FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282926439> ?p ?o ?g. }

• W4282926439 endingPage "1115" @default.
• W4282926439 startingPage "1089" @default.
• W4282926439 abstract "Breast cancer (BC) is the most extensively accounted malignancy among the women across the globe and is treatable in 70–80% of patients with early-stage, non-metastatic cancer. The current available therapies have been found to be less effective to treat distant organ metastases and advanced breast cancers. The clinical efficacy hugely suffers from chemoresistance, non-specific toxicity, relapse and other associated adverse effects. Furthermore, lack of controlled delivery and effective temporospatial presence of chemotherapeutics has resulted in suboptimal therapeutic response. Nanotechnology based approaches have been widely used over the period as they are nanometric, offer controlled and site-specific drug release along with reduced toxicity, improved half-life, and stability. Lipid-based nanoplatforms have grabbed a tremendous attention for delivering cancer therapeutics as they are cost-effective, scalable and provide better entrapment efficiency. In this review, all the promising applications of lipid-engineered nanotechnological tools for breast cancer will be summarized and discussed. Subsequently, BC therapy achieved with the aid of chemotherapeutics, phytomedicine, genes, peptides, photosensitizers, diagnostic and immunogenic agents etc. will be reviewed and discussed. This review gives tabular information on all the results obtained pertaining to the physicochemical properties of the lipidic nanocarrier, in vitro studies conferring to mechanistic drug release profile, cell viability, cellular apoptosis and in vivo studies referring to cellular internalisation, reduction of tumor volume, PK-PD profile, bioavailability achieved and anti-tumor activity in detail. It also gives complete information on the most relevant clinical trials done on lipidic nanoplatforms over two decades in tabular form. The review highlights the current status and future prospects of lipidic nanoplatforms with streamlined focus on cancer nanotherapeutics." @default.
• W4282926439 created "2022-06-16" @default.
• W4282926439 creator A5006519161 @default.
• W4282926439 creator A5006794720 @default.
• W4282926439 creator A5042806503 @default.
• W4282926439 creator A5055468409 @default.
• W4282926439 creator A5076147458 @default.
• W4282926439 date "2022-08-01" @default.
• W4282926439 modified "2023-10-05" @default.
• W4282926439 title "Applications of lipid-engineered nanoplatforms in the delivery of various cancer therapeutics to surmount breast cancer" @default.
• W4282926439 cites W1952308954 @default.
• W4282926439 cites W1965930663 @default.
• W4282926439 cites W1968578128 @default.
• W4282926439 cites W1978708377 @default.
• W4282926439 cites W1986232860 @default.
• W4282926439 cites W1990564205 @default.
• W4282926439 cites W1991687987 @default.
• W4282926439 cites W1999293453 @default.
• W4282926439 cites W2002643165 @default.
• W4282926439 cites W2003102747 @default.
• W4282926439 cites W2018211378 @default.
• W4282926439 cites W2031300970 @default.
• W4282926439 cites W2043716501 @default.
• W4282926439 cites W2083190655 @default.
• W4282926439 cites W2083413248 @default.
• W4282926439 cites W2085043731 @default.
• W4282926439 cites W2094422744 @default.
• W4282926439 cites W2101600783 @default.
• W4282926439 cites W2113097471 @default.
• W4282926439 cites W2151467658 @default.
• W4282926439 cites W2157736127 @default.
• W4282926439 cites W2265730117 @default.
• W4282926439 cites W2294999722 @default.
• W4282926439 cites W2336643532 @default.
• W4282926439 cites W2440586629 @default.
• W4282926439 cites W2474572083 @default.
• W4282926439 cites W2507967283 @default.
• W4282926439 cites W2508626444 @default.
• W4282926439 cites W2511610444 @default.
• W4282926439 cites W2518313831 @default.
• W4282926439 cites W2520319673 @default.
• W4282926439 cites W2533615066 @default.
• W4282926439 cites W2549204000 @default.
• W4282926439 cites W2553770458 @default.
• W4282926439 cites W2594099172 @default.
• W4282926439 cites W2621656167 @default.
• W4282926439 cites W2741362686 @default.
• W4282926439 cites W2745134670 @default.
• W4282926439 cites W2765841571 @default.
• W4282926439 cites W2766862061 @default.
• W4282926439 cites W2767803625 @default.
• W4282926439 cites W2771263811 @default.
• W4282926439 cites W2779133494 @default.
• W4282926439 cites W2799411754 @default.
• W4282926439 cites W2802912669 @default.
• W4282926439 cites W2805332531 @default.
• W4282926439 cites W2808783127 @default.
• W4282926439 cites W2810417738 @default.
• W4282926439 cites W2884247479 @default.
• W4282926439 cites W2890605119 @default.
• W4282926439 cites W2893291240 @default.
• W4282926439 cites W2901451421 @default.
• W4282926439 cites W2901812954 @default.
• W4282926439 cites W2905543221 @default.
• W4282926439 cites W2906894949 @default.
• W4282926439 cites W2910346583 @default.
• W4282926439 cites W2911425042 @default.
• W4282926439 cites W2911958195 @default.
• W4282926439 cites W2913996232 @default.
• W4282926439 cites W2921932416 @default.
• W4282926439 cites W2924280186 @default.
• W4282926439 cites W2953278595 @default.
• W4282926439 cites W2964167215 @default.
• W4282926439 cites W2964749580 @default.
• W4282926439 cites W2965455997 @default.
• W4282926439 cites W2966269048 @default.
• W4282926439 cites W2968797919 @default.
• W4282926439 cites W2972933987 @default.
• W4282926439 cites W2973126765 @default.
• W4282926439 cites W2980637701 @default.
• W4282926439 cites W2986227597 @default.
• W4282926439 cites W2986483031 @default.
• W4282926439 cites W2998873738 @default.
• W4282926439 cites W3000276797 @default.
• W4282926439 cites W3000318240 @default.
• W4282926439 cites W3000869056 @default.
• W4282926439 cites W3002080991 @default.
• W4282926439 cites W3005608299 @default.
• W4282926439 cites W3007601922 @default.
• W4282926439 cites W3011430525 @default.
• W4282926439 cites W3015311364 @default.
• W4282926439 cites W3015828571 @default.
• W4282926439 cites W3022610090 @default.
• W4282926439 cites W3024872581 @default.
• W4282926439 cites W3032727553 @default.
• W4282926439 cites W3083054092 @default.
• W4282926439 cites W3083165862 @default.
• W4282926439 cites W3095925604 @default.

• next