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• W4282935364 abstract "Histomonas meleagridis is an anaerobic, intercellular parasite, which infects gallinaceous birds such as turkeys and chickens. In recent years, the reemergence of Histomoniasis has caused serious economic losses as drugs to treat the disease have been banned. At present, H. meleagridis research focuses on virulence, gene expression analysis, and the innate immunity of the host. However, there are no studies on the differentially expressed miRNAs (DEMs) associated with the host inflammatory and immune responses induced by H. meleagridis. In this research, high-throughput sequencing was used to analyze the expression profile of cecum miRNA at 10 and 15 days post-infection (DPI) in chickens infected with Chinese JSYZ-F strain H. meleagridis.Compared with the controls, 94 and 127 DEMs were found in cecum of infected chickens at 10 DPI (CE vs CC) and 15 DPI (CEH vs CCH), respectively, of which 60 DEMs were shared at two-time points. Gene Ontology (GO) functional enrichment analysis of the target genes of DEMs indicated that 881 and 1027 GO terms were significantly enriched at 10 and 15 DPI, respectively. Kyoto Encyclopedia of Genes and Genomes (KEGG, www.kegg.jp/kegg/kegg1.html ) pathway enrichment analysis of the target genes of DEMs demonstrated that 5 and 3 KEGG pathways were significantly enriched at 10 and 15 DPI, respectively. For previous uses, the Kanehisa laboratory have happily provided permission. The integrated analysis of miRNA-gene network revealed that the DEMs played important roles in the host inflammatory and immune responses to H. meleagridis infection by dynamically regulating expression levels of inflammation and immune-related cytokines.This article not only suggested that host miRNA expression was dynamically altered by H. meleagridis and host but also revealed differences in the regulation of T cell involved in host responses to different times H. meleagridis infection." @default.
• W4282935364 created "2022-06-16" @default.
• W4282935364 creator A5005715004 @default.
• W4282935364 creator A5006349365 @default.
• W4282935364 creator A5009927168 @default.
• W4282935364 creator A5017298015 @default.
• W4282935364 creator A5020260492 @default.
• W4282935364 creator A5031858238 @default.
• W4282935364 creator A5035520440 @default.
• W4282935364 creator A5063253432 @default.
• W4282935364 creator A5065548055 @default.
• W4282935364 date "2022-06-11" @default.
• W4282935364 modified "2023-09-24" @default.
• W4282935364 title "MicroRNA expression profile of chicken cecum in different stages during Histomonas meleagridis infection" @default.
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