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- W4282930741 endingPage "1324" @default.
- W4282930741 startingPage "1305" @default.
- W4282930741 abstract "Covering: up to February 2022Naturally occurring dimeric molecules attract considerable attention from both chemists and biologists. The methylene-bridged dimers with one-carbon (C1) unit in biosynthesis, which are a small class of structurally diverse natural products, are found in plants, microorganisms, and marine bryozoan. Some individual dimers showed more significant biological activities than the corresponding monomers. Focusing on these dimers with a methylene linker, we here reviewed associated progress in the isolation, biological activity, chemical synthesis, and the proposed dimerization mechanism. The structural characteristics of the monomeric substrates are summarized, which indicated that most of these dimers might be formed through nonenzymatic dimerization involving a strong electrophilic C1 unit such as formaldehyde. This kind of dimerization is an effective synthetic strategy for the discovery of new biologically active compounds." @default.
- W4282930741 created "2022-06-16" @default.
- W4282930741 creator A5004858623 @default.
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- W4282930741 creator A5059749674 @default.
- W4282930741 creator A5065356687 @default.
- W4282930741 creator A5070605952 @default.
- W4282930741 date "2022-01-01" @default.
- W4282930741 modified "2023-10-16" @default.
- W4282930741 title "Methylene-bridged dimeric natural products involving one-carbon unit in biosynthesis" @default.
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