Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282920935> ?p ?o ?g. }
- W4282920935 endingPage "867" @default.
- W4282920935 startingPage "867" @default.
- W4282920935 abstract "Liver fibrosis is a sign of non-alcoholic fatty liver disease progression towards steatohepatitis (NASH) and cirrhosis and is accelerated by aging. Glutaredoxin-1 (Glrx) controls redox signaling by reversing protein S-glutathionylation, induced by oxidative stress, and its deletion causes fatty liver in mice. Although Glrx regulates various pathways, including metabolism and apoptosis, the impact of Glrx on liver fibrosis has not been studied. Therefore, we evaluated the role of Glrx in liver fibrosis induced by aging or by a high-fat, high-fructose diet. We found that: (1) upregulation of Glrx expression level inhibits age-induced hepatic apoptosis and liver fibrosis. In vitro studies indicate that Glrx regulates Fas-induced apoptosis in hepatocytes; (2) diet-induced NASH leads to reduced expression of Glrx and higher levels of S-glutathionylated proteins in the liver. In the NASH model, hepatocyte-specific adeno-associated virus-mediated Glrx overexpression (AAV-Hep-Glrx) suppresses fibrosis and apoptosis and improves liver function; (3) AAV-Hep-Glrx significantly inhibits transcription of Zbtb16 and negatively regulates immune pathways in the NASH liver. In conclusion, the upregulation of Glrx is a potential therapeutic for the reversal of NASH progression by attenuating inflammatory and fibrotic processes." @default.
- W4282920935 created "2022-06-16" @default.
- W4282920935 creator A5006011878 @default.
- W4282920935 creator A5016999311 @default.
- W4282920935 creator A5019087018 @default.
- W4282920935 creator A5050433160 @default.
- W4282920935 creator A5050442755 @default.
- W4282920935 creator A5063553486 @default.
- W4282920935 creator A5091347941 @default.
- W4282920935 date "2022-04-28" @default.
- W4282920935 modified "2023-10-15" @default.
- W4282920935 title "Administration of Glutaredoxin-1 Attenuates Liver Fibrosis Caused by Aging and Non-Alcoholic Steatohepatitis" @default.
- W4282920935 cites W1522814938 @default.
- W4282920935 cites W1964572117 @default.
- W4282920935 cites W1968396962 @default.
- W4282920935 cites W1970950555 @default.
- W4282920935 cites W1973039753 @default.
- W4282920935 cites W1981419458 @default.
- W4282920935 cites W1990929380 @default.
- W4282920935 cites W1999331588 @default.
- W4282920935 cites W2008118006 @default.
- W4282920935 cites W2011768800 @default.
- W4282920935 cites W2014718725 @default.
- W4282920935 cites W2026335686 @default.
- W4282920935 cites W2031457189 @default.
- W4282920935 cites W2034188379 @default.
- W4282920935 cites W2039540104 @default.
- W4282920935 cites W2041911908 @default.
- W4282920935 cites W2044918639 @default.
- W4282920935 cites W2062812115 @default.
- W4282920935 cites W2063437798 @default.
- W4282920935 cites W2066308932 @default.
- W4282920935 cites W2068864715 @default.
- W4282920935 cites W2075359233 @default.
- W4282920935 cites W2087389370 @default.
- W4282920935 cites W2093637273 @default.
- W4282920935 cites W2107943478 @default.
- W4282920935 cites W2110962551 @default.
- W4282920935 cites W2111951337 @default.
- W4282920935 cites W2130410032 @default.
- W4282920935 cites W2135827569 @default.
- W4282920935 cites W2162382402 @default.
- W4282920935 cites W2166902551 @default.
- W4282920935 cites W2170989872 @default.
- W4282920935 cites W2171753559 @default.
- W4282920935 cites W2204688218 @default.
- W4282920935 cites W2205019274 @default.
- W4282920935 cites W2516581072 @default.
- W4282920935 cites W2560848451 @default.
- W4282920935 cites W2561069382 @default.
- W4282920935 cites W2613030341 @default.
- W4282920935 cites W2743667261 @default.
- W4282920935 cites W2765883724 @default.
- W4282920935 cites W2787406891 @default.
- W4282920935 cites W2795885266 @default.
- W4282920935 cites W2818331228 @default.
- W4282920935 cites W2871400816 @default.
- W4282920935 cites W2897407482 @default.
- W4282920935 cites W2947304419 @default.
- W4282920935 cites W2952411693 @default.
- W4282920935 cites W2966241365 @default.
- W4282920935 cites W2966547141 @default.
- W4282920935 cites W2971782246 @default.
- W4282920935 cites W2973390883 @default.
- W4282920935 cites W2979641493 @default.
- W4282920935 cites W3010365138 @default.
- W4282920935 cites W3159265081 @default.
- W4282920935 doi "https://doi.org/10.3390/antiox11050867" @default.
- W4282920935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35624731" @default.
- W4282920935 hasPublicationYear "2022" @default.
- W4282920935 type Work @default.
- W4282920935 citedByCount "4" @default.
- W4282920935 countsByYear W42829209352022 @default.
- W4282920935 countsByYear W42829209352023 @default.
- W4282920935 crossrefType "journal-article" @default.
- W4282920935 hasAuthorship W4282920935A5006011878 @default.
- W4282920935 hasAuthorship W4282920935A5016999311 @default.
- W4282920935 hasAuthorship W4282920935A5019087018 @default.
- W4282920935 hasAuthorship W4282920935A5050433160 @default.
- W4282920935 hasAuthorship W4282920935A5050442755 @default.
- W4282920935 hasAuthorship W4282920935A5063553486 @default.
- W4282920935 hasAuthorship W4282920935A5091347941 @default.
- W4282920935 hasBestOaLocation W42829209351 @default.
- W4282920935 hasConcept C104317684 @default.
- W4282920935 hasConcept C125619963 @default.
- W4282920935 hasConcept C127561419 @default.
- W4282920935 hasConcept C142724271 @default.
- W4282920935 hasConcept C190283241 @default.
- W4282920935 hasConcept C2776151105 @default.
- W4282920935 hasConcept C2778772119 @default.
- W4282920935 hasConcept C2779134260 @default.
- W4282920935 hasConcept C2779478299 @default.
- W4282920935 hasConcept C2780559512 @default.
- W4282920935 hasConcept C3623737 @default.
- W4282920935 hasConcept C502942594 @default.
- W4282920935 hasConcept C55493867 @default.
- W4282920935 hasConcept C71924100 @default.
- W4282920935 hasConcept C86803240 @default.