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- W4282918976 abstract "Exposure to chronic adverse conditions, and the resultant activation of the neurobiological response cascade, has been associated with an increased risk of early onset of age-related disease and, recently, with an older biological age. This body of research has led to the hypothesis that exposure to stressful life experiences, when occurring repeatedly or over a prolonged period, may accelerate the rate at which the body ages. The mechanisms through which chronic psychosocial stress influences distinct biological aging pathways to alter rates of aging likely involve multiple layers in the physiological-molecular network. In this review, we integrate research using animal, human, and in vitro models to begin to delineate the distinct pathways through which chronic psychosocial stress may impact biological aging, as well as the neuroendocrine mediators (i.e., norepinephrine, epinephrine, and glucocorticoids) that may drive these effects. Findings highlight key connections between stress and aging, namely cellular metabolic activity, DNA damage, telomere length, cellular senescence, and inflammatory response patterns. We conclude with a guiding framework and conceptual model that outlines the most promising biological pathways by which chronic adverse conditions could accelerate aging and point to key missing gaps in knowledge where future research could best answer these pressing questions." @default.
- W4282918976 created "2022-06-16" @default.
- W4282918976 creator A5012844880 @default.
- W4282918976 creator A5015330183 @default.
- W4282918976 creator A5076610411 @default.
- W4282918976 date "2022-08-01" @default.
- W4282918976 modified "2023-10-17" @default.
- W4282918976 title "Stress-induced biological aging: A review and guide for research priorities" @default.
- W4282918976 cites W1520207918 @default.
- W4282918976 cites W1520948059 @default.
- W4282918976 cites W153393150 @default.
- W4282918976 cites W1579661837 @default.
- W4282918976 cites W1878109538 @default.
- W4282918976 cites W1898081212 @default.
- W4282918976 cites W1964888378 @default.
- W4282918976 cites W1965707131 @default.
- W4282918976 cites W1968698737 @default.
- W4282918976 cites W1970924670 @default.
- W4282918976 cites W1974047233 @default.
- W4282918976 cites W1974323299 @default.
- W4282918976 cites W1977570615 @default.
- W4282918976 cites W1978794619 @default.
- W4282918976 cites W1980878904 @default.
- W4282918976 cites W1980944102 @default.
- W4282918976 cites W1983594275 @default.
- W4282918976 cites W1985382600 @default.
- W4282918976 cites W1986998491 @default.
- W4282918976 cites W1989896761 @default.
- W4282918976 cites W1989978497 @default.
- W4282918976 cites W1996411223 @default.
- W4282918976 cites W1996891599 @default.
- W4282918976 cites W1996982207 @default.
- W4282918976 cites W1998448545 @default.
- W4282918976 cites W1999872096 @default.
- W4282918976 cites W2004314923 @default.
- W4282918976 cites W2006980012 @default.
- W4282918976 cites W2008034840 @default.
- W4282918976 cites W2008246214 @default.
- W4282918976 cites W2011617932 @default.
- W4282918976 cites W2012636104 @default.
- W4282918976 cites W2014566626 @default.
- W4282918976 cites W2015758233 @default.
- W4282918976 cites W2023957242 @default.
- W4282918976 cites W2024209230 @default.
- W4282918976 cites W2025607005 @default.
- W4282918976 cites W2030548258 @default.
- W4282918976 cites W2032667530 @default.
- W4282918976 cites W2034621596 @default.
- W4282918976 cites W2045928883 @default.
- W4282918976 cites W2049814665 @default.
- W4282918976 cites W2049971585 @default.
- W4282918976 cites W2050192604 @default.
- W4282918976 cites W2051251958 @default.
- W4282918976 cites W2051369986 @default.
- W4282918976 cites W2051875300 @default.
- W4282918976 cites W2052050098 @default.
- W4282918976 cites W2056327604 @default.
- W4282918976 cites W2056550977 @default.
- W4282918976 cites W2057600997 @default.
- W4282918976 cites W2058197513 @default.
- W4282918976 cites W2060845496 @default.
- W4282918976 cites W2066906062 @default.
- W4282918976 cites W2069396003 @default.
- W4282918976 cites W2072431132 @default.
- W4282918976 cites W2072479238 @default.
- W4282918976 cites W2072533343 @default.
- W4282918976 cites W2072628425 @default.
- W4282918976 cites W2077450385 @default.
- W4282918976 cites W2078619626 @default.
- W4282918976 cites W2080763798 @default.
- W4282918976 cites W2081823959 @default.
- W4282918976 cites W2082258383 @default.
- W4282918976 cites W2090653741 @default.
- W4282918976 cites W2091467934 @default.
- W4282918976 cites W2097529540 @default.
- W4282918976 cites W2099390922 @default.
- W4282918976 cites W2101037767 @default.
- W4282918976 cites W2105012632 @default.
- W4282918976 cites W2115852450 @default.
- W4282918976 cites W2122740168 @default.
- W4282918976 cites W2124098526 @default.
- W4282918976 cites W2125978064 @default.
- W4282918976 cites W2126104386 @default.
- W4282918976 cites W2126525177 @default.
- W4282918976 cites W2126795224 @default.
- W4282918976 cites W2129155846 @default.
- W4282918976 cites W2129976097 @default.
- W4282918976 cites W2130198046 @default.
- W4282918976 cites W2130958461 @default.
- W4282918976 cites W2133353372 @default.
- W4282918976 cites W2138742393 @default.
- W4282918976 cites W2139463883 @default.
- W4282918976 cites W2139808613 @default.
- W4282918976 cites W2140711005 @default.
- W4282918976 cites W2142170111 @default.
- W4282918976 cites W2144101679 @default.
- W4282918976 cites W2145200068 @default.
- W4282918976 cites W2151454086 @default.