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- W4282927172 abstract "The herb Oroxylum indicum has been used for treating several diseases and also has anticancer activity. This research examined the anticancer effects of ethanolic extract of O. indicum seeds on HeLa cervical cancer cells and investigates underlying mechanisms. The data indicated that the extract inhibited HeLa cells growth with low IC50 values and arrested the cell cycle at G0/G1 phase at a dose of 50 μg/mL. Moreover, this extract produced a marked increase in the apoptosis of cancer cells which was demonstrated by acridine orange/ethidium bromide (AO/EB) staining and was significant at a dose of 250 μg/mL for 24 h. Correlating with apoptotic data by flow cytometric analysis, the results indicated that viable cells were significantly reduced and late apoptotic cells were induced starting at the dose of 50 μg/mL of the extract. These extracts significantly induced cancer cell apoptosis which was mediating through reduction of mitochondrial function by stimulating intracellular reactive oxygen species (ROS) formation. Furthermore, the extract caused inactivation of cervical cancer cell migration and was detected with the wound healing method. The data in this study strongly indicated that O. indicum seed extract has powerful activity against cervical cancer." @default.
- W4282927172 created "2022-06-16" @default.
- W4282927172 date "2022-03-01" @default.
- W4282927172 modified "2023-09-29" @default.
- W4282927172 title "The seed extract of Oroxylum indicum suppresses cell proliferation, migration and promotes apoptosis in cervical cancer cells." @default.
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