Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282922275> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4282922275 endingPage "759" @default.
- W4282922275 startingPage "755" @default.
- W4282922275 abstract "To investigate the characteristics of gene mutation in elderly patients with acute myeloid leukemia (AML) and its effect on prognosis.The clinical and laboratorial characteristics of 54 AML patients (≥60 years old) in Department of Hematology, Tangdu Hospital were analyzed retrospectively during April 2016 to October 2019. Thirty-four AML/myelodysplastic syndrome/myeloproliferative neoplasm related mutant genes were detected by second-generation sequencing technology, and their clinical characteristics, treatment effect, and influence on prognosis were analyzed.All the patients received DAC+CAG induction treatment, after 1-2 couses of treatment, 36 cases (66.7%) achieved complete response, with a total effective rate of 75.9%, and the median survival time was 17 months. The most frequent mutant genes were TET2 (33.3%), CEBPA (31.5%), DNMT3A (18.5%), ASXL1 (16.7%), NRAS (14.8%), RUNX1 (14.8%), FLT3-ITD (12.9%), TP53 (12.9%), NPM1 (12.9%), and IDH2 (12.9%). Among 7 patients with TP53 mutation, 6 cases obtained complete response after 1-2 courses of induction treatment, but there was no statistically significant difference in the effect on prognosis. Patients with FLT3-ITD and NRAS mutations had shorter overall survival time compared with who had no mutation (P=0.47, P=0.48). Multivariate analysis showed that FLT3-ITD and NRAS mutations were poor prognostic factors.The incidence of TET2 gene mutation is high in elderly AML patients. AML patients with TET2 and TP53 mutations may benefit from Decitabine-based chemotherapy. However, patients with FLT3-ITD and NRAS mutations have a short survival time, and may have a poor prognosis.老年急性髓系白血病患者的基因突变特征及预后分析.探讨老年急性髓系白血病患者的基因突变特征及对预后的影响.回顾性分析2016年4月至2019年10月在空军军医大学唐都医院血液科接受治疗的54例年龄≥60岁初治急性髓系白血病患者的临床资料，采用二代测序技术检测34个急性髓系白血病/骨髓增生异常综合征/骨髓增殖性肿瘤相关突变基因，分析其临床特征、治疗效果及对预后的影响.54例患者均采用DAC+CAG方案诱导治疗，经过1-2个疗程治疗达完全缓解者36例（66.7%），总有效率75.9%，中位生存时间为17个月。突变频率较高的基因依次为TET2（33.3%）、CEBPA（31.5%）、DNMT3A （18.5%）、ASXL1（16.7%）、NRAS（14.8%）、RUNX1（14.8%）、FLT3-ITD（12.9%）、TP53（12.9%）、NPM1（12.9%）、 IDH2（12.9%）。7例伴TP53突变的患者中6例经1-2个疗程诱导治疗获得完全缓解，但对预后的影响无统计学差异。伴FLT3-ITD和NRAS基因突变患者的总生存时间均短于无突变的患者（P=0.47，P=0.48）。多因素分析显示，FLT3-ITD及NRAS基因突变是预后不良因素.老年急性髓系白血病患者TET2基因突变发生率高。伴TET2和TP53基因突变的老年急性髓系白血病患者可从地西他滨中获益，而伴FLT3-ITD、NRAS基因突变的患者生存时间短，可能预后不良." @default.
- W4282922275 created "2022-06-16" @default.
- W4282922275 creator A5009590736 @default.
- W4282922275 creator A5012061654 @default.
- W4282922275 creator A5012842083 @default.
- W4282922275 creator A5013178268 @default.
- W4282922275 creator A5031138415 @default.
- W4282922275 creator A5054977676 @default.
- W4282922275 creator A5063481044 @default.
- W4282922275 date "2022-06-01" @default.
- W4282922275 modified "2023-09-26" @default.
- W4282922275 title "[Analysis of Gene Mutation Characteristics and Prognosis of Elderly Patients with Acute Myeloid Leukemia]." @default.
- W4282922275 doi "https://doi.org/10.19746/j.cnki.issn.1009-2137.2022.03.015" @default.
- W4282922275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35680801" @default.
- W4282922275 hasPublicationYear "2022" @default.
- W4282922275 type Work @default.
- W4282922275 citedByCount "0" @default.
- W4282922275 crossrefType "journal-article" @default.
- W4282922275 hasAuthorship W4282922275A5009590736 @default.
