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- W4282843670 abstract "Impact of abnormal nocturnal blood pressure (BP) dipping pattern on cognitive impairment and/or dementia is uncertain. The aim is to review the association between abnormal nocturnal BP dipping patterns (extreme dipping, non-dipping, or reverse dipping) and cognitive impairment and/or dementia in adults.PubMed, MEDLINE, and EMBASE databases were systematically searched. Primary outcome was pooled odds ratios for cognitive impairment/dementia between normal and abnormal dipping patterns. Secondary outcomes were pooled mean Mini-Mental State Exam score among normal and abnormal dipping patterns, and pooled mean nocturnal dipping percentage among study participants with normal and low cognitive function.When compared to normal dippers, reverse dippers have the strongest association with cognitive impairment/dementia (OR 5.56, 95%-CI 2.39-13.0, p = 0.0016) followed by non-dippers (OR 2.49, 95%-CI 1.39-4.45, p = 0.006). Association between extreme dippers and cognitive impairment/dementia was not statistically significant (OR 2.70 (95%-CI 0.80-9.12, p = 0.0904). The pooled mean Mini-Mental State Exam score among the non-dippers (26.8, 95%-CI 20.2 - 33.5) were lower than the normal dippers (27.4, 95%-CI 23.1-31.6). The standardized mean difference between the two groups was not significant (SMD -0.0694, 95%-CI -0.4998-0.361, p = 0.677). The pooled mean nocturnal dipping percentage among study participants with low cognitive function was (8.24%, 95%-CI 5.21-11.3) less than study participants with normal cognitive function (11.5%, 95%-CI 8.83-14.1). Similarly, the standard mean difference of mean nocturnal dipping percentage between the two groups was not significant (SMD -0.934, 95%-CI -2.053-0.186, p = 0.0906).Abnormal nocturnal dipping pattern may be a risk factor for cognitive impairment/dementia. Multiple included studies with cross-sectional data sets precludes drawing valid causal inference between dipping pattern and cognitive impairment." @default.
- W4282843670 created "2022-06-15" @default.
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- W4282843670 date "2022-06-01" @default.
- W4282843670 modified "2023-10-18" @default.
- W4282843670 title "ABNORMAL DIPPING PATTERN OF NOCTURNAL BLOOD PRESSURE AS A PREDICTOR OF COGNITIVE IMPAIRMENT AND/OR DEMENTIA: A SYSTEMATIC REVIEW AND META-ANALYSIS" @default.
- W4282843670 doi "https://doi.org/10.1097/01.hjh.0000836808.26201.35" @default.
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