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- W4282834289 endingPage "200128" @default.
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- W4282834289 abstract "Defensins are an important class of AMPs, rich in cysteine with antibacterial, antifungal and antiviral functions. The present study identified and functionally characterised a β-defensin gene from Grey mullet, Mugil cephalus, termed as Mc-Def. A 192 base pair complementary DNA with an open reading frame encoding 63 amino acids comprising 20 amino acid signal and 43 amino acid mature peptide region was obtained. Mc-Def has a net charge of 3.9 and a molecular weight of 7.27 kDa with an isoelectric point of 8.88. It possessed six cysteines forming 3 disulphide bonds between C1–C5, C2–C4 and C3–C6. Three dimensional structure identified a short N-terminal α helix followed by β sheet strands stabilized by disulfide bonds. The mRNA structure was predicted by Biomodel server with significant MEF score. Multiple sequence alignment and phylogeny revealed the sequence similarity of Mc-Def with fish β-defensin 2 type of AMPs. Molecular diversity and evolution of β-defensin provided immunity to host system against various infections. In silico analysis identified its potential as antibacterial, antifungal, anticancer, antioxidant and non-hemolytic peptide activity. These intriguing results firmly suggest that the Mc-Def can be used as a potent drug molecule in fish health management." @default.
- W4282834289 created "2022-06-15" @default.
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- W4282834289 date "2022-08-01" @default.
- W4282834289 modified "2023-09-30" @default.
- W4282834289 title "A β-defensin isoform from the Flathead grey mullet, Mugil cephalus (Linnaeus 1758): Structural and functional characterisation in silico" @default.
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- W4282834289 doi "https://doi.org/10.1016/j.angen.2022.200128" @default.
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