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- W4282834019 endingPage "234" @default.
- W4282834019 startingPage "225" @default.
- W4282834019 abstract "Psoriasis vulgaris is the commonest presentation of psoriatic disease, but morphologic variants such as pustular psoriasis (PP) and a closely related disease, pityriasis rubra pilaris (PRP), have been known for a long time, have been associated with rheumatologic manifestations indistinguishable from psoriatic arthritis (PsA) that may go unrecognized, and often represent a therapeutic conundrum. There is recent evidence that underlying genetic and pathogenetic differences may provide the basis for newer therapeutic approaches.This narrative review highlights the clinical, genetic and pathogenetic characteristics of PP and PRP, their association with PsA and recent developments in their treatment, especially with biologic agents targeting IL-36 and other cytokines of pathogenic relevance.The clinical manifestations of PP and PRP are less well known to rheumatologists than those of psoriasis, and recent advances in our insight on their pathogenesis may eventually overcome the therapeutic difficulties faced by dermatologists and rheumatologists in the management of these diseases and their rheumatologic manifestations." @default.
- W4282834019 created "2022-06-15" @default.
- W4282834019 creator A5016397232 @default.
- W4282834019 creator A5033015474 @default.
- W4282834019 date "2022-06-09" @default.
- W4282834019 modified "2023-10-12" @default.
- W4282834019 title "Beyond plaque psoriasis – pathogenesis and treatment of other psoriasis phenotypes" @default.
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