Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282842568> ?p ?o ?g. }
- W4282842568 abstract "Abstract Accurate and precise delineation of gross tumour volumes remains a barrier to radiotherapy dose escalation and boost dosing in the treatment of solid tumours, such as prostate cancer. Magnetic resonance imaging of tumour molecular targets has the power to enable focal dose boosting, particularly when combined with technological advances such as MRI-LINAC. Fibroblast activation protein (FAP) is a transmembrane protein overexpressed in stromal components of >90% of epithelial carcinomas. Herein we compare targeted MRI of gold standard PSMA with FAP in the delineation of orthotopic tumours in a mouse model of prostate cancer. Control (no ligand), FAP and PSMA-targeting iron oxide nanoparticles were prepared with modification of an MRI agent (FerroTrace). Mice with orthotopic LNCaP tumours underwent T 2 -weighted 3D MRI 24 hours after intravenous injection of contrast agents. FAP and PSMA nanoparticles produced contrast enhancement on MRI when compared to control nanoparticles, which was most pronounced on the tumour periphery. FAP-targeted MRI increased the proportion of tumour contrast enhancing black pixels by 13.37% when compared to PSMA. Furthermore, analysis of changes in R2 values between healthy prostates and LNCaP tumours indicated an increase in contrast enhancing pixels in the tumour border of 15%, when targeting FAP, in contrast to PSMA This study demonstrates preclinical feasibility of PSMA and FAP-targeted MRI which can enable targeted image-guided focal therapy of localized prostate cancer." @default.
- W4282842568 created "2022-06-15" @default.
- W4282842568 creator A5006037164 @default.
- W4282842568 creator A5013636515 @default.
- W4282842568 creator A5014120936 @default.
- W4282842568 creator A5015543670 @default.
- W4282842568 creator A5052638874 @default.
- W4282842568 creator A5058004313 @default.
- W4282842568 creator A5070836824 @default.
- W4282842568 creator A5072380437 @default.
- W4282842568 creator A5081314882 @default.
- W4282842568 creator A5088959517 @default.
- W4282842568 creator A5089609044 @default.
- W4282842568 date "2022-06-12" @default.
- W4282842568 modified "2023-10-16" @default.
- W4282842568 title "Nanoparticles targeted to fibroblast activation protein outperform PSMA for MRI delineation of primary prostate tumours" @default.
- W4282842568 cites W1485208459 @default.
- W4282842568 cites W1490266165 @default.
- W4282842568 cites W1892627793 @default.
- W4282842568 cites W1972835273 @default.
- W4282842568 cites W1981328412 @default.
- W4282842568 cites W1992743783 @default.
- W4282842568 cites W2012034410 @default.
- W4282842568 cites W2022480051 @default.
- W4282842568 cites W2026386668 @default.
- W4282842568 cites W2028726843 @default.
- W4282842568 cites W2033645471 @default.
- W4282842568 cites W2043396435 @default.
- W4282842568 cites W2096764577 @default.
- W4282842568 cites W2099540110 @default.
- W4282842568 cites W2106515184 @default.
- W4282842568 cites W2142401479 @default.
- W4282842568 cites W2147091770 @default.
- W4282842568 cites W2165244734 @default.
- W4282842568 cites W2265950305 @default.
- W4282842568 cites W2326657743 @default.
- W4282842568 cites W2523030593 @default.
- W4282842568 cites W2546110733 @default.
- W4282842568 cites W2548464066 @default.
- W4282842568 cites W2558473966 @default.
- W4282842568 cites W2577453388 @default.
- W4282842568 cites W2581677089 @default.
- W4282842568 cites W2619415152 @default.
- W4282842568 cites W2724221128 @default.
- W4282842568 cites W2767431474 @default.
- W4282842568 cites W2769074396 @default.
- W4282842568 cites W2775769660 @default.
- W4282842568 cites W2794421691 @default.
- W4282842568 cites W2794782942 @default.
- W4282842568 cites W2896613406 @default.
- W4282842568 cites W2898317973 @default.
- W4282842568 cites W2904575729 @default.
- W4282842568 cites W2915254945 @default.
- W4282842568 cites W2923547516 @default.
- W4282842568 cites W2968752756 @default.
- W4282842568 cites W2980890130 @default.
- W4282842568 cites W2981509235 @default.
- W4282842568 cites W2994111536 @default.
- W4282842568 cites W2994487010 @default.
- W4282842568 cites W2998882776 @default.
- W4282842568 cites W3021215586 @default.
- W4282842568 cites W3025387589 @default.
- W4282842568 cites W3028304854 @default.
- W4282842568 cites W3032404152 @default.
- W4282842568 cites W3041930051 @default.
- W4282842568 cites W3092506186 @default.
- W4282842568 cites W3116201895 @default.
- W4282842568 cites W3125222626 @default.
- W4282842568 cites W3127146229 @default.
- W4282842568 cites W3128027682 @default.
- W4282842568 cites W3128646645 @default.
- W4282842568 cites W3145783279 @default.
- W4282842568 cites W3174294541 @default.
- W4282842568 cites W3176440091 @default.
- W4282842568 cites W3180431563 @default.
- W4282842568 cites W3193347267 @default.
- W4282842568 cites W3217030825 @default.
- W4282842568 cites W4220701830 @default.
- W4282842568 cites W4225716262 @default.
- W4282842568 cites W4226435061 @default.
- W4282842568 doi "https://doi.org/10.1101/2022.06.10.495719" @default.
- W4282842568 hasPublicationYear "2022" @default.
- W4282842568 type Work @default.
- W4282842568 citedByCount "1" @default.
- W4282842568 countsByYear W42828425682023 @default.
- W4282842568 crossrefType "posted-content" @default.
- W4282842568 hasAuthorship W4282842568A5006037164 @default.
- W4282842568 hasAuthorship W4282842568A5013636515 @default.
- W4282842568 hasAuthorship W4282842568A5014120936 @default.
- W4282842568 hasAuthorship W4282842568A5015543670 @default.
- W4282842568 hasAuthorship W4282842568A5052638874 @default.
- W4282842568 hasAuthorship W4282842568A5058004313 @default.
- W4282842568 hasAuthorship W4282842568A5070836824 @default.
- W4282842568 hasAuthorship W4282842568A5072380437 @default.
- W4282842568 hasAuthorship W4282842568A5081314882 @default.
- W4282842568 hasAuthorship W4282842568A5088959517 @default.
- W4282842568 hasAuthorship W4282842568A5089609044 @default.
- W4282842568 hasBestOaLocation W42828425681 @default.
- W4282842568 hasConcept C111798993 @default.
- W4282842568 hasConcept C121608353 @default.