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- W4282932800 endingPage "265" @default.
- W4282932800 startingPage "253" @default.
- W4282932800 abstract "Clopidogrel is a widely prescribed prodrug with anti-thrombotic activity through irreversible inhibition of the P2Y12 receptor on platelets. It is FDA-approved for the clinical management of thrombotic diseases like unstable angina, myocardial infarction, stroke, and during percutaneous coronary interventions. Hepatic clopidogrel metabolism generates several distinct metabolites. Only one of these metabolites is responsible for inhibiting the platelet P2Y12 receptor. Importantly, various non-hemostatic effects of clopidogrel therapy have been described. These non-hemostatic effects are perhaps unsurprising, as P2Y12 receptor expression has been reported in multiple tissues, including osteoblasts, leukocytes, as well as vascular endothelium and smooth muscle. While the inactive metabolites have been commonly thought to be biologically inert, recent findings have uncovered P2Y12 receptor-independent effects of clopidogrel treatment that may be mediated by understudied metabolites. In this review, we summarize both the P2Y12 receptor-mediated and non-P2Y12 receptor-mediated effects of clopidogrel and its metabolites in various tissues." @default.
- W4282932800 created "2022-06-16" @default.
- W4282932800 creator A5067185795 @default.
- W4282932800 creator A5075497195 @default.
- W4282932800 date "2022-06-09" @default.
- W4282932800 modified "2023-10-02" @default.
- W4282932800 title "Pleiotropic effects of clopidogrel" @default.
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