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- W4282922005 abstract "To identify molecular predictors of grade 3/4 neutropenic or leukopenic events (NLE) after chemotherapy using a genome-wide association study (GWAS).A GWAS was performed on patients in the phase III chemotherapy study SUCCESS-A (n = 3,322). Genotyping was done using the Illumina HumanOmniExpress-12v1 array. Findings were functionally validated with cell culture models and the genotypes and gene expression of possible causative genes were correlated with clinical treatment response and prognostic outcomes.One locus on chromosome 16 (rs4784750; NLRC5; P = 1.56E-8) and another locus on chromosome 13 (rs16972207; TNFSF13B; P = 3.42E-8) were identified at a genome-wide significance level. Functional validation revealed that expression of these two genes is altered by genotype-dependent and chemotherapy-dependent activity of two transcription factors. Genotypes also showed an association with disease-free survival in patients with an NLE.Two loci in NLRC5 and TNFSF13B are associated with NLEs. The involvement of the MHC I regulator NLRC5 implies the possible involvement of immuno-oncological pathways." @default.
- W4282922005 created "2022-06-16" @default.
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- W4282922005 date "2022-06-02" @default.
- W4282922005 modified "2023-10-12" @default.
- W4282922005 title "Identification of Two Genetic Loci Associated with Leukopenia after Chemotherapy in Patients with Breast Cancer" @default.
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- W4282922005 doi "https://doi.org/10.1158/1078-0432.ccr-20-4774" @default.
- W4282922005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35653140" @default.
- W4282922005 hasPublicationYear "2022" @default.
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