W4282831080 cites W3043427328 @default.
- W4282831080 cites W3043831218 @default.
- W4282831080 cites W3044220214 @default.
- W4282831080 cites W3044799813 @default.
- W4282831080 cites W3045756756 @default.
- W4282831080 cites W3045802278 @default.
- W4282831080 cites W3046218096 @default.
- W4282831080 cites W3081073771 @default.
- W4282831080 cites W3082709602 @default.
- W4282831080 cites W3083872269 @default.
- W4282831080 cites W3085062170 @default.
- W4282831080 cites W3085718285 @default.
- W4282831080 cites W3087744389 @default.
- W4282831080 cites W3087862874 @default.
- W4282831080 cites W3088256443 @default.
- W4282831080 cites W3089955663 @default.
- W4282831080 cites W3091501889 @default.
- W4282831080 cites W3092016255 @default.
- W4282831080 cites W3092296275 @default.
- W4282831080 cites W3093094957 @default.
- W4282831080 cites W3093210439 @default.
- W4282831080 cites W3094558943 @default.
- W4282831080 cites W3094854996 @default.
- W4282831080 cites W3095032459 @default.
- W4282831080 cites W3095682175 @default.
- W4282831080 cites W3103021984 @default.
- W4282831080 cites W3103598365 @default.
- W4282831080 cites W3104688112 @default.
- W4282831080 cites W3107596380 @default.
- W4282831080 cites W3108188788 @default.
- W4282831080 cites W3110466220 @default.
- W4282831080 cites W3113243295 @default.
- W4282831080 cites W3115414062 @default.
- W4282831080 cites W3115832826 @default.
- W4282831080 cites W3116021319 @default.
- W4282831080 cites W3118761418 @default.