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- W4282923882 abstract "Abstract The particulate matter 2.5 (PM 2.5 ) from the chicken production system attaching large amounts of harmful substances and microbes, can cause lung injury and reduce productivity through prolonged breath. Here, the basal epithelial cell of human lung adenocarcinoma (A549 cell) were subjected to PM 2.5 from the broiler breeding house to investigate the apoptosis induced by PM 2.5 as well as the anti-apoptotic effect of melatonin. The data showed that PM 2.5 (6.25, 12.5, and 25 μg/ml) increased the number of apoptotic cells substantially. The relative mRNA expression of Bcl-2 , Bad , Bax , PERK and CHOP increased dramatically in PM 2.5 treated groups. Furthermore, PM 2.5 exposure upregulated the level of cleaved caspase-9 and cleaved caspase-3 as well as the endoplasmic reticulum stress (ERS) related protein including ATF6 and CHOP. Melatonin increased the viability of A549 cells and declined the relative mRNA expression of Bcl-2 , Bax , Bad , cleaved caspase-3, cleaved caspase-9 in comparison with that exposed to PM 2.5 . Importantly, melatonin decreased the level of Nrf2, MDA, and enhanced the intracellular content of T-SOD and CAT after treatment by PM 2.5 . Collectively, our study proved that PM 2.5 from chicken house induced A549 cell apoptosis, and melatonin exerted an anti-apoptotic role on A549 cells by enhancing their antioxidative ability." @default.
- W4282923882 created "2022-06-16" @default.
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- W4282923882 date "2022-06-14" @default.
- W4282923882 modified "2023-10-16" @default.
- W4282923882 title "Melatonin reverted apoptosis induced by chicken house PM2.5 in A549 cell via oxidation resistance" @default.
- W4282923882 doi "https://doi.org/10.21203/rs.3.rs-1722882/v1" @default.
- W4282923882 hasPublicationYear "2022" @default.
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