Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282839013> ?p ?o ?g. }
- W4282839013 endingPage "2031" @default.
- W4282839013 startingPage "2031" @default.
- W4282839013 abstract "The molecular effects of exposures to engineered nanomaterials (ENMs) are still largely unknown. In classical inhalation toxicology, cell composition of bronchoalveolar lavage (BAL) is a toxicity indicator at the lung tissue level that can aid in interpreting pulmonary histological changes. Toxicogenomic approaches help characterize the mechanism of action (MOA) of ENMs by investigating the differentially expressed genes (DEG). However, dissecting which molecular mechanisms and events are directly induced by the exposure is not straightforward. It is now generally accepted that direct effects follow a monotonic dose-dependent pattern. Here, we applied an integrated modeling approach to study the MOA of four ENMs by retrieving the DEGs that also show a dynamic dose-dependent profile (dddtMOA). We further combined the information of the dddtMOA with the dose dependency of four immune cell populations derived from BAL counts. The dddtMOA analysis highlighted the specific adaptation pattern to each ENM. Furthermore, it revealed the distinct effect of the ENM physicochemical properties on the induced immune response. Finally, we report three genes dose-dependent in all the exposures and correlated with immune deregulation in the lung. The characterization of dddtMOA for ENM exposures, both for apical endpoints and molecular responses, can further promote toxicogenomic approaches in a regulatory context." @default.
- W4282839013 created "2022-06-15" @default.
- W4282839013 creator A5003627670 @default.
- W4282839013 creator A5011752174 @default.
- W4282839013 creator A5016513487 @default.
- W4282839013 creator A5028682033 @default.
- W4282839013 creator A5041632230 @default.
- W4282839013 creator A5048740200 @default.
- W4282839013 creator A5054987771 @default.
- W4282839013 creator A5057193559 @default.
- W4282839013 creator A5066582047 @default.
- W4282839013 date "2022-06-13" @default.
- W4282839013 modified "2023-10-01" @default.
- W4282839013 title "Characterization of ENM Dynamic Dose-Dependent MOA in Lung with Respect to Immune Cells Infiltration" @default.
- W4282839013 cites W1479909557 @default.
- W4282839013 cites W1563852071 @default.
- W4282839013 cites W1960101167 @default.
- W4282839013 cites W1963842765 @default.
- W4282839013 cites W1966657551 @default.
- W4282839013 cites W1970757672 @default.
- W4282839013 cites W2021281657 @default.
- W4282839013 cites W2035618305 @default.
- W4282839013 cites W2043548074 @default.
- W4282839013 cites W2046677507 @default.
- W4282839013 cites W2073461535 @default.
- W4282839013 cites W2076833412 @default.
- W4282839013 cites W2079132836 @default.
- W4282839013 cites W2081436744 @default.
- W4282839013 cites W2082966150 @default.
- W4282839013 cites W2098052781 @default.
- W4282839013 cites W2118610649 @default.
- W4282839013 cites W2124717298 @default.
- W4282839013 cites W2127259475 @default.
- W4282839013 cites W2127441515 @default.
- W4282839013 cites W2137665452 @default.
- W4282839013 cites W2146512944 @default.
- W4282839013 cites W2167616343 @default.
- W4282839013 cites W2167981107 @default.
- W4282839013 cites W2168015444 @default.
- W4282839013 cites W2171741011 @default.
- W4282839013 cites W2179660163 @default.
- W4282839013 cites W2273976251 @default.
- W4282839013 cites W2386383383 @default.
- W4282839013 cites W2463013315 @default.
- W4282839013 cites W2463738079 @default.
- W4282839013 cites W2471329520 @default.
- W4282839013 cites W2513217124 @default.
- W4282839013 cites W2532513964 @default.
- W4282839013 cites W2564760336 @default.
- W4282839013 cites W2604444379 @default.
- W4282839013 cites W2621092442 @default.
- W4282839013 cites W2751658215 @default.
- W4282839013 cites W2754449970 @default.
- W4282839013 cites W2761377524 @default.
- W4282839013 cites W2768648556 @default.
- W4282839013 cites W2802773414 @default.
- W4282839013 cites W2808928947 @default.
- W4282839013 cites W2889418135 @default.
- W4282839013 cites W2897133367 @default.
- W4282839013 cites W2899015035 @default.
- W4282839013 cites W2909794455 @default.
- W4282839013 cites W2909853721 @default.
- W4282839013 cites W2913930991 @default.
- W4282839013 cites W2923394609 @default.
- W4282839013 cites W2943221775 @default.
- W4282839013 cites W2944331050 @default.
- W4282839013 cites W2944600881 @default.
- W4282839013 cites W2969984461 @default.
- W4282839013 cites W2972340037 @default.
- W4282839013 cites W2988701984 @default.
- W4282839013 cites W2998919570 @default.
- W4282839013 cites W3011109876 @default.
- W4282839013 cites W3014118352 @default.
- W4282839013 cites W3015334569 @default.
- W4282839013 cites W3016893324 @default.
- W4282839013 cites W3023855676 @default.
- W4282839013 cites W3026905532 @default.
- W4282839013 cites W3038723325 @default.
- W4282839013 cites W3092854853 @default.
- W4282839013 cites W3100661518 @default.
- W4282839013 cites W3135303713 @default.
- W4282839013 cites W3144476017 @default.
- W4282839013 cites W3210244836 @default.
- W4282839013 cites W4210760577 @default.
- W4282839013 cites W4214830748 @default.
- W4282839013 doi "https://doi.org/10.3390/nano12122031" @default.
- W4282839013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35745370" @default.
- W4282839013 hasPublicationYear "2022" @default.
- W4282839013 type Work @default.
- W4282839013 citedByCount "3" @default.
- W4282839013 countsByYear W42828390132023 @default.
- W4282839013 crossrefType "journal-article" @default.
- W4282839013 hasAuthorship W4282839013A5003627670 @default.
- W4282839013 hasAuthorship W4282839013A5011752174 @default.
- W4282839013 hasAuthorship W4282839013A5016513487 @default.
- W4282839013 hasAuthorship W4282839013A5028682033 @default.
- W4282839013 hasAuthorship W4282839013A5041632230 @default.
- W4282839013 hasAuthorship W4282839013A5048740200 @default.