FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282914058> ?p ?o ?g. }

• W4282914058 endingPage "0" @default.
• W4282914058 startingPage "0" @default.
• W4282914058 abstract "The serum levels of sclerostin (SOST) are significant elevated in patients with pathological cardiac remodeling after myocardial infarction (MI). However, the mechanisms of SOST in cardiac remodeling remain largely uncharacterized.Collecting patients with MI who presented with or without left ventricular (LV) remodeling, we investigated differences in SOST expression. The influence of overexpression and silenced of SOST on the angiogenesis of cardiac microvascular endothelial cells (CMECs) was explored through in vitro experiments, and the impact of SOST on Wnt signaling marker proteins was examined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blot. Finally, we observed the effects of SOST on cardiac function and morphology in mice MI model, and verified the role of the Wnt signaling marker proteins in vivo.Serum SOST was significantly increased in patients with cardiac remodeling. Increased SOST expression was also observed in the infarcted hearts of C57BL/6 mice that underwent ligation of the left anterior descending branch of the coronary artery to induce MI. Furthermore, loss and gain of function experiments were conducted to investigate the role of SOST in post-infarct cardiac remodeling in vivo and in vitro. Overexpression of SOST promoted the proliferation and migration of cardiac fibroblasts (CFs), and inhibited angiogenesis of CMECs. In addition, overexpressing SOST in mice significantly deteriorated the post-infarct cardiac remodeling, as shown by the increased LV end systolic and end diastolic dimensions, decreased ejection fraction, and increased myocyte cross-section area and myocardial fibrosis. However, suppressing SOST expression showed the opposite results. The expression of Wnt signaling marker proteins was inhibited after overexpression of SOST, and enhanced after suppression of SOST in vivo and in vitro, suggesting involvement of the Wnt signaling pathway.The present study demonstrated that SOST aggravates post-infarct pathological myocardial remodeling by inhibiting angiogenesis of CMECs while promoting the proliferation of CFs, and this may be mediated by the Wnt signaling pathway. These results suggested that SOST might act as a biomarker to predict detrimental postinfarct cardiac remodeling, and may be a potential therapeutic target for the treatment of MI." @default.
• W4282914058 created "2022-06-16" @default.
• W4282914058 creator A5011454527 @default.
• W4282914058 creator A5025268609 @default.
• W4282914058 creator A5030164616 @default.
• W4282914058 creator A5051093347 @default.
• W4282914058 creator A5079392856 @default.
• W4282914058 date "2021-01-01" @default.
• W4282914058 modified "2023-10-17" @default.
• W4282914058 title "Sclerostin aggravates cardiac remodeling after myocardial infarction by inhibition of Wnt/β-catenin signaling pathway" @default.
• W4282914058 cites W1989722723 @default.
• W4282914058 cites W1997905284 @default.
• W4282914058 cites W2051521659 @default.
• W4282914058 cites W2062571649 @default.
• W4282914058 cites W2067879512 @default.
• W4282914058 cites W2087107619 @default.
• W4282914058 cites W2146886313 @default.
• W4282914058 cites W2345376732 @default.
• W4282914058 cites W2486123992 @default.
• W4282914058 cites W2510356781 @default.
• W4282914058 cites W2552127252 @default.
• W4282914058 cites W2609628869 @default.
• W4282914058 cites W2736222746 @default.
• W4282914058 cites W2737271199 @default.
• W4282914058 cites W2765124543 @default.
• W4282914058 cites W2768398928 @default.
• W4282914058 cites W2769015673 @default.
• W4282914058 cites W2790167195 @default.
• W4282914058 cites W2802072929 @default.
• W4282914058 cites W2803648072 @default.
• W4282914058 cites W2809634620 @default.
• W4282914058 cites W2888226842 @default.
• W4282914058 cites W2914919748 @default.
• W4282914058 cites W2960064396 @default.
• W4282914058 cites W2962747654 @default.
• W4282914058 cites W2966259311 @default.
• W4282914058 cites W2966657432 @default.
• W4282914058 cites W2985629397 @default.
• W4282914058 cites W2994043543 @default.
• W4282914058 cites W3033500181 @default.
• W4282914058 cites W3035249131 @default.
• W4282914058 cites W3042753181 @default.
• W4282914058 cites W3045084755 @default.
• W4282914058 cites W3045199214 @default.
• W4282914058 cites W3046249376 @default.
• W4282914058 cites W3047352808 @default.
• W4282914058 cites W3049560040 @default.
• W4282914058 cites W3090573230 @default.
• W4282914058 cites W3092321954 @default.
• W4282914058 cites W3092726210 @default.
• W4282914058 cites W3094303222 @default.
• W4282914058 cites W3139959853 @default.
• W4282914058 cites W3154686738 @default.
• W4282914058 cites W3184368135 @default.
• W4282914058 cites W3200984620 @default.
• W4282914058 cites W3202899407 @default.
• W4282914058 cites W3209465341 @default.
• W4282914058 cites W3210989208 @default.
• W4282914058 doi "https://doi.org/10.21037/jtd-22-473" @default.
• W4282914058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35693595" @default.
• W4282914058 hasPublicationYear "2021" @default.
• W4282914058 type Work @default.
• W4282914058 citedByCount "0" @default.
• W4282914058 crossrefType "journal-article" @default.
• W4282914058 hasAuthorship W4282914058A5011454527 @default.
• W4282914058 hasAuthorship W4282914058A5025268609 @default.
• W4282914058 hasAuthorship W4282914058A5030164616 @default.
• W4282914058 hasAuthorship W4282914058A5051093347 @default.
• W4282914058 hasAuthorship W4282914058A5079392856 @default.
• W4282914058 hasBestOaLocation W42829140581 @default.
• W4282914058 hasConcept C111566952 @default.
• W4282914058 hasConcept C126322002 @default.
• W4282914058 hasConcept C134018914 @default.
• W4282914058 hasConcept C137620995 @default.
• W4282914058 hasConcept C164705383 @default.
• W4282914058 hasConcept C2778198053 @default.
• W4282914058 hasConcept C2779277721 @default.
• W4282914058 hasConcept C2779537366 @default.
• W4282914058 hasConcept C2780394083 @default.
• W4282914058 hasConcept C500558357 @default.
• W4282914058 hasConcept C62478195 @default.
• W4282914058 hasConcept C71924100 @default.
• W4282914058 hasConcept C78085059 @default.
• W4282914058 hasConcept C86803240 @default.
• W4282914058 hasConcept C95444343 @default.
• W4282914058 hasConceptScore W4282914058C111566952 @default.
• W4282914058 hasConceptScore W4282914058C126322002 @default.
• W4282914058 hasConceptScore W4282914058C134018914 @default.
• W4282914058 hasConceptScore W4282914058C137620995 @default.
• W4282914058 hasConceptScore W4282914058C164705383 @default.
• W4282914058 hasConceptScore W4282914058C2778198053 @default.
• W4282914058 hasConceptScore W4282914058C2779277721 @default.
• W4282914058 hasConceptScore W4282914058C2779537366 @default.
• W4282914058 hasConceptScore W4282914058C2780394083 @default.
• W4282914058 hasConceptScore W4282914058C500558357 @default.
• W4282914058 hasConceptScore W4282914058C62478195 @default.
• W4282914058 hasConceptScore W4282914058C71924100 @default.
• W4282914058 hasConceptScore W4282914058C78085059 @default.

• next