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- W4282922208 abstract "Human serum albumin (HSA) can bind with numerous drugs, leading to a significant influence on drug pharmacokinetics as well as undesirable drug-drug interactions due to competitive binding. Probing the HSA drug binding site thus offers great opportunities to reveal drug-HSA binding profiles. In the present study, a fluorescent probe (E)-4-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)vinyl)-1-propylpyridin-1-ium (TTPy) has been prepared, which exhibits enhancement of deep-red to near-infrared (NIR) fluorescence upon HSA binding. The competitive binding assay indicated that TTPy can target the HSA binding site of fenamates, a group of non-steroidal anti-inflammatory drugs (NSAIDs), with moderate binding affinity (1.95 × 106 M-1 at 303 K). More interestingly, TTPy enables fluorescent labeling of HSA upon visible light irradiation. This study provides promising ways for HSA drug binding site identification and photochemical protein labeling." @default.
- W4282922208 created "2022-06-16" @default.
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- W4282922208 date "2022-01-01" @default.
- W4282922208 modified "2023-10-10" @default.
- W4282922208 title "Probing the serum albumin binding site of fenamates and photochemical protein labeling with a fluorescent dye" @default.
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- W4282922208 doi "https://doi.org/10.1039/d2ob00717g" @default.
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