Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282917406> ?p ?o ?g. }
- W4282917406 endingPage "4335" @default.
- W4282917406 startingPage "4322" @default.
- W4282917406 abstract "Regulatory T-cells (Treg) are essential to Tregs homeostasis and modulate the antitumor immune response in patients with lymphoma. However, the biology and prognostic impact of Tregs in splenic marginal zone lymphoma (SMZL) have not been studied.Biopsy specimens from 24 patients with SMZL and 12 reactive spleens (rSP) from individuals without lymphoma were analyzed by using CITE-seq (cellular indexing of transcriptomes and epitopes by sequencing), CyTOF (mass cytometry) analysis, and flow cytometry to explore the phenotype, transcriptomic profile, and clinical significance of intratumoral Tregs and their subsets. The biological characteristics and cell signaling pathways of intratumoral Treg subsets were confirmed by in vitro functional assays.We found that Tregs are more abundant in SMZL patients' spleens than rSP, and Tregs from patients with SMZL and rSP can be separated into CD161+Treg and CD26+Treg subsets. CD161+Tregs are increased in SMZL but have dysregulated immune function. We found that CD161+Treg and CD26+Tregs have unique gene expression and phenotypic profiles and are differentially correlated with patient outcomes. Specifically, increased CD161+Tregs are significantly associated with a favorable prognosis in patients with SMZL, whereas CD26+Tregs are associated with a poor prognosis. Furthermore, activation of the IL2/STAT5 pathway contributes to the induction of CD26+Tregs and can be reversed by STAT5 inhibition.IL2/STAT5-mediated expansion of CD26+Tregs contributes to a poor clinical outcome in SMZL and may represent a therapeutic opportunity in this disease." @default.
- W4282917406 created "2022-06-16" @default.
- W4282917406 creator A5002937504 @default.
- W4282917406 creator A5003407949 @default.
- W4282917406 creator A5012572537 @default.
- W4282917406 creator A5015161583 @default.
- W4282917406 creator A5031537463 @default.
- W4282917406 creator A5040160436 @default.
- W4282917406 creator A5046495281 @default.
- W4282917406 creator A5049816813 @default.
- W4282917406 creator A5051993273 @default.
- W4282917406 creator A5059729547 @default.
- W4282917406 creator A5063296982 @default.
- W4282917406 creator A5068796848 @default.
- W4282917406 creator A5082857859 @default.
- W4282917406 creator A5084324197 @default.
- W4282917406 date "2022-06-09" @default.
- W4282917406 modified "2023-09-25" @default.
- W4282917406 title "Phenotype, Function, and Clinical Significance of CD26+ and CD161+Tregs in Splenic Marginal Zone Lymphoma" @default.
- W4282917406 cites W1545137049 @default.
- W4282917406 cites W1981102729 @default.
- W4282917406 cites W2012426855 @default.
- W4282917406 cites W2024236749 @default.
- W4282917406 cites W2035618305 @default.
- W4282917406 cites W2042586707 @default.
- W4282917406 cites W2049426330 @default.
- W4282917406 cites W2049910239 @default.
- W4282917406 cites W2054745099 @default.
- W4282917406 cites W2060275053 @default.
- W4282917406 cites W2068089233 @default.
- W4282917406 cites W2076819781 @default.
- W4282917406 cites W2085257327 @default.
- W4282917406 cites W2091451666 @default.
- W4282917406 cites W2101794165 @default.
- W4282917406 cites W2106511606 @default.
- W4282917406 cites W2107665951 @default.
- W4282917406 cites W2115346550 @default.
- W4282917406 cites W2117692326 @default.
- W4282917406 cites W2119456915 @default.
- W4282917406 cites W2125616358 @default.
- W4282917406 cites W2128747434 @default.
- W4282917406 cites W2130410032 @default.
- W4282917406 cites W2158333823 @default.
- W4282917406 cites W2162413627 @default.
- W4282917406 cites W2166932789 @default.
- W4282917406 cites W2167556523 @default.
- W4282917406 cites W2171775292 @default.
- W4282917406 cites W2406296079 @default.
- W4282917406 cites W2475306716 @default.
- W4282917406 cites W2561926137 @default.
- W4282917406 cites W2572174216 @default.
- W4282917406 cites W2778965371 @default.
- W4282917406 cites W2795354071 @default.
- W4282917406 cites W2796582438 @default.
- W4282917406 cites W2798160602 @default.
- W4282917406 cites W2801309958 @default.
- W4282917406 cites W2897422388 @default.
- W4282917406 cites W2898609550 @default.
- W4282917406 cites W2909334052 @default.
- W4282917406 cites W2909885825 @default.
- W4282917406 cites W2917986195 @default.
- W4282917406 cites W2964407011 @default.
- W4282917406 cites W2982617740 @default.
- W4282917406 cites W3082441287 @default.
- W4282917406 cites W3164692211 @default.
- W4282917406 cites W3178580669 @default.
- W4282917406 cites W3181389722 @default.
- W4282917406 cites W3188798342 @default.
- W4282917406 cites W3205992773 @default.
- W4282917406 doi "https://doi.org/10.1158/1078-0432.ccr-22-0977" @default.
- W4282917406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35686915" @default.
- W4282917406 hasPublicationYear "2022" @default.
- W4282917406 type Work @default.
- W4282917406 citedByCount "2" @default.
- W4282917406 countsByYear W42829174062022 @default.
- W4282917406 countsByYear W42829174062023 @default.
- W4282917406 crossrefType "journal-article" @default.
- W4282917406 hasAuthorship W4282917406A5002937504 @default.
- W4282917406 hasAuthorship W4282917406A5003407949 @default.
- W4282917406 hasAuthorship W4282917406A5012572537 @default.
- W4282917406 hasAuthorship W4282917406A5015161583 @default.
- W4282917406 hasAuthorship W4282917406A5031537463 @default.
- W4282917406 hasAuthorship W4282917406A5040160436 @default.
- W4282917406 hasAuthorship W4282917406A5046495281 @default.
- W4282917406 hasAuthorship W4282917406A5049816813 @default.
- W4282917406 hasAuthorship W4282917406A5051993273 @default.
- W4282917406 hasAuthorship W4282917406A5059729547 @default.
- W4282917406 hasAuthorship W4282917406A5063296982 @default.
- W4282917406 hasAuthorship W4282917406A5068796848 @default.
- W4282917406 hasAuthorship W4282917406A5082857859 @default.
- W4282917406 hasAuthorship W4282917406A5084324197 @default.
- W4282917406 hasBestOaLocation W42829174062 @default.
- W4282917406 hasConcept C104317684 @default.
- W4282917406 hasConcept C127716648 @default.
- W4282917406 hasConcept C196166836 @default.
- W4282917406 hasConcept C203014093 @default.
- W4282917406 hasConcept C2776090121 @default.
- W4282917406 hasConcept C2776309230 @default.