Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282929081> ?p ?o ?g. }
- W4282929081 endingPage "256" @default.
- W4282929081 startingPage "239" @default.
- W4282929081 abstract "During sepsis, an initial prothrombotic shift takes place, in which coagulatory acute-phase proteins are increased, while anticoagulatory factors and platelet count decrease. Further on, the fibrinolytic system becomes impaired, which contributes to disease severity. At a later stage in sepsis, coagulation factors may become depleted, and sepsis patients may shift into a hypo-coagulable state with an increased bleeding risk. During the pro-coagulatory shift, critically ill patients have an increased thrombosis risk that ranges from developing micro-thromboses that impair organ function to life-threatening thromboembolic events. Here, thrombin plays a key role in coagulation as well as in inflammation. For thromboprophylaxis, low molecular weight heparins (LMWH) and unfractionated heparins (UFHs) are recommended. Nevertheless, there are conditions such as heparin resistance or heparin-induced thrombocytopenia (HIT), wherein heparin becomes ineffective or even puts the patient at an increased prothrombotic risk. In these cases, argatroban, a direct thrombin inhibitor (DTI), might be a potential alternative anticoagulatory strategy. Yet, caution is advised with regard to dosing of argatroban especially in sepsis. Therefore, the starting dose of argatroban is recommended to be low and should be titrated to the targeted anticoagulation level and be closely monitored in the further course of treatment. The authors of this review recommend using DTIs such as argatroban as an alternative anticoagulant in critically ill patients suffering from sepsis or COVID-19 with suspected or confirmed HIT, HIT-like conditions, impaired fibrinolysis, in patients on extracorporeal circuits and patients with heparin resistance, when closely monitored." @default.
- W4282929081 created "2022-06-16" @default.
- W4282929081 creator A5001586855 @default.
- W4282929081 creator A5003060502 @default.
- W4282929081 creator A5003592595 @default.
- W4282929081 creator A5052163867 @default.
- W4282929081 creator A5056971117 @default.
- W4282929081 creator A5059080067 @default.
- W4282929081 creator A5070142708 @default.
- W4282929081 creator A5078496632 @default.
- W4282929081 creator A5084740463 @default.
- W4282929081 date "2022-06-08" @default.
- W4282929081 modified "2023-10-01" @default.
- W4282929081 title "Thromboprophylaxis with argatroban in critically ill patients with sepsis: a review" @default.
- W4282929081 cites W1480474887 @default.
- W4282929081 cites W1634577593 @default.
- W4282929081 cites W1644695642 @default.
- W4282929081 cites W1658287483 @default.
- W4282929081 cites W1950689131 @default.
- W4282929081 cites W1952966745 @default.
- W4282929081 cites W1965833894 @default.
- W4282929081 cites W1967450624 @default.
- W4282929081 cites W1968751632 @default.
- W4282929081 cites W1970339861 @default.
- W4282929081 cites W1971119013 @default.
- W4282929081 cites W1972865736 @default.
- W4282929081 cites W1973572495 @default.
- W4282929081 cites W1975704243 @default.
- W4282929081 cites W1981066988 @default.
- W4282929081 cites W1982196709 @default.
- W4282929081 cites W1982819652 @default.
- W4282929081 cites W1986139740 @default.
- W4282929081 cites W1987775704 @default.
- W4282929081 cites W1988839103 @default.
- W4282929081 cites W1990840000 @default.
- W4282929081 cites W1995116261 @default.
- W4282929081 cites W1998423205 @default.
- W4282929081 cites W1999433402 @default.
- W4282929081 cites W2000499186 @default.
- W4282929081 cites W2003201146 @default.
- W4282929081 cites W2006175341 @default.
- W4282929081 cites W2010788455 @default.
- W4282929081 cites W2014158378 @default.
- W4282929081 cites W2016962787 @default.
- W4282929081 cites W2017431600 @default.
- W4282929081 cites W2017847655 @default.
- W4282929081 cites W2020581191 @default.
- W4282929081 cites W2020771979 @default.
- W4282929081 cites W2023313790 @default.
- W4282929081 cites W2025631144 @default.
- W4282929081 cites W2027093124 @default.
- W4282929081 cites W2029884260 @default.
- W4282929081 cites W2034352216 @default.
- W4282929081 cites W2037149159 @default.
- W4282929081 cites W2041353961 @default.
- W4282929081 cites W2041702736 @default.
- W4282929081 cites W2041892054 @default.
- W4282929081 cites W2043788794 @default.
- W4282929081 cites W2045995910 @default.
- W4282929081 cites W2046546511 @default.
- W4282929081 cites W2048027358 @default.
- W4282929081 cites W2048855922 @default.
- W4282929081 cites W2049927822 @default.
- W4282929081 cites W2051752982 @default.
- W4282929081 cites W2051948460 @default.
- W4282929081 cites W2054728105 @default.
- W4282929081 cites W2054730686 @default.
- W4282929081 cites W205949780 @default.
- W4282929081 cites W2060936970 @default.
- W4282929081 cites W2064308920 @default.
- W4282929081 cites W2064369146 @default.
- W4282929081 cites W2064674149 @default.
- W4282929081 cites W2067320587 @default.
- W4282929081 cites W2068516100 @default.
- W4282929081 cites W2068796527 @default.
- W4282929081 cites W2070741400 @default.
- W4282929081 cites W2071195145 @default.
- W4282929081 cites W2073637661 @default.
- W4282929081 cites W2074209458 @default.
- W4282929081 cites W2076219869 @default.
- W4282929081 cites W2081753893 @default.
- W4282929081 cites W2083163901 @default.
- W4282929081 cites W2085156383 @default.
- W4282929081 cites W2085429095 @default.
- W4282929081 cites W2087447055 @default.
- W4282929081 cites W2087466165 @default.
- W4282929081 cites W2089771664 @default.
- W4282929081 cites W2090523994 @default.
- W4282929081 cites W2090801464 @default.
- W4282929081 cites W2091112630 @default.
- W4282929081 cites W2093552000 @default.
- W4282929081 cites W2094727019 @default.
- W4282929081 cites W2095089544 @default.
- W4282929081 cites W2095965463 @default.
- W4282929081 cites W2097260198 @default.
- W4282929081 cites W2098382673 @default.
- W4282929081 cites W2101084498 @default.
- W4282929081 cites W2101979147 @default.