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• W4282843805 abstract "In the initial stage of respiratory infection, Mycobacterium tuberculosis traverses from alveolar macrophages to phenotypically diverse monocyte-derived phagocytes and neutrophils in the lung parenchyma. Here, we compare the in vivo kinetics of early bacterial growth and cell-to-cell spread of two strains of M. tuberculosis: a lineage 2 strain, 4334, and the widely studied lineage 4 strain H37Rv. Using flow cytometry, live cell sorting of phenotypic subsets, and quantitation of bacteria in cells of the distinct subsets, we found that 4334 induces less leukocyte influx into the lungs but demonstrates earlier population expansion and cell-to-cell spread. The earlier spread of 4334 to recruited cells, including monocyte-derived dendritic cells, is accompanied by earlier and greater magnitude of CD4+ T cell activation. The results provide evidence that strain-specific differences in interactions with lung leukocytes can shape adaptive immune responses in vivo. IMPORTANCE Tuberculosis is a leading infectious disease killer worldwide and is caused by Mycobacterium tuberculosis. After exposure to M. tuberculosis, outcomes range from apparent elimination to active disease. Early innate immune responses may contribute to differences in outcomes, yet it is not known how bacterial strains alter the early dynamics of innate immune and T cell responses. We infected mice with distinct strains of M. tuberculosis and discovered striking differences in innate cellular recruitment, cell-to-cell spread of bacteria in the lungs, and kinetics of initiation of antigen-specific CD4 T cell responses. We also found that M. tuberculosis can spread beyond alveolar macrophages even before a large influx of inflammatory cells. These results provide evidence that distinct strains of M. tuberculosis can exhibit differential kinetics in cell-to-cell spread which is not directly linked to early recruitment of phagocytes but is subsequently linked to adaptive immune responses." @default.
• W4282843805 created "2022-06-15" @default.
• W4282843805 creator A5002545836 @default.
• W4282843805 creator A5017527950 @default.
• W4282843805 creator A5021836546 @default.
• W4282843805 creator A5048139621 @default.
• W4282843805 creator A5049252966 @default.
• W4282843805 creator A5049956452 @default.
• W4282843805 creator A5062150021 @default.
• W4282843805 date "2022-06-28" @default.
• W4282843805 modified "2023-09-26" @default.
• W4282843805 title "Bacterial Strain–Dependent Dissociation of Cell Recruitment and Cell-to-Cell Spread in Early M. tuberculosis Infection" @default.
• W4282843805 cites W1452033031 @default.
• W4282843805 cites W1537903189 @default.
• W4282843805 cites W1552410459 @default.
• W4282843805 cites W1798681852 @default.
• W4282843805 cites W1827857989 @default.
• W4282843805 cites W1838101013 @default.
• W4282843805 cites W1878928498 @default.
• W4282843805 cites W1909986873 @default.
• W4282843805 cites W1920434477 @default.
• W4282843805 cites W1975732755 @default.
• W4282843805 cites W1977138279 @default.
• W4282843805 cites W1999412329 @default.
• W4282843805 cites W2002003992 @default.
• W4282843805 cites W2010819095 @default.
• W4282843805 cites W2014623764 @default.
• W4282843805 cites W2017756984 @default.
• W4282843805 cites W2020588519 @default.
• W4282843805 cites W2036564362 @default.
• W4282843805 cites W2039955522 @default.
• W4282843805 cites W2045408415 @default.
• W4282843805 cites W2056045766 @default.
• W4282843805 cites W2057645972 @default.
• W4282843805 cites W2058051642 @default.
• W4282843805 cites W2058417246 @default.
• W4282843805 cites W2064964564 @default.
• W4282843805 cites W2067579914 @default.
• W4282843805 cites W2068563442 @default.
• W4282843805 cites W2072680575 @default.
• W4282843805 cites W2073977907 @default.
• W4282843805 cites W2074862238 @default.
• W4282843805 cites W2093294340 @default.
• W4282843805 cites W2093631337 @default.
• W4282843805 cites W2100872199 @default.
• W4282843805 cites W2103000007 @default.
• W4282843805 cites W2105622887 @default.
• W4282843805 cites W2106726809 @default.
• W4282843805 cites W2107352390 @default.
• W4282843805 cites W2109484445 @default.
• W4282843805 cites W2114493474 @default.
• W4282843805 cites W2117745740 @default.
• W4282843805 cites W2120440353 @default.
• W4282843805 cites W2121499583 @default.
• W4282843805 cites W2123058014 @default.
• W4282843805 cites W2126514499 @default.
• W4282843805 cites W2130046741 @default.
• W4282843805 cites W2134209103 @default.
• W4282843805 cites W2134425543 @default.
• W4282843805 cites W2135375332 @default.
• W4282843805 cites W2137670912 @default.
• W4282843805 cites W2138989146 @default.
• W4282843805 cites W2141077333 @default.
• W4282843805 cites W2141681443 @default.
• W4282843805 cites W2141939334 @default.
• W4282843805 cites W2143488564 @default.
• W4282843805 cites W2151586546 @default.
• W4282843805 cites W2153247828 @default.
• W4282843805 cites W2156298917 @default.
• W4282843805 cites W2162815684 @default.
• W4282843805 cites W2167405605 @default.
• W4282843805 cites W2168551259 @default.
• W4282843805 cites W2170776626 @default.
• W4282843805 cites W2212492613 @default.
• W4282843805 cites W2238223930 @default.
• W4282843805 cites W2269608764 @default.
• W4282843805 cites W2415296309 @default.
• W4282843805 cites W2437100796 @default.
• W4282843805 cites W2491813560 @default.
• W4282843805 cites W2581461126 @default.
• W4282843805 cites W2746586093 @default.
• W4282843805 cites W2762259514 @default.
• W4282843805 cites W2767586874 @default.
• W4282843805 cites W2789367247 @default.
• W4282843805 cites W2795012276 @default.
• W4282843805 cites W2888406753 @default.
• W4282843805 cites W2893597770 @default.
• W4282843805 cites W2905622537 @default.
• W4282843805 cites W2950938581 @default.
• W4282843805 cites W2966718046 @default.
• W4282843805 cites W2973009393 @default.
• W4282843805 cites W3009630500 @default.
• W4282843805 cites W3028360800 @default.
• W4282843805 cites W3032946988 @default.
• W4282843805 cites W3182728948 @default.
• W4282843805 cites W4249363934 @default.
• W4282843805 cites W4300952250 @default.
• W4282843805 cites W4313333717 @default.
• W4282843805 cites W4322701223 @default.
• W4282843805 cites W81905156 @default.

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