- W4282922275 hasAuthorship W4282922275A5012061654 @default.
- W4282922275 hasAuthorship W4282922275A5012842083 @default.
- W4282922275 hasAuthorship W4282922275A5013178268 @default.
- W4282922275 hasAuthorship W4282922275A5031138415 @default.
- W4282922275 hasAuthorship W4282922275A5054977676 @default.
- W4282922275 hasAuthorship W4282922275A5063481044 @default.
- W4282922275 hasConcept C104317684 @default.
- W4282922275 hasConcept C121608353 @default.
- W4282922275 hasConcept C126322002 @default.
- W4282922275 hasConcept C143998085 @default.
- W4282922275 hasConcept C150194340 @default.
- W4282922275 hasConcept C190727270 @default.
- W4282922275 hasConcept C21790070 @default.
- W4282922275 hasConcept C2483381 @default.
- W4282922275 hasConcept C2776611710 @default.
- W4282922275 hasConcept C2776694085 @default.
- W4282922275 hasConcept C2778729363 @default.
- W4282922275 hasConcept C2780235182 @default.
- W4282922275 hasConcept C2781187634 @default.
- W4282922275 hasConcept C2910954276 @default.
- W4282922275 hasConcept C2994225774 @default.
- W4282922275 hasConcept C30481170 @default.
- W4282922275 hasConcept C45091340 @default.
- W4282922275 hasConcept C501734568 @default.
- W4282922275 hasConcept C526805850 @default.
- W4282922275 hasConcept C53226629 @default.
- W4282922275 hasConcept C54355233 @default.
- W4282922275 hasConcept C71924100 @default.
- W4282922275 hasConcept C86803240 @default.
- W4282922275 hasConcept C90924648 @default.
- W4282922275 hasConceptScore W4282922275C104317684 @default.
- W4282922275 hasConceptScore W4282922275C121608353 @default.
- W4282922275 hasConceptScore W4282922275C126322002 @default.
- W4282922275 hasConceptScore W4282922275C143998085 @default.
- W4282922275 hasConceptScore W4282922275C150194340 @default.
- W4282922275 hasConceptScore W4282922275C190727270 @default.
- W4282922275 hasConceptScore W4282922275C21790070 @default.
- W4282922275 hasConceptScore W4282922275C2483381 @default.
- W4282922275 hasConceptScore W4282922275C2776611710 @default.
- W4282922275 hasConceptScore W4282922275C2776694085 @default.
- W4282922275 hasConceptScore W4282922275C2778729363 @default.
- W4282922275 hasConceptScore W4282922275C2780235182 @default.
- W4282922275 hasConceptScore W4282922275C2781187634 @default.
- W4282922275 hasConceptScore W4282922275C2910954276 @default.
- W4282922275 hasConceptScore W4282922275C2994225774 @default.
- W4282922275 hasConceptScore W4282922275C30481170 @default.
- W4282922275 hasConceptScore W4282922275C45091340 @default.
- W4282922275 hasConceptScore W4282922275C501734568 @default.
- W4282922275 hasConceptScore W4282922275C526805850 @default.
- W4282922275 hasConceptScore W4282922275C53226629 @default.
- W4282922275 hasConceptScore W4282922275C54355233 @default.
- W4282922275 hasConceptScore W4282922275C71924100 @default.
- W4282922275 hasConceptScore W4282922275C86803240 @default.
- W4282922275 hasConceptScore W4282922275C90924648 @default.
- W4282922275 hasIssue "3" @default.
- W4282922275 hasLocation W42829222751 @default.
- W4282922275 hasOpenAccess W4282922275 @default.
- W4282922275 hasPrimaryLocation W42829222751 @default.
- W4282922275 hasRelatedWork W10263580 @default.
- W4282922275 hasRelatedWork W13496784 @default.
- W4282922275 hasRelatedWork W1605945 @default.
- W4282922275 hasRelatedWork W16233543 @default.
- W4282922275 hasRelatedWork W16783332 @default.
- W4282922275 hasRelatedWork W19219843 @default.
- W4282922275 hasRelatedWork W20411174 @default.
- W4282922275 hasRelatedWork W4474461 @default.
- W4282922275 hasRelatedWork W6398642 @default.
- W4282922275 hasRelatedWork W9144962 @default.
- W4282922275 hasVolume "30" @default.
- W4282922275 isParatext "false" @default.
- W4282922275 isRetracted "false" @default.
- W4282922275 workType "article" @default.