FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282921000> ?p ?o ?g. }

• W4282921000 endingPage "735" @default.
• W4282921000 startingPage "726" @default.
• W4282921000 abstract "Myricitrin (MYR), a flavonol consumed in the leaves and fruits of plants of the Myrtaceae family, presents anti-proliferative, anti-inflammatory, anti-diabetic, and antioxidant properties in humans. However, there are few studies regarding the cyto-genotoxicity and the chemopreventive potential of MYR. Using the in vitro Micronucleus test, the cytostasis, mutagenicity, and modulatory effect of MYR in CHO-K1 cells were assessed. The concentrations of 39 and 78 µg/mL (p < 0.001.) of MYR decrease the cytokinesis-block proliferation index (CBPI) in the short exposure treatment (4 h), while in the extended treatment (24 h), concentrations of 4.8, 9.7, 19.5, 39 and 78 µg/mL (p < 0.001.) decreased the CBPI. MYR associated with oxaliplatin decreased CBPI at all tested concentrations in the pre-(p < 0.001) and post-treatments (p < 0.001), but there was no decrease when associated with bleomycin. As for chromosome instability, MYR did not increase the frequency of micronuclei (MNi), nucleoplasmic bridges (NPBs), or nuclear buds (NBUDs) in the 4 h exposure time, however, in the 24 h treatment, MYR increased the frequency of MNi and NPBs at concentration 19.5 µg/mL (p < 0.001). As for the modulatory effect, MYR associated with bleomycin decreased the frequency of MNi, NPBs, and NBUDs at all concentrations in the pretreatment (MNi and NPBs p < 0.001, NBUDs p < 0.05) and simultaneously (MNi, NPBs and NBUDs p < 0.001). When associated with oxaliplatin, the simultaneous treatment decreased the frequency of MNi (p < 0.001) and NBUDs (p < 0.01) at all concentrations, however, in the post-treatment, MYR increased MNi (p < 0.001) and NPBs p < 0.05) in CHO-K1 cells, when compared to oxaliplatin alone. The results demonstrated that MYR could modulate the mutagenic and cytostatic actions of bleomycin and oxaliplatin, demonstrating distinct behaviors, depending on the mechanism of action of the chemotherapeutic agent." @default.
• W4282921000 created "2022-06-16" @default.
• W4282921000 creator A5005762826 @default.
• W4282921000 creator A5011744294 @default.
• W4282921000 creator A5033095333 @default.
• W4282921000 creator A5054804236 @default.
• W4282921000 creator A5081831719 @default.
• W4282921000 creator A5090217201 @default.
• W4282921000 date "2022-06-14" @default.
• W4282921000 modified "2023-10-02" @default.
• W4282921000 title "Modulatory effect of myricitrin against chromosome instability and cytostasis induced by bleomycin and oxaliplatin in CHO-K1 cells" @default.
• W4282921000 cites W1579817961 @default.
• W4282921000 cites W1756169569 @default.
• W4282921000 cites W1794813415 @default.
• W4282921000 cites W1965093545 @default.
• W4282921000 cites W1970252313 @default.
• W4282921000 cites W1970564305 @default.
• W4282921000 cites W1976179991 @default.
• W4282921000 cites W1979189704 @default.
• W4282921000 cites W1979336714 @default.
• W4282921000 cites W1990169758 @default.
• W4282921000 cites W1996554329 @default.
• W4282921000 cites W1999535022 @default.
• W4282921000 cites W2008685099 @default.
• W4282921000 cites W2027930950 @default.
• W4282921000 cites W2029704109 @default.
• W4282921000 cites W2036052021 @default.
• W4282921000 cites W2064136305 @default.
• W4282921000 cites W2064995015 @default.
• W4282921000 cites W2081291560 @default.
• W4282921000 cites W2092130692 @default.
• W4282921000 cites W2098376613 @default.
• W4282921000 cites W2105908798 @default.
• W4282921000 cites W2112784018 @default.
• W4282921000 cites W2158602227 @default.
• W4282921000 cites W2274566726 @default.
• W4282921000 cites W2393656963 @default.
• W4282921000 cites W2554091882 @default.
• W4282921000 cites W2588405611 @default.
• W4282921000 cites W2765500342 @default.
• W4282921000 cites W2767098513 @default.
• W4282921000 cites W2794192359 @default.
• W4282921000 cites W2796609642 @default.
• W4282921000 cites W2801140244 @default.
• W4282921000 cites W2902042937 @default.
• W4282921000 cites W2911443382 @default.
• W4282921000 cites W2917226020 @default.
• W4282921000 cites W2944991494 @default.
• W4282921000 cites W2948372818 @default.
• W4282921000 cites W2949556875 @default.
• W4282921000 cites W2982332742 @default.
• W4282921000 cites W2993258893 @default.
• W4282921000 cites W2995292489 @default.
• W4282921000 cites W2996124523 @default.
• W4282921000 cites W2997699426 @default.
• W4282921000 cites W3045924649 @default.
• W4282921000 cites W3096521890 @default.
• W4282921000 cites W783831555 @default.
• W4282921000 doi "https://doi.org/10.1080/01480545.2022.2085739" @default.
• W4282921000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35702048" @default.
• W4282921000 hasPublicationYear "2022" @default.
• W4282921000 type Work @default.
• W4282921000 citedByCount "3" @default.
• W4282921000 countsByYear W42829210002022 @default.
• W4282921000 countsByYear W42829210002023 @default.
• W4282921000 crossrefType "journal-article" @default.
• W4282921000 hasAuthorship W4282921000A5005762826 @default.
• W4282921000 hasAuthorship W4282921000A5011744294 @default.
• W4282921000 hasAuthorship W4282921000A5033095333 @default.
• W4282921000 hasAuthorship W4282921000A5054804236 @default.
• W4282921000 hasAuthorship W4282921000A5081831719 @default.
• W4282921000 hasAuthorship W4282921000A5090217201 @default.
• W4282921000 hasConcept C104317684 @default.
• W4282921000 hasConcept C109316439 @default.
• W4282921000 hasConcept C141231307 @default.
• W4282921000 hasConcept C178790620 @default.
• W4282921000 hasConcept C182547069 @default.
• W4282921000 hasConcept C185592680 @default.
• W4282921000 hasConcept C202751555 @default.
• W4282921000 hasConcept C24389824 @default.
• W4282921000 hasConcept C2777263532 @default.
• W4282921000 hasConcept C2778004101 @default.
• W4282921000 hasConcept C2778959862 @default.
• W4282921000 hasConcept C2779054382 @default.
• W4282921000 hasConcept C29730261 @default.
• W4282921000 hasConcept C36681516 @default.
• W4282921000 hasConcept C45080847 @default.
• W4282921000 hasConcept C55493867 @default.
• W4282921000 hasConcept C86803240 @default.
• W4282921000 hasConcept C98274493 @default.
• W4282921000 hasConceptScore W4282921000C104317684 @default.
• W4282921000 hasConceptScore W4282921000C109316439 @default.
• W4282921000 hasConceptScore W4282921000C141231307 @default.
• W4282921000 hasConceptScore W4282921000C178790620 @default.
• W4282921000 hasConceptScore W4282921000C182547069 @default.
• W4282921000 hasConceptScore W4282921000C185592680 @default.
• W4282921000 hasConceptScore W4282921000C202751555 @default.
• W4282921000 hasConceptScore W4282921000C24389824 @default.

• next