Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282922900> ?p ?o ?g. }
- W4282922900 endingPage "2223" @default.
- W4282922900 startingPage "2190" @default.
- W4282922900 abstract "Since the 1930s, fixed bed reactors (FBR) have been operated for continuous hydrogenation reactions in the petrochemical/fine chemical industries, with publications each year detailing engineering principles, scientific breakthroughs, equipment design and setup, from these industries. Only in the last two decades, FBR have started to be utilized in the pharmaceutical industry as a result of sustainability commitment and growing demand of complex and specialized drugs. Most of the engineering knowledge is transferable across industries; however, there are differentiators inherent to each industry, with the pharmaceutical industry having its own unique challenges. One of the main differentiators between industries is the reactor scale and, consequently, reactor catalyst requirements. Petrochemicals or fine chemicals operate on a large industrial scale, with up to 72 m high reactors, with an internal diameter on the order of 5 m (China Petroleum & Chemical Corporation), and require large volumes of catalysts because of the high product demand for thousands of tonnes per year, while for the pharmaceutical industry, a smaller scale reactor is required for product demand in the thousands of kilograms per year range. It is the reactor size that defines catalyst specifications, such as particle size and geometry. Many transformations have emerged from academic and medicinal chemistry groups utilizing the ThalesNano H-Cube; however, there are relatively few reported processes that have been scaled within the pharmaceutical industry. This Perspective outlines a review of continuous flow hydrogenation technologies; focusing on the trickle bed reactor (TBR) and the respective process operation and effect of process variables on reaction rate requirements for the pharmaceutical industry; it also reflects on transformation examples using TBR across the pharmaceutical industry." @default.
- W4282922900 created "2022-06-16" @default.
- W4282922900 creator A5020862367 @default.
- W4282922900 creator A5033626048 @default.
- W4282922900 creator A5066903616 @default.
- W4282922900 creator A5081093844 @default.
- W4282922900 date "2022-06-14" @default.
- W4282922900 modified "2023-10-16" @default.
- W4282922900 title "Fixed Bed Continuous Hydrogenations in Trickle Flow Mode: A Pharmaceutical Industry Perspective" @default.
- W4282922900 cites W1023611071 @default.
- W4282922900 cites W1480859926 @default.
- W4282922900 cites W1493869471 @default.
- W4282922900 cites W1578712387 @default.
- W4282922900 cites W1633875241 @default.
- W4282922900 cites W1762962726 @default.
- W4282922900 cites W1865411423 @default.
- W4282922900 cites W1874400403 @default.
- W4282922900 cites W1920817682 @default.
- W4282922900 cites W1945008858 @default.
- W4282922900 cites W1963768557 @default.
- W4282922900 cites W1969356069 @default.
- W4282922900 cites W1969532196 @default.
- W4282922900 cites W1969596864 @default.
- W4282922900 cites W1971981964 @default.
- W4282922900 cites W1974014903 @default.
- W4282922900 cites W1974395014 @default.
- W4282922900 cites W1974969209 @default.
- W4282922900 cites W1982922021 @default.
- W4282922900 cites W1983145511 @default.
- W4282922900 cites W1984332952 @default.
- W4282922900 cites W1985480092 @default.
- W4282922900 cites W1985987205 @default.
- W4282922900 cites W1986998633 @default.
- W4282922900 cites W1989502014 @default.
- W4282922900 cites W1992071410 @default.
- W4282922900 cites W1994536524 @default.
- W4282922900 cites W1997827125 @default.
- W4282922900 cites W2001761132 @default.
- W4282922900 cites W2001931140 @default.
- W4282922900 cites W2003460230 @default.
- W4282922900 cites W2003609959 @default.
- W4282922900 cites W2004278157 @default.
- W4282922900 cites W2005440005 @default.
- W4282922900 cites W2008092544 @default.
- W4282922900 cites W2008842857 @default.
- W4282922900 cites W2009063895 @default.
- W4282922900 cites W2014350576 @default.
- W4282922900 cites W2014628923 @default.
- W4282922900 cites W2014995650 @default.
- W4282922900 cites W2015276699 @default.
- W4282922900 cites W2016424453 @default.
- W4282922900 cites W2018844768 @default.
- W4282922900 cites W2021133089 @default.
- W4282922900 cites W2022335492 @default.
- W4282922900 cites W2023959054 @default.
- W4282922900 cites W2025551065 @default.
- W4282922900 cites W2025553351 @default.
- W4282922900 cites W2026519604 @default.
- W4282922900 cites W2028955846 @default.
- W4282922900 cites W2032875430 @default.
- W4282922900 cites W2034204773 @default.
- W4282922900 cites W2035689881 @default.
- W4282922900 cites W2043899406 @default.
- W4282922900 cites W2050370389 @default.
- W4282922900 cites W2051511478 @default.
- W4282922900 cites W2053708042 @default.
- W4282922900 cites W2055884449 @default.
- W4282922900 cites W2059701502 @default.
- W4282922900 cites W2061164419 @default.
- W4282922900 cites W2061636085 @default.
- W4282922900 cites W2062750144 @default.
- W4282922900 cites W2066855248 @default.
- W4282922900 cites W2067079097 @default.
- W4282922900 cites W2067114948 @default.
- W4282922900 cites W2069449138 @default.
- W4282922900 cites W2069561698 @default.
- W4282922900 cites W2071748129 @default.
- W4282922900 cites W2073012102 @default.
- W4282922900 cites W2073025833 @default.
- W4282922900 cites W2073704608 @default.
- W4282922900 cites W2074100053 @default.
- W4282922900 cites W2078450813 @default.
- W4282922900 cites W2080270299 @default.
- W4282922900 cites W2080368151 @default.
- W4282922900 cites W2084166629 @default.
- W4282922900 cites W2087414462 @default.
- W4282922900 cites W2088115176 @default.
- W4282922900 cites W2088235470 @default.
- W4282922900 cites W2090450925 @default.
- W4282922900 cites W2091807741 @default.
- W4282922900 cites W2093771834 @default.
- W4282922900 cites W2095389499 @default.
- W4282922900 cites W2098657151 @default.
- W4282922900 cites W2104282986 @default.
- W4282922900 cites W2108986259 @default.
- W4282922900 cites W2109635701 @default.
- W4282922900 cites W2117693611 @default.
- W4282922900 cites W2120081179 @default.