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• W4282927587 abstract "To observe the occurrence of immune dysfunction in children with aplastic anemia (AA) and the factors that may lead to immune dysfunction, analyze the relationship between the expression of granulocyte colony stimulating factor (G-CSF) and immune dysfunction.A total of 34 children with AA treated in our hospital from December 2016 to September 2018 were selected. All the children received immunosuppressive therapy (IST) for 6 months. According to whether the children had immune dysfunction after 6 months of treatment, they were divided into occurrence group and non occurrence group. General information and laboratory indices were compared between the two groups, and serum G-CSF level was tested, the relationship between serum G-CSF level and immune dysfunction in AA children after treatment with IST was observed and analyzed.After treatment with IST for 6 months, 12 cases developed immune dysfunction (35.29%). Serum interferon (IFN)-γ level of the occurrence group was higher but G-CSF level was lower than those of the non occurrence group (P<0.05), while the difference of other baseline data was not statistically significant (P>0.05). Multiple regression analysis showed that overexpression of serum IFN-γ and low expression of G-CSF were both the influencing factors of immune dysfunction in AA children after IST treatment (OR>1, P<0.05). ROC curve was drawn, and the result showed that the area under the curve (AUC) of serum G-CSF level predicted the risk of immune dysfunction after IST was 0.843>0.80, when the index cut-off value was set at 6.614 pg/ml, the predictive value was ideal.AA children have a higher risk of immune dysfunction after IST, which may be related to the low expression of serum G-CSF. The detection of serum G-CSF expression can be considered to predict the risk of immune dysfunction in AA children after IST, so as to guide early clinical intervention.血清G-CSF水平与再生障碍性贫血患儿免疫功能的相关性.观察再生障碍性贫血患儿免疫功能障碍发生情况及可能导致免疫功能障碍的因素，分析粒细胞集落刺激因子（G-CSF）的表达与免疫功能障碍的关系.选取2016年12月-2018年9月在本院接受治疗的34例再生障碍性贫血患儿，均接受免疫抑制治疗6个月。依据治疗6个月后患儿有无发生免疫功能障碍分为发生组与未发生组，比较两组患儿一般资料、实验室指标，检测血清G-CSF水平，观察并分析血清G-CSF水平与治疗后发生免疫功能障碍的关系.患儿经免疫抑制治疗6个月后，发生免疫功能障碍12例(35.29%)，发生组血清干扰素-γ水平明显高于未发生组（P<0.05），G-CSF水平明显低于未发生组（P<0.05），而其他基线资料比较差异无统计学意义（P>0.05）。多元回归分析显示血清干扰素-γ过表达、G-CSF低表达均是再生障碍性贫血患儿经免疫抑制治疗后发生免疫功能障碍的影响因素（OR>1，P<0.05）。绘制ROC曲线结果显示，血清G-CSF水平预测治疗后发生免疫功能障碍风险的曲线下面积为0.843>0.80，在指标cut-off值取6.614 pg/ml时预测价值较理想.再生障碍性贫血患儿经免疫抑制治疗后有较高的免疫功能障碍发生风险，可能与血清G-CSF低表达有关，临床可考虑通过检测血清G-CSF表达预测免疫功能障碍发生风险，以指导早期干预." @default.
• W4282927587 created "2022-06-16" @default.
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• W4282927587 date "2022-06-01" @default.
• W4282927587 modified "2023-10-16" @default.
• W4282927587 title "[Correlation between Serum G-CSF Level and Immune Function in Children with Aplastic Anemia]." @default.
• W4282927587 doi "https://doi.org/10.19746/j.cnki.issn.1009-2137.2022.03.025" @default.
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