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- W4282934390 abstract "We aimed to review the clinical and biological presentation of granulomatosis associated with immune-checkpoint inhibitors (ICI) in patients with melanoma and to explore its association with classical sarcoidosis as well as with cancer response to ICI. To this end, a retrospective study on 18 melanoma patients with histologically proven ICI-induced granulomatosis over a 12-year period in a single center, as well as on 67 similar cases reported in the literature, was conducted. Results indicate ICI-induced granulomatosis is an early side effect (median time to onset: 2 months). Its clinical presentation, with predominant (90%) thoracic involvement, histopathological appearance and supposed underlying biology (involving the mTOR pathway in immune cells, Th17 polarization and TReg dysfunction) are indistinguishable from those of sarcoidosis. Moreover, it appears to be associated with ICI benefit (>65% objective response rate). Evolution is generally favorable, and symptomatic steroid treatment and/or ICI discontinuation are rarely necessary. ICI-associated granulomatosis is critical to explore for several reasons. Practically, it is essential to differentiate it from cancer progression. Secondly, this “experimental” sarcoidosis brings new elements that may help to address sarcoidosis origin and pathophysiology. Its association with ICI efficacy must be confirmed on a larger scale but could have significant impacts on patient management and biomarker definition." @default.
- W4282934390 created "2022-06-16" @default.
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- W4282934390 date "2022-06-14" @default.
- W4282934390 modified "2023-10-17" @default.
- W4282934390 title "Sarcoid-like Granulomatosis Associated with Immune Checkpoint Inhibitors in Melanoma" @default.
- W4282934390 cites W1512129732 @default.
- W4282934390 cites W1540829185 @default.
- W4282934390 cites W1555527272 @default.
- W4282934390 cites W1901471279 @default.
- W4282934390 cites W1926049969 @default.
- W4282934390 cites W1943779301 @default.
- W4282934390 cites W1965469924 @default.
- W4282934390 cites W1970166962 @default.
- W4282934390 cites W1973168003 @default.
- W4282934390 cites W1977316020 @default.
- W4282934390 cites W1977582499 @default.
- W4282934390 cites W1980906172 @default.
- W4282934390 cites W2001975852 @default.
- W4282934390 cites W2017554236 @default.
- W4282934390 cites W2022849814 @default.
- W4282934390 cites W2031102521 @default.
- W4282934390 cites W2041271416 @default.
- W4282934390 cites W2056786522 @default.
- W4282934390 cites W2079122809 @default.
- W4282934390 cites W2085042500 @default.
- W4282934390 cites W2091482207 @default.
- W4282934390 cites W2097155234 @default.
- W4282934390 cites W2099100275 @default.
- W4282934390 cites W2106938658 @default.
- W4282934390 cites W2109219217 @default.
- W4282934390 cites W2112929305 @default.
- W4282934390 cites W2118006960 @default.
- W4282934390 cites W2122096722 @default.
- W4282934390 cites W2128035403 @default.
- W4282934390 cites W2131765674 @default.
- W4282934390 cites W2133075384 @default.
- W4282934390 cites W2137051908 @default.
- W4282934390 cites W2137712039 @default.
- W4282934390 cites W2137738343 @default.
- W4282934390 cites W2140254549 @default.
- W4282934390 cites W2140875987 @default.
- W4282934390 cites W2143432487 @default.
- W4282934390 cites W2146879458 @default.
- W4282934390 cites W2157291255 @default.
- W4282934390 cites W2162423605 @default.
- W4282934390 cites W2163441724 @default.
- W4282934390 cites W2165241714 @default.
- W4282934390 cites W2167405859 @default.
- W4282934390 cites W2191026300 @default.
- W4282934390 cites W2301851804 @default.
- W4282934390 cites W2337182969 @default.
- W4282934390 cites W2347127875 @default.
- W4282934390 cites W2415408332 @default.
- W4282934390 cites W2417721321 @default.
- W4282934390 cites W2473436549 @default.
- W4282934390 cites W2487303921 @default.
- W4282934390 cites W2507916163 @default.
- W4282934390 cites W2513710094 @default.
- W4282934390 cites W2560367415 @default.
- W4282934390 cites W2563735287 @default.
- W4282934390 cites W2573501158 @default.
- W4282934390 cites W2588144362 @default.
- W4282934390 cites W2610600861 @default.
- W4282934390 cites W2613642472 @default.
- W4282934390 cites W2737654646 @default.
- W4282934390 cites W2753363149 @default.
- W4282934390 cites W2753432434 @default.
- W4282934390 cites W2754597397 @default.
- W4282934390 cites W2766982226 @default.
- W4282934390 cites W2775591256 @default.
- W4282934390 cites W2776320342 @default.
- W4282934390 cites W2783621911 @default.
- W4282934390 cites W2794330011 @default.
- W4282934390 cites W2795596514 @default.
- W4282934390 cites W2796327298 @default.
- W4282934390 cites W2799401120 @default.
- W4282934390 cites W2803300058 @default.
- W4282934390 cites W2806291169 @default.
- W4282934390 cites W2883285683 @default.
- W4282934390 cites W2883399237 @default.
- W4282934390 cites W2884934764 @default.
- W4282934390 cites W2885776529 @default.
- W4282934390 cites W2891741399 @default.
- W4282934390 cites W2898298658 @default.
- W4282934390 cites W2899424980 @default.
- W4282934390 cites W2902167496 @default.
- W4282934390 cites W2904380898 @default.
- W4282934390 cites W2939112444 @default.