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- W4282918487 abstract "Dihydrouridine is a modified nucleotide universally present in tRNAs, but the complete dihydrouridine landscape is unknown in any organism. We introduce dihydrouridine sequencing (D-seq) for transcriptome-wide mapping of D with single-nucleotide resolution and use it to uncover novel classes of dihydrouridine-containing RNA in yeast which include mRNA and small nucleolar RNA (snoRNA). The novel D sites are concentrated in conserved stem-loop regions consistent with a role for D in folding many functional RNA structures. We demonstrate dihydrouridine synthase (DUS)-dependent changes in splicing of a D-containing pre-mRNA in cells and show that D-modified mRNAs can be efficiently translated by eukaryotic ribosomes in vitro. This work establishes D as a new functional component of the mRNA epitranscriptome and paves the way for identifying the RNA targets of multiple DUS enzymes that are dysregulated in human disease." @default.
- W4282918487 created "2022-06-16" @default.
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- W4282918487 date "2022-05-24" @default.
- W4282918487 modified "2023-10-05" @default.
- W4282918487 title "Transcriptome-wide mapping reveals a diverse dihydrouridine landscape including mRNA" @default.
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- W4282918487 doi "https://doi.org/10.1371/journal.pbio.3001622" @default.
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