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- W4282933265 endingPage "22.2022" @default.
- W4282933265 startingPage "ENEURO.0060" @default.
- W4282933265 abstract "The dendrites of cortical pyramidal neurons receive synaptic inputs from different pathways that are organized according to their laminar target. This architectural scheme provides cortical neurons with a spatial mechanism to separate information, which may support neural flexibility required during learning. Here, we investigated layer-specific plasticity of sensory encoding following learning by recording from two different dendritic compartments, tuft and basal dendrites, of layer 2/3 (L2/3) pyramidal neurons in the auditory cortex of mice. Following auditory fear conditioning, auditory-evoked Ca 2+ responses were enhanced in tuft, but not basal, dendrites leading to increased somatic action potential output. This is in direct contrast to the long held (and debated) hypothesis that, despite extensive dendritic arbors, neurons function as a simple one-compartment model. Two computational models of varying complexity based on the experimental data illustrated that this learning-related increase of auditory responses in tuft dendrites can account for the changes in somatic output. Taken together, we illustrate that neurons do not function as a single compartment, and dendritic compartmentalization of learning-related plasticity may act to increase the computational power of pyramidal neurons." @default.
- W4282933265 created "2022-06-16" @default.
- W4282933265 creator A5026846718 @default.
- W4282933265 creator A5042505692 @default.
- W4282933265 creator A5089087327 @default.
- W4282933265 date "2022-05-01" @default.
- W4282933265 modified "2023-10-18" @default.
- W4282933265 title "Dendritic Compartmentalization of Learning-Related Plasticity" @default.
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- W4282933265 doi "https://doi.org/10.1523/eneuro.0060-22.2022" @default.
- W4282933265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35701166" @default.
- W4282933265 hasPublicationYear "2022" @default.
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