FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282926151> ?p ?o ?g. }

• W4282926151 endingPage "106227" @default.
• W4282926151 startingPage "106227" @default.
• W4282926151 abstract "The transition to include in vitro-based data in chemical hazard assessment has resulted in the development and implementation of screening assays to cover a diversity of biological pathways, including recently added assays to interrogate chemical disruption of proteins relevant to thyroid signaling pathways. Iodotyrosine deiodinase (IYD), the iodide recycling enzyme, is one such thyroid-relevant endpoint for which a human-based screening assay has recently been developed and used to screen large libraries of chemicals. Presented here is the development of an amphibian IYD inhibition assay and its implementation to conduct a cross-species comparison between chemical inhibition of mammalian and non-mammalian IYD enzyme activity. The successful development of an amphibian IYD inhibition assay was based on demonstration of sufficient IYD enzyme activity in several tissues collected from larval Xenopus laevis. With this new assay, 154 chemicals were tested in concentration-response to provide a basis for comparison of relative chemical potency to results obtained from the human IYD assay. Most chemicals exhibited similar inhibition in both assays, with less than 25% variation in median inhibition for 120 of 154 chemicals and 85% concordance in categorization of “active” (potential IYD inhibitor) versus “inactive”. For chemicals that produced 50% or greater inhibition in both assays, rank-order potency was similar, with the majority of the IC50s varying by less than 2-fold (and all within an order of magnitude). Most differences resulted from greater maximum inhibition or higher chemical potency observed with human IYD. This strong cross-species agreement suggests that results from the human-based assay would be conservatively predictive of chemical effects on amphibian IYD." @default.
• W4282926151 created "2022-06-16" @default.
• W4282926151 creator A5002582359 @default.
• W4282926151 creator A5010406046 @default.
• W4282926151 creator A5023836907 @default.
• W4282926151 creator A5038802400 @default.
• W4282926151 creator A5085713473 @default.
• W4282926151 date "2022-08-01" @default.
• W4282926151 modified "2023-09-30" @default.
• W4282926151 title "Cross-species comparison of chemical inhibition of human and Xenopus iodotyrosine deiodinase" @default.
• W4282926151 cites W1632351542 @default.
• W4282926151 cites W1925071458 @default.
• W4282926151 cites W1968852740 @default.
• W4282926151 cites W1971971716 @default.
• W4282926151 cites W1986222814 @default.
• W4282926151 cites W1987580591 @default.
• W4282926151 cites W1988436502 @default.
• W4282926151 cites W1988915043 @default.
• W4282926151 cites W1991001144 @default.
• W4282926151 cites W1992101257 @default.
• W4282926151 cites W1994393818 @default.
• W4282926151 cites W2006324407 @default.
• W4282926151 cites W2012133139 @default.
• W4282926151 cites W2018437049 @default.
• W4282926151 cites W2025112777 @default.
• W4282926151 cites W2050886268 @default.
• W4282926151 cites W2052875054 @default.
• W4282926151 cites W2063062076 @default.
• W4282926151 cites W2064990262 @default.
• W4282926151 cites W2071450491 @default.
• W4282926151 cites W2091346859 @default.
• W4282926151 cites W2095253816 @default.
• W4282926151 cites W2095256089 @default.
• W4282926151 cites W2098942180 @default.
• W4282926151 cites W2107892821 @default.
• W4282926151 cites W2108772098 @default.
• W4282926151 cites W2120181483 @default.
• W4282926151 cites W2136959060 @default.
• W4282926151 cites W2152498124 @default.
• W4282926151 cites W2162358004 @default.
• W4282926151 cites W2212640525 @default.
• W4282926151 cites W2284803700 @default.
• W4282926151 cites W2340832791 @default.
• W4282926151 cites W2531103651 @default.
• W4282926151 cites W2546044736 @default.
• W4282926151 cites W2564631000 @default.
• W4282926151 cites W2580984977 @default.
• W4282926151 cites W2771655048 @default.
• W4282926151 cites W2888491241 @default.
• W4282926151 cites W2890847308 @default.
• W4282926151 cites W2904323763 @default.
• W4282926151 cites W2906336043 @default.
• W4282926151 cites W2919637418 @default.
• W4282926151 cites W2955167367 @default.
• W4282926151 cites W2969269463 @default.
• W4282926151 cites W2972209952 @default.
• W4282926151 cites W2980397948 @default.
• W4282926151 cites W2995593899 @default.
• W4282926151 cites W3084356065 @default.
• W4282926151 cites W3092150875 @default.
• W4282926151 cites W3117099702 @default.
• W4282926151 cites W3134417709 @default.
• W4282926151 cites W64744008 @default.
• W4282926151 doi "https://doi.org/10.1016/j.aquatox.2022.106227" @default.
• W4282926151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35767922" @default.
• W4282926151 hasPublicationYear "2022" @default.
• W4282926151 type Work @default.
• W4282926151 citedByCount "4" @default.
• W4282926151 countsByYear W42829261512022 @default.
• W4282926151 countsByYear W42829261512023 @default.
• W4282926151 crossrefType "journal-article" @default.
• W4282926151 hasAuthorship W4282926151A5002582359 @default.
• W4282926151 hasAuthorship W4282926151A5010406046 @default.
• W4282926151 hasAuthorship W4282926151A5023836907 @default.
• W4282926151 hasAuthorship W4282926151A5038802400 @default.
• W4282926151 hasAuthorship W4282926151A5085713473 @default.
• W4282926151 hasBestOaLocation W42829261512 @default.
• W4282926151 hasConcept C104317684 @default.
• W4282926151 hasConcept C104488531 @default.
• W4282926151 hasConcept C181199279 @default.
• W4282926151 hasConcept C185592680 @default.
• W4282926151 hasConcept C18903297 @default.
• W4282926151 hasConcept C202751555 @default.
• W4282926151 hasConcept C2779535977 @default.
• W4282926151 hasConcept C55493867 @default.
• W4282926151 hasConcept C57992300 @default.
• W4282926151 hasConcept C86803240 @default.
• W4282926151 hasConceptScore W4282926151C104317684 @default.
• W4282926151 hasConceptScore W4282926151C104488531 @default.
• W4282926151 hasConceptScore W4282926151C181199279 @default.
• W4282926151 hasConceptScore W4282926151C185592680 @default.
• W4282926151 hasConceptScore W4282926151C18903297 @default.
• W4282926151 hasConceptScore W4282926151C202751555 @default.
• W4282926151 hasConceptScore W4282926151C2779535977 @default.
• W4282926151 hasConceptScore W4282926151C55493867 @default.
• W4282926151 hasConceptScore W4282926151C57992300 @default.
• W4282926151 hasConceptScore W4282926151C86803240 @default.
• W4282926151 hasFunder F4320306107 @default.

• next