Matches in SemOpenAlex for { <https://semopenalex.org/work/W4282935823> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4282935823 endingPage "039463202211056" @default.
- W4282935823 startingPage "039463202211056" @default.
- W4282935823 abstract "Introduction: Increasing evidence has indicated that LINC00680 represents an oncogenic factor in cancer; however, the mechanism by which LINC00680 contributes to breast cancer (BC) remains unknown. Methods: A dual-luciferase reporter assay was used to explore the relationship between LINC00680, miR-320b, and cyclin-dependent kinase 5 (CDKL5). A CCK-8 assay and transwell assay were utilized to evaluate the proliferation and invasion in docetaxel-resistant BC cells, respectively. Results: LINC00680 and CDKL5 protein levels were both upregulated when induced by different concentrations of docetaxel. LINC00680 knockdown decreased the expression level of drug resistance-related genes, proliferation, and invasion of BC cells. Bioinformatics prediction and dual-luciferase assays revealed that miR-320b targeted the 3'-unstranslated regions (UTR) of both LINC00680 and CDKL5, suggesting that the modulation of LINC00680 on CDKL5 occurred via sequestering miR-320b. Conclusion: Overall, this study highlights the important role of LINC00680 in docetaxel resistance through the miR-320b/CDKL5 pathway and provides a novel therapeutic strategy for BC drug resistance." @default.
- W4282935823 created "2022-06-16" @default.
- W4282935823 creator A5007735109 @default.
- W4282935823 creator A5011544360 @default.
- W4282935823 creator A5011986375 @default.
- W4282935823 creator A5050895396 @default.
- W4282935823 date "2022-01-01" @default.
- W4282935823 modified "2023-09-27" @default.
- W4282935823 title "LINC00680 modulates docetaxel resistance in breast cancer via the miR-320b/CDKL5 axis" @default.
- W4282935823 cites W2012751367 @default.
- W4282935823 cites W2029962300 @default.
- W4282935823 cites W2042198997 @default.
- W4282935823 cites W2049001337 @default.
- W4282935823 cites W2049021349 @default.
- W4282935823 cites W2050806500 @default.
- W4282935823 cites W2069834221 @default.
- W4282935823 cites W2071244202 @default.
- W4282935823 cites W2083296039 @default.
- W4282935823 cites W2151275022 @default.
- W4282935823 cites W2296208951 @default.
- W4282935823 cites W2517126092 @default.
- W4282935823 cites W2618948029 @default.
- W4282935823 cites W2871099016 @default.
- W4282935823 cites W2898609637 @default.
- W4282935823 cites W2914679425 @default.
- W4282935823 cites W2968884715 @default.
- W4282935823 cites W2971126595 @default.
- W4282935823 cites W2987735094 @default.
- W4282935823 cites W2996078575 @default.
- W4282935823 cites W2999417355 @default.
- W4282935823 cites W3009337396 @default.
- W4282935823 cites W3010445736 @default.
- W4282935823 cites W3021568391 @default.
- W4282935823 cites W3049565972 @default.
- W4282935823 cites W3049963396 @default.
- W4282935823 cites W3092285225 @default.
- W4282935823 cites W3109861097 @default.
- W4282935823 cites W3158535107 @default.
- W4282935823 cites W3197096000 @default.
- W4282935823 doi "https://doi.org/10.1177/03946320221105608" @default.
- W4282935823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35667653" @default.
- W4282935823 hasPublicationYear "2022" @default.
- W4282935823 type Work @default.
- W4282935823 citedByCount "3" @default.
- W4282935823 countsByYear W42829358232022 @default.
- W4282935823 countsByYear W42829358232023 @default.
- W4282935823 crossrefType "journal-article" @default.
- W4282935823 hasAuthorship W4282935823A5007735109 @default.
- W4282935823 hasAuthorship W4282935823A5011544360 @default.
- W4282935823 hasAuthorship W4282935823A5011986375 @default.
- W4282935823 hasAuthorship W4282935823A5050895396 @default.
- W4282935823 hasBestOaLocation W42829358231 @default.
- W4282935823 hasConcept C104317684 @default.
- W4282935823 hasConcept C121608353 @default.
- W4282935823 hasConcept C126322002 @default.
- W4282935823 hasConcept C127561419 @default.
- W4282935823 hasConcept C173396325 @default.
- W4282935823 hasConcept C185592680 @default.
- W4282935823 hasConcept C190283241 @default.
- W4282935823 hasConcept C2781190966 @default.
- W4282935823 hasConcept C502942594 @default.
- W4282935823 hasConcept C55493867 @default.
- W4282935823 hasConcept C71924100 @default.
- W4282935823 hasConcept C98274493 @default.
- W4282935823 hasConceptScore W4282935823C104317684 @default.
- W4282935823 hasConceptScore W4282935823C121608353 @default.
- W4282935823 hasConceptScore W4282935823C126322002 @default.
- W4282935823 hasConceptScore W4282935823C127561419 @default.
- W4282935823 hasConceptScore W4282935823C173396325 @default.
- W4282935823 hasConceptScore W4282935823C185592680 @default.
- W4282935823 hasConceptScore W4282935823C190283241 @default.
- W4282935823 hasConceptScore W4282935823C2781190966 @default.
- W4282935823 hasConceptScore W4282935823C502942594 @default.
- W4282935823 hasConceptScore W4282935823C55493867 @default.
- W4282935823 hasConceptScore W4282935823C71924100 @default.
- W4282935823 hasConceptScore W4282935823C98274493 @default.
- W4282935823 hasFunder F4320336619 @default.
- W4282935823 hasLocation W42829358231 @default.
- W4282935823 hasLocation W42829358232 @default.
- W4282935823 hasLocation W42829358233 @default.
- W4282935823 hasLocation W42829358234 @default.
- W4282935823 hasOpenAccess W4282935823 @default.
- W4282935823 hasPrimaryLocation W42829358231 @default.
- W4282935823 hasRelatedWork W2024344351 @default.
- W4282935823 hasRelatedWork W2346343701 @default.
- W4282935823 hasRelatedWork W2494327966 @default.
- W4282935823 hasRelatedWork W2557443381 @default.
- W4282935823 hasRelatedWork W3204273758 @default.
- W4282935823 hasRelatedWork W3215845635 @default.
- W4282935823 hasRelatedWork W4220866825 @default.
- W4282935823 hasRelatedWork W4281477203 @default.
- W4282935823 hasRelatedWork W4281778281 @default.
- W4282935823 hasRelatedWork W4311271618 @default.
- W4282935823 hasVolume "36" @default.
- W4282935823 isParatext "false" @default.
- W4282935823 isRetracted "false" @default.
- W4282935823 workType "article" @default.