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• W4282913785 abstract "Peptide macrocycles (PMCs) are increasingly popular for the development of inhibitors of protein-protein interactions (PPIs). Large libraries of PMCs are accessible using display technologies like mRNA display and phage display. These technologies require macrocyclization chemistries to be compatible with biological milieu, severely limiting the types of technologies available for cyclization. Here, we introduce the novel non-canonical amino acid (ncAA) p-cyanoacetylene-L-Phe (pCAF), which facilitates spontaneous, co-translational cyclization through Michael addition with cysteine under physiological conditions. This new, robust chemistry creates stable macrocycles of a wide variety of ring sizes including bicyclic structures." @default.
• W4282913785 created "2022-06-16" @default.
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• W4282913785 date "2022-01-01" @default.
• W4282913785 modified "2023-09-30" @default.
• W4282913785 title "Spontaneous, co-translational peptide macrocyclization using <i>p</i>-cyanoacetylene–phenylalanine" @default.
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• W4282913785 doi "https://doi.org/10.1039/d2cc01148d" @default.
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