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- W4282918809 abstract "Five new 4-aza-2,3-didehydropodophyllotoxins were synthesized by a straightforward multi-component reaction in the hope of finding new structures with interesting anticancer activity. The “one-pot” synthesis process is developed to increase performance as well as minimize the steps involved. The obtained compounds with podophyllotoxin frame have the corresponding yields of 60-83%. Five new 4-aza-2,3-didehydropodophyllotoxins demonstrated comparable cytotoxicity against the Hep-G2, MCF7cell lines with an IC50 value of 52.2 - 261.2 µM with ellipsitine as the positive control." @default.
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- W4282918809 date "2022-03-23" @default.
- W4282918809 modified "2023-09-27" @default.
- W4282918809 title "Synthesis and cytotoxicity of new 4-aza-2,3-didehydropodophyllotoxins" @default.
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- W4282918809 doi "https://doi.org/10.15625/2525-2518/15577" @default.
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