Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282933604> ?p ?o ?g. }
- W4282933604 endingPage "906" @default.
- W4282933604 startingPage "897" @default.
- W4282933604 abstract "Psoriasis is a chronic autoimmune disease affecting over 2% of the worldwide population. From an anatomopathological point of view, psoriasis is characterized by immune cells infiltration, epidermal hyperproliferation, and abnormal keratinocyte differentiation. Understanding the pathogenesis of psoriasis will allow clinicians to manage this complex disease. Under these conditions, the application of effective treatments requires a thorough knowledge of all the pathogenetic mechanisms that lead to psoriasis. Numerous immunopathological pathways play crucial roles in the development of new therapies, such as biological therapies, which have been a breakthrough in psoriasis's treatment. Pharmacogenetics is an essential factor in the patient's response to treatment. One important pathway targeted by modern treatments is the interleukin (IL)-23∕T-helper (Th)17 axis. Like IL-17 inhibitors, IL-23 blockers are a very effective therapy for this autoimmune disease. It is considered that micro-ribonucleic acids (microRNAs) are the starting point for any autoimmune disease. Studying certain microRNA (miR) involved in the inflammatory pathway in psoriasis can find direct targets to future treatments that can even be more specific than actual biological therapies. As such, miR-210 has proven to be up-regulated in psoriasis, also leading to the up-regulation of the Th1∕Th17 axis. On the other hand, miR-187 was found to be down-regulated, influencing the outcome of psoriasis by increasing the proliferation of IL-6 stimulated keratinocytes and consecutively generating epidermal thickening. In this review, we are aiming to do an up-to-date briefing of psoriasis histopathology and pharmacogenetic factors that are considered for the accurate evaluation of treatment response." @default.
- W4282933604 created "2022-06-16" @default.
- W4282933604 creator A5006370238 @default.
- W4282933604 creator A5007070631 @default.
- W4282933604 creator A5007555709 @default.
- W4282933604 creator A5033729843 @default.
- W4282933604 creator A5061401105 @default.
- W4282933604 creator A5063511791 @default.
- W4282933604 creator A5064036045 @default.
- W4282933604 creator A5070941161 @default.
- W4282933604 creator A5077530342 @default.
- W4282933604 date "2022-06-07" @default.
- W4282933604 modified "2023-10-18" @default.
- W4282933604 title "Novel concepts in psoriasis: histopathology and markers related to modern treatment approaches" @default.
- W4282933604 cites W1488772574 @default.
- W4282933604 cites W1939997832 @default.
- W4282933604 cites W1964009691 @default.
- W4282933604 cites W1981924240 @default.
- W4282933604 cites W1986796394 @default.
- W4282933604 cites W1987392209 @default.
- W4282933604 cites W1991030828 @default.
- W4282933604 cites W2005428052 @default.
- W4282933604 cites W2012194172 @default.
- W4282933604 cites W2016954098 @default.
- W4282933604 cites W2019205814 @default.
- W4282933604 cites W2019320114 @default.
- W4282933604 cites W2020233428 @default.
- W4282933604 cites W2023380729 @default.
- W4282933604 cites W2024163966 @default.
- W4282933604 cites W2029128580 @default.
- W4282933604 cites W2033275545 @default.
- W4282933604 cites W2042087027 @default.
- W4282933604 cites W2043490207 @default.
- W4282933604 cites W2045065875 @default.
- W4282933604 cites W2045113343 @default.
- W4282933604 cites W2051174436 @default.
- W4282933604 cites W2062583318 @default.
- W4282933604 cites W2069070000 @default.
- W4282933604 cites W2069911991 @default.
- W4282933604 cites W2087905758 @default.
- W4282933604 cites W2103120331 @default.
- W4282933604 cites W2106686862 @default.
- W4282933604 cites W2107730744 @default.
- W4282933604 cites W2117601975 @default.
- W4282933604 cites W2121126920 @default.
- W4282933604 cites W2121588356 @default.
- W4282933604 cites W2131371764 @default.
- W4282933604 cites W2154661682 @default.
- W4282933604 cites W2162674813 @default.
- W4282933604 cites W2163504863 @default.
- W4282933604 cites W2167606334 @default.
- W4282933604 cites W2169758620 @default.
- W4282933604 cites W2203736446 @default.
- W4282933604 cites W2498376382 @default.
- W4282933604 cites W2499771932 @default.
- W4282933604 cites W2503969358 @default.
- W4282933604 cites W2515974373 @default.
- W4282933604 cites W2522689630 @default.
- W4282933604 cites W2522825068 @default.
- W4282933604 cites W2527420241 @default.
- W4282933604 cites W2701201582 @default.
- W4282933604 cites W2738316552 @default.
- W4282933604 cites W2794722370 @default.
- W4282933604 cites W2799871629 @default.
- W4282933604 cites W2801522626 @default.
- W4282933604 cites W2883186894 @default.
- W4282933604 cites W2889876934 @default.
- W4282933604 cites W2902141660 @default.
- W4282933604 cites W2902712114 @default.
- W4282933604 cites W2903830162 @default.
- W4282933604 cites W2946192037 @default.
- W4282933604 cites W2947452967 @default.
- W4282933604 cites W2953191080 @default.
- W4282933604 cites W2954341438 @default.
- W4282933604 cites W2955490166 @default.
- W4282933604 cites W2957938761 @default.
- W4282933604 cites W2971174910 @default.
- W4282933604 cites W2973246081 @default.
- W4282933604 cites W2981881986 @default.
- W4282933604 cites W3005854261 @default.
- W4282933604 cites W3007613675 @default.
- W4282933604 cites W3012744883 @default.
- W4282933604 cites W3013426388 @default.
- W4282933604 cites W3022677726 @default.
- W4282933604 cites W3032589454 @default.
- W4282933604 cites W3038645496 @default.
- W4282933604 cites W3082857523 @default.
- W4282933604 cites W3083746347 @default.
- W4282933604 cites W3088337877 @default.
- W4282933604 cites W3114789268 @default.
- W4282933604 cites W3122770937 @default.
- W4282933604 cites W3123676674 @default.
- W4282933604 cites W3128034858 @default.
- W4282933604 cites W3133859685 @default.
- W4282933604 cites W3135031130 @default.
- W4282933604 cites W3171197834 @default.
- W4282933604 cites W4211202219 @default.
- W4282933604 doi "https://doi.org/10.47162/rjme.62.4.02" @default.