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- W4282931802 abstract "The triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition receptor, which can be upregulated in inflammatory diseases as an amplifier of immune responses. Once activated, TREM-1 induces the production and release of pro-inflammatory cytokines and chemokines, in addition to increasing its own expression and circulating levels of the cleaved soluble extracellular portion of TREM-1 (sTREM-1). This amplification of the inflammatory response by TREM-1 has now been considered as a critical contributor to the dysregulated immune responses in sepsis. Studies have shown that in septic patients there is an elevated expression of TREM-1 on immune cells and increased circulating levels of sTREM-1, associated with increased mortality. As a result, a considerable effort has been made towards identifying endogenous ligands of TREM-1 and developing TREM-1 inhibitory peptides to attenuate the exacerbated inflammatory response in sepsis. TREM-1 modulation has proven a promising strategy for the development of therapeutic agents to treat sepsis. Therefore, this review encompasses the ligands investigated as activators of TREM-1 thus far and highlights the development and efficacy of novel inhibitors for the treatment of sepsis and septic shock." @default.
- W4282931802 created "2022-06-16" @default.
- W4282931802 creator A5013736647 @default.
- W4282931802 creator A5090798506 @default.
- W4282931802 creator A5091249453 @default.
- W4282931802 date "2022-06-15" @default.
- W4282931802 modified "2023-10-14" @default.
- W4282931802 title "TREM-1 Modulation Strategies for Sepsis" @default.
- W4282931802 cites W1415317716 @default.
- W4282931802 cites W1515599953 @default.
- W4282931802 cites W1544895579 @default.
- W4282931802 cites W1555274851 @default.
- W4282931802 cites W1592205939 @default.
- W4282931802 cites W1601476460 @default.
- W4282931802 cites W1643888758 @default.
- W4282931802 cites W1820398398 @default.
- W4282931802 cites W1972203656 @default.
- W4282931802 cites W1975815091 @default.
- W4282931802 cites W1983348216 @default.
- W4282931802 cites W1983615635 @default.
- W4282931802 cites W1986899130 @default.
- W4282931802 cites W1988487761 @default.
- W4282931802 cites W1990266088 @default.
- W4282931802 cites W1997550689 @default.
- W4282931802 cites W1997720276 @default.
- W4282931802 cites W1999783783 @default.
- W4282931802 cites W2000647523 @default.
- W4282931802 cites W2012325198 @default.
- W4282931802 cites W2016381907 @default.
- W4282931802 cites W2019558661 @default.
- W4282931802 cites W2024798843 @default.
- W4282931802 cites W2028432878 @default.
- W4282931802 cites W2033028058 @default.
- W4282931802 cites W2036514375 @default.
- W4282931802 cites W2051731334 @default.
- W4282931802 cites W2066332911 @default.
- W4282931802 cites W2069521331 @default.
- W4282931802 cites W2070271290 @default.
- W4282931802 cites W2080678175 @default.
- W4282931802 cites W2086964969 @default.
- W4282931802 cites W2091092330 @default.
- W4282931802 cites W2092035190 @default.
- W4282931802 cites W2097723042 @default.
- W4282931802 cites W2099204219 @default.
- W4282931802 cites W2104825124 @default.
- W4282931802 cites W2117532213 @default.
- W4282931802 cites W2118751252 @default.
- W4282931802 cites W2119593008 @default.
- W4282931802 cites W2121427946 @default.
- W4282931802 cites W2121631661 @default.
- W4282931802 cites W2126115734 @default.
- W4282931802 cites W2127785805 @default.
- W4282931802 cites W2128413447 @default.
- W4282931802 cites W2132812582 @default.
- W4282931802 cites W2132882829 @default.
- W4282931802 cites W2139347614 @default.
- W4282931802 cites W2143199244 @default.
- W4282931802 cites W2146857507 @default.
- W4282931802 cites W2147721514 @default.
- W4282931802 cites W2149698238 @default.
- W4282931802 cites W2150747928 @default.
- W4282931802 cites W2158062242 @default.
- W4282931802 cites W2158427654 @default.
- W4282931802 cites W2159245185 @default.
- W4282931802 cites W2160902858 @default.
- W4282931802 cites W2162123959 @default.
- W4282931802 cites W2179656941 @default.
- W4282931802 cites W2331764669 @default.
- W4282931802 cites W2402418349 @default.
- W4282931802 cites W2406217655 @default.
- W4282931802 cites W2473998526 @default.
- W4282931802 cites W2587693404 @default.
- W4282931802 cites W2590990413 @default.
- W4282931802 cites W2592985916 @default.
- W4282931802 cites W2608823051 @default.
- W4282931802 cites W2745285215 @default.
- W4282931802 cites W2764177287 @default.
- W4282931802 cites W2766516621 @default.
- W4282931802 cites W2780154392 @default.
- W4282931802 cites W2791460023 @default.
- W4282931802 cites W2805312595 @default.
- W4282931802 cites W2805631143 @default.
- W4282931802 cites W2896767268 @default.
- W4282931802 cites W2954926994 @default.
- W4282931802 cites W2961268895 @default.
- W4282931802 cites W2978484540 @default.
- W4282931802 cites W3000714998 @default.
- W4282931802 cites W3005232943 @default.
- W4282931802 cites W3005996142 @default.
- W4282931802 cites W3012116029 @default.
- W4282931802 cites W3023607005 @default.
- W4282931802 cites W3025651357 @default.
- W4282931802 cites W3032719613 @default.
- W4282931802 cites W3045078410 @default.
- W4282931802 cites W3082227471 @default.
- W4282931802 cites W3092285904 @default.
- W4282931802 cites W3108576934 @default.
- W4282931802 cites W3109275556 @default.
- W4282931802 cites W3110567498 @default.
- W4282931802 cites W3118828853 @default